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Cadherin-based cell adhesion in neuromuscular development.

Abstract

The organisation and differentiation of striated skeletal muscles and their innervation is a particularly complex process implicating cells of mesodermic (myoblasts and fibroblasts) and neuroectoderrmic origin (neurons and glial cells). Myogenic and motor neuron precursors, the two major cell types participating in the formation of the neuromuscular axis, migrate, segregate, reassociate and differentiate in a coordinated fashion. The subsequent organisation of muscle cells and the establishment of muscle innervation rely on a complex tissular and cellular architectural organisation, which cannot be understood without taking into account juxtacrine cell interactions, and especially cell adhesion. Cell adhesion receptors of the cadherin family are widely expressed and dynamically regulated in space and time throughout neuromuscular development. A single cell expresses in general more than one cadherin at its surface and it is the combination of these molecules and their level of expression that determine their action within a given cell population. We focused in this review on the expression and roles of classical cadherins in relation to muscle cell and motoneuron differentiation. We also review the latest results on the mode of action of cadherins allowing to propose cellular and molecular cues on the mechanisms by which these cell adhesion receptors control muscle and neuronal cell shape, migration and differentiation.

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  • Authors+Show Affiliations

    ,

    Signalisation et différenciation cellulaires dans les systèmes nerveux et musculaire, Inserm U440-Université Paris 6, Institut du Fer-à-Moulin, 17, rue du Fer-à-Moulin, 75005 Paris, France.

    , ,

    Source

    Biology of the cell 94:6 2002 Oct pg 315-26

    MeSH

    Animals
    Cadherins
    Cell Adhesion
    Gene Expression Regulation, Developmental
    Humans
    Muscle Development
    Muscle, Skeletal

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    12500939

    Citation

    Marthiens, Véronique, et al. "Cadherin-based Cell Adhesion in Neuromuscular Development." Biology of the Cell, vol. 94, no. 6, 2002, pp. 315-26.
    Marthiens V, Gavard J, Lambert M, et al. Cadherin-based cell adhesion in neuromuscular development. Biol Cell. 2002;94(6):315-26.
    Marthiens, V., Gavard, J., Lambert, M., & Mège, R. M. (2002). Cadherin-based cell adhesion in neuromuscular development. Biology of the Cell, 94(6), pp. 315-26.
    Marthiens V, et al. Cadherin-based Cell Adhesion in Neuromuscular Development. Biol Cell. 2002;94(6):315-26. PubMed PMID: 12500939.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cadherin-based cell adhesion in neuromuscular development. AU - Marthiens,Véronique, AU - Gavard,Julie, AU - Lambert,Mireille, AU - Mège,René Marc, PY - 2002/12/26/pubmed PY - 2003/12/19/medline PY - 2002/12/26/entrez SP - 315 EP - 26 JF - Biology of the cell JO - Biol. Cell VL - 94 IS - 6 N2 - The organisation and differentiation of striated skeletal muscles and their innervation is a particularly complex process implicating cells of mesodermic (myoblasts and fibroblasts) and neuroectoderrmic origin (neurons and glial cells). Myogenic and motor neuron precursors, the two major cell types participating in the formation of the neuromuscular axis, migrate, segregate, reassociate and differentiate in a coordinated fashion. The subsequent organisation of muscle cells and the establishment of muscle innervation rely on a complex tissular and cellular architectural organisation, which cannot be understood without taking into account juxtacrine cell interactions, and especially cell adhesion. Cell adhesion receptors of the cadherin family are widely expressed and dynamically regulated in space and time throughout neuromuscular development. A single cell expresses in general more than one cadherin at its surface and it is the combination of these molecules and their level of expression that determine their action within a given cell population. We focused in this review on the expression and roles of classical cadherins in relation to muscle cell and motoneuron differentiation. We also review the latest results on the mode of action of cadherins allowing to propose cellular and molecular cues on the mechanisms by which these cell adhesion receptors control muscle and neuronal cell shape, migration and differentiation. SN - 0248-4900 UR - https://www.unboundmedicine.com/medline/citation/12500939/Cadherin-based_cell_adhesion_in_neuromuscular_development L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0248-4900&date=2002&volume=94&issue=6&spage=315 DB - PRIME DP - Unbound Medicine ER -