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Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia.
Am J Psychiatry 2003; 160(1):156-64AJ

Abstract

OBJECTIVE

Smaller temporal lobe cortical gray matter volumes, including the left superior temporal gyrus, have been reported in magnetic resonance imaging (MRI) studies of patients with chronic schizophrenia and, more recently, in patients with first-episode schizophrenia. However, it remains unknown whether there are progressive decreases in temporal lobe cortical gray matter volumes in patients with first-episode schizophrenia and whether similarly progressive volume decreases are present in patients with affective psychosis.

METHOD

High-spatial-resolution MRI scans at initial hospitalization and 1.5 years later were obtained from 13 patients with first-episode schizophrenia, 15 patients with first-episode affective psychosis (mainly manic), and 14 healthy comparison subjects. MRI volumes were calculated for gray matter of superior temporal gyrus and for the amygdala-hippocampal complex.

RESULTS

Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left superior temporal gyrus compared with patients with first-episode affective psychosis or healthy comparison subjects. This progressive decrease was more pronounced in the posterior portion of the left superior temporal gyrus (mean=9.6%) than in the anterior portions (mean=8.4%). No group differences in the rate of change over time were present in other regions.

CONCLUSIONS

These findings demonstrate a progressive volume reduction of the left posterior superior temporal gyrus gray matter in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis.

Authors+Show Affiliations

Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12505815

Citation

Kasai, Kiyoto, et al. "Progressive Decrease of Left Superior Temporal Gyrus Gray Matter Volume in Patients With First-episode Schizophrenia." The American Journal of Psychiatry, vol. 160, no. 1, 2003, pp. 156-64.
Kasai K, Shenton ME, Salisbury DF, et al. Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. Am J Psychiatry. 2003;160(1):156-64.
Kasai, K., Shenton, M. E., Salisbury, D. F., Hirayasu, Y., Lee, C. U., Ciszewski, A. A., ... McCarley, R. W. (2003). Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. The American Journal of Psychiatry, 160(1), pp. 156-64.
Kasai K, et al. Progressive Decrease of Left Superior Temporal Gyrus Gray Matter Volume in Patients With First-episode Schizophrenia. Am J Psychiatry. 2003;160(1):156-64. PubMed PMID: 12505815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. AU - Kasai,Kiyoto, AU - Shenton,Martha E, AU - Salisbury,Dean F, AU - Hirayasu,Yoshio, AU - Lee,Chang-Uk, AU - Ciszewski,Aleksandra A, AU - Yurgelun-Todd,Deborah, AU - Kikinis,Ron, AU - Jolesz,Ferenc A, AU - McCarley,Robert W, PY - 2002/12/31/pubmed PY - 2003/1/31/medline PY - 2002/12/31/entrez SP - 156 EP - 64 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 160 IS - 1 N2 - OBJECTIVE: Smaller temporal lobe cortical gray matter volumes, including the left superior temporal gyrus, have been reported in magnetic resonance imaging (MRI) studies of patients with chronic schizophrenia and, more recently, in patients with first-episode schizophrenia. However, it remains unknown whether there are progressive decreases in temporal lobe cortical gray matter volumes in patients with first-episode schizophrenia and whether similarly progressive volume decreases are present in patients with affective psychosis. METHOD: High-spatial-resolution MRI scans at initial hospitalization and 1.5 years later were obtained from 13 patients with first-episode schizophrenia, 15 patients with first-episode affective psychosis (mainly manic), and 14 healthy comparison subjects. MRI volumes were calculated for gray matter of superior temporal gyrus and for the amygdala-hippocampal complex. RESULTS: Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left superior temporal gyrus compared with patients with first-episode affective psychosis or healthy comparison subjects. This progressive decrease was more pronounced in the posterior portion of the left superior temporal gyrus (mean=9.6%) than in the anterior portions (mean=8.4%). No group differences in the rate of change over time were present in other regions. CONCLUSIONS: These findings demonstrate a progressive volume reduction of the left posterior superior temporal gyrus gray matter in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/12505815/Progressive_decrease_of_left_superior_temporal_gyrus_gray_matter_volume_in_patients_with_first_episode_schizophrenia_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.160.1.156?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -