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Plasma steroid hormones, surgery for benign prostatic hyperplasia, and severe lower urinary tract symptoms.
Prostate Cancer Prostatic Dis 1999; 2(5/6):285-289PC

Abstract

Because benign prostatic hyperplasia (BPH) may be influenced by plasma steroid hormones, we examined their relation in the Health Professionals Follow-up Study. In 1993-1995, 18,000 cohort members provided blood. We selected as cases men who had had surgery for BPH (n=174) or who scored 20-35 points (n=126) on the American Urological Association index of severity of lower urinary tract symptoms. Cases were matched by age to men who scored</=3 points and without an enlarged prostate or elevated prostate-specific antigen. We estimated the odds ratio (OR) of BPH surgery and severe lower urinary tract symptoms for plasma testosterone (T), dihydrotestosterone (DHT), androstanediol glucuronide (AAG), estradiol (E2), and sex hormone binding globulin (SHBG) in multivariable conditional logistic regression models. Compared to the lowest tertiles, men in the middle (OR=1.42) and top (OR=1.78) tertiles of AAG were at increased risk for having either BPH surgery or severe lower urinary tract symptoms (P-trend=0.02). Men in the middle (OR=0.58) and top (OR=0.60) tertiles of E2 were at lower risk. T level was unrelated to surgery and symptoms. Our findings support opposing roles for DHT, reflected by its metabolite AAG, and E2 in the etiology of BPH.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, Mass., USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12497176

Citation

Platz, E A., et al. "Plasma Steroid Hormones, Surgery for Benign Prostatic Hyperplasia, and Severe Lower Urinary Tract Symptoms." Prostate Cancer and Prostatic Diseases, vol. 2, no. 5/6, 1999, pp. 285-289.
Platz EA, Kawachi I, Rimm EB, et al. Plasma steroid hormones, surgery for benign prostatic hyperplasia, and severe lower urinary tract symptoms. Prostate Cancer Prostatic Dis. 1999;2(5/6):285-289.
Platz, E. A., Kawachi, I., Rimm, E. B., Longcope, C., Stampfer, M. J., Willett, W. C., & Giovannucci, E. (1999). Plasma steroid hormones, surgery for benign prostatic hyperplasia, and severe lower urinary tract symptoms. Prostate Cancer and Prostatic Diseases, 2(5/6), pp. 285-289.
Platz EA, et al. Plasma Steroid Hormones, Surgery for Benign Prostatic Hyperplasia, and Severe Lower Urinary Tract Symptoms. Prostate Cancer Prostatic Dis. 1999;2(5/6):285-289. PubMed PMID: 12497176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma steroid hormones, surgery for benign prostatic hyperplasia, and severe lower urinary tract symptoms. AU - Platz,E A, AU - Kawachi,I, AU - Rimm,E B, AU - Longcope,C, AU - Stampfer,M J, AU - Willett,W C, AU - Giovannucci,E, PY - 1999/06/25/received PY - 1999/11/03/revised PY - 1999/11/12/accepted PY - 2002/12/24/pubmed PY - 2002/12/24/medline PY - 2002/12/24/entrez SP - 285 EP - 289 JF - Prostate cancer and prostatic diseases JO - Prostate Cancer Prostatic Dis. VL - 2 IS - 5/6 N2 - Because benign prostatic hyperplasia (BPH) may be influenced by plasma steroid hormones, we examined their relation in the Health Professionals Follow-up Study. In 1993-1995, 18,000 cohort members provided blood. We selected as cases men who had had surgery for BPH (n=174) or who scored 20-35 points (n=126) on the American Urological Association index of severity of lower urinary tract symptoms. Cases were matched by age to men who scored</=3 points and without an enlarged prostate or elevated prostate-specific antigen. We estimated the odds ratio (OR) of BPH surgery and severe lower urinary tract symptoms for plasma testosterone (T), dihydrotestosterone (DHT), androstanediol glucuronide (AAG), estradiol (E2), and sex hormone binding globulin (SHBG) in multivariable conditional logistic regression models. Compared to the lowest tertiles, men in the middle (OR=1.42) and top (OR=1.78) tertiles of AAG were at increased risk for having either BPH surgery or severe lower urinary tract symptoms (P-trend=0.02). Men in the middle (OR=0.58) and top (OR=0.60) tertiles of E2 were at lower risk. T level was unrelated to surgery and symptoms. Our findings support opposing roles for DHT, reflected by its metabolite AAG, and E2 in the etiology of BPH. SN - 1476-5608 UR - https://www.unboundmedicine.com/medline/citation/12497176/Plasma_steroid_hormones_surgery_for_benign_prostatic_hyperplasia_and_severe_lower_urinary_tract_symptoms_ L2 - http://dx.doi.org/10.1038/sj.pcan.4500380 DB - PRIME DP - Unbound Medicine ER -