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Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects.

Abstract

Over the last few years considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of Cannabis. In Part I of this review we present a condensed survey of the chemistry of CBD; in Part II, to be published later, we shall discuss the anti-convulsive, anti-anxiety, anti-psychotic, anti-nausea and anti-rheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors and its mechanism of action is yet unknown. In Part II we shall also present evidence that it is conceivable that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its anti-oxidative effect.

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  • Authors+Show Affiliations

    ,

    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University of Jerusalem, Ein Kerem Campus, 91120, Jerusalem, Israel. mechou@cc.huji.ac.il

    Source

    Chemistry and physics of lipids 121:1-2 2002 Dec 31 pg 35-43

    MeSH

    Animals
    Cannabidiol
    Cannabis
    Humans

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12505688

    Citation

    Mechoulam, Raphael, and Lumír Hanus. "Cannabidiol: an Overview of some Chemical and Pharmacological Aspects. Part I: Chemical Aspects." Chemistry and Physics of Lipids, vol. 121, no. 1-2, 2002, pp. 35-43.
    Mechoulam R, Hanus L. Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects. Chem Phys Lipids. 2002;121(1-2):35-43.
    Mechoulam, R., & Hanus, L. (2002). Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects. Chemistry and Physics of Lipids, 121(1-2), pp. 35-43.
    Mechoulam R, Hanus L. Cannabidiol: an Overview of some Chemical and Pharmacological Aspects. Part I: Chemical Aspects. Chem Phys Lipids. 2002 Dec 31;121(1-2):35-43. PubMed PMID: 12505688.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects. AU - Mechoulam,Raphael, AU - Hanus,Lumír, PY - 2002/12/31/pubmed PY - 2003/8/23/medline PY - 2002/12/31/entrez SP - 35 EP - 43 JF - Chemistry and physics of lipids JO - Chem. Phys. Lipids VL - 121 IS - 1-2 N2 - Over the last few years considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of Cannabis. In Part I of this review we present a condensed survey of the chemistry of CBD; in Part II, to be published later, we shall discuss the anti-convulsive, anti-anxiety, anti-psychotic, anti-nausea and anti-rheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors and its mechanism of action is yet unknown. In Part II we shall also present evidence that it is conceivable that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its anti-oxidative effect. SN - 0009-3084 UR - https://www.unboundmedicine.com/medline/citation/12505688/Cannabidiol:_an_overview_of_some_chemical_and_pharmacological_aspects__Part_I:_chemical_aspects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009308402001445 DB - PRIME DP - Unbound Medicine ER -