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Glucagon, insulin and glucose levels in maternal and imbilical cord plasma with studies of placental transfer.

Abstract

Plasma immunoreactive glucagon, as well as insulin and glucose levels, was measured in 62 women and their infants following a term gestation vaginal delivery. Simultaneously obtained samples were drawn from the maternal antecubital vein (MV), umbilical vein (UV), and umbilical artery (UA). Forty-seven of these subjects were untreated (control) and 15 had received a maternal intravenous injection of 1 mg of glucagon within 40 minutes of delivery. It was shown that the umbilical cord glucagon levels were not different from the maternal levels in the control subjects (mean MU, 181.0; UU, 191.9; UA, 161.0 pg/ml). There was no correlation between the maternal and umbilical glucagon levels or the UV glucagon levels and the insulin or glucose concentrations. Neither the fetal sex, placental weight, or infant weight were correlated with the MV or UV glucagon concentration. Following the glucagon injection, the maternal plasma glucagon levels rose significantly, whereas the umbilical blood values did not change. These results suggest that glucagon does not significantly pass through the human term placenta.

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  • Authors

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    Source

    Obstetrics and gynecology 47:3 1976 Mar pg 291-4

    MeSH

    Blood Glucose
    Female
    Fetal Blood
    Glucagon
    Humans
    Insulin
    Maternal-Fetal Exchange
    Pancreas
    Placenta
    Pregnancy
    Umbilical Arteries
    Umbilical Veins

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    1250559

    Citation

    TY - JOUR T1 - Glucagon, insulin and glucose levels in maternal and imbilical cord plasma with studies of placental transfer. AU - Spellacy,W N, AU - Buhi,W C, PY - 1976/3/1/pubmed PY - 1976/3/1/medline PY - 1976/3/1/entrez SP - 291 EP - 4 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 47 IS - 3 N2 - Plasma immunoreactive glucagon, as well as insulin and glucose levels, was measured in 62 women and their infants following a term gestation vaginal delivery. Simultaneously obtained samples were drawn from the maternal antecubital vein (MV), umbilical vein (UV), and umbilical artery (UA). Forty-seven of these subjects were untreated (control) and 15 had received a maternal intravenous injection of 1 mg of glucagon within 40 minutes of delivery. It was shown that the umbilical cord glucagon levels were not different from the maternal levels in the control subjects (mean MU, 181.0; UU, 191.9; UA, 161.0 pg/ml). There was no correlation between the maternal and umbilical glucagon levels or the UV glucagon levels and the insulin or glucose concentrations. Neither the fetal sex, placental weight, or infant weight were correlated with the MV or UV glucagon concentration. Following the glucagon injection, the maternal plasma glucagon levels rose significantly, whereas the umbilical blood values did not change. These results suggest that glucagon does not significantly pass through the human term placenta. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/1250559/Glucagon_insulin_and_glucose_levels_in_maternal_and_imbilical_cord_plasma_with_studies_of_placental_transfer_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1250559.ui ER -