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Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophrenia.
Am J Med Genet B Neuropsychiatr Genet. 2003 Jan 01; 116B(1):51-4.AJ

Abstract

The putative role of dopamine in the pathophysiology of tardive dyskinesia (TD) makes the genes coding for dopamine receptors the appropriate candidates for study. We investigate the association of the polymorphism of the Ser311Cys and Ser9Gly of the dopamine D2 (DRD2) and D3 receptor (DRD3) genes respectively with TD in Chinese patients with schizophrenia. In a case-control study, 117 Chinese patients with TD were compared to 200 patients without TD. Patients were diagnosed to have schizophrenia according to DSM-IV criteria. Dyskinesia was assessed by the Abnormal Involuntary Movement Scale (AIMS), whereas extrapyramidal side-effects (EPSE) were assessed by the Simpson-Angus Rating Scale. Genotype groups were comparable in age, gender, duration of illness, daily neuroleptic and benzodiazepine dose as well as the mean scores for EPSE. We failed to find an association between the polymorphism of the DRD2 gene with TD but found an increased risk of developing TD among those with D3 serine/serine genotype. Our results did not indicate that the D2 genotype has a role in the pathophysiology of TD in Chinese patients with schizophrenia. The association of TD with the serine/serine genotype of the DRD3 may be an epiphenomenon of patients with a subtype of schizophrenia who had more exposure to neuroleptics.

Authors+Show Affiliations

Woodbridge Hospital/Institute of Mental Health, Singapore. Siow_Ann_CHONG@imh.com.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12497614

Citation

Chong, Siow-Ann, et al. "Polymorphisms of Dopamine Receptors and Tardive Dyskinesia Among Chinese Patients With Schizophrenia." American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, vol. 116B, no. 1, 2003, pp. 51-4.
Chong SA, Tan EC, Tan CH, et al. Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003;116B(1):51-4.
Chong, S. A., Tan, E. C., Tan, C. H., Mythily, ., & Chan, Y. H. (2003). Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 116B(1), 51-4.
Chong SA, et al. Polymorphisms of Dopamine Receptors and Tardive Dyskinesia Among Chinese Patients With Schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003 Jan 1;116B(1):51-4. PubMed PMID: 12497614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophrenia. AU - Chong,Siow-Ann, AU - Tan,Ene-Choo, AU - Tan,Chay Hoon, AU - Mythily,, AU - Chan,Yiong Huak, PY - 2002/12/24/pubmed PY - 2003/5/6/medline PY - 2002/12/24/entrez SP - 51 EP - 4 JF - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics JO - Am. J. Med. Genet. B Neuropsychiatr. Genet. VL - 116B IS - 1 N2 - The putative role of dopamine in the pathophysiology of tardive dyskinesia (TD) makes the genes coding for dopamine receptors the appropriate candidates for study. We investigate the association of the polymorphism of the Ser311Cys and Ser9Gly of the dopamine D2 (DRD2) and D3 receptor (DRD3) genes respectively with TD in Chinese patients with schizophrenia. In a case-control study, 117 Chinese patients with TD were compared to 200 patients without TD. Patients were diagnosed to have schizophrenia according to DSM-IV criteria. Dyskinesia was assessed by the Abnormal Involuntary Movement Scale (AIMS), whereas extrapyramidal side-effects (EPSE) were assessed by the Simpson-Angus Rating Scale. Genotype groups were comparable in age, gender, duration of illness, daily neuroleptic and benzodiazepine dose as well as the mean scores for EPSE. We failed to find an association between the polymorphism of the DRD2 gene with TD but found an increased risk of developing TD among those with D3 serine/serine genotype. Our results did not indicate that the D2 genotype has a role in the pathophysiology of TD in Chinese patients with schizophrenia. The association of TD with the serine/serine genotype of the DRD3 may be an epiphenomenon of patients with a subtype of schizophrenia who had more exposure to neuroleptics. SN - 1552-4841 UR - https://www.unboundmedicine.com/medline/citation/12497614/Polymorphisms_of_dopamine_receptors_and_tardive_dyskinesia_among_Chinese_patients_with_schizophrenia_ L2 - https://doi.org/10.1002/ajmg.b.10004 DB - PRIME DP - Unbound Medicine ER -