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[Relation of apolipoprotein E polymorphism to clinically diagnosed fatty liver disease].
Taehan Kan Hakhoe Chi. 2002 Dec; 8(4):355-62.TK

Abstract

BACKGROUND/AIMS

Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three common allelic forms, epsilon2, epsilon3, and epsilon4 at the APO E locus. The goal of this study was to examine the association between polymorphisms in the apolipoprotein E gene (APOE) and fatty liver disease.

METHODS

We examined the distribution of APOE alleles from 116 fatty liver patients and 50 controls in Korea.

RESULTS

The frequencies of APOE alleles in fatty liver patients were 6.5% in epsilon2, 85.7% in epsilon3 and 7.8% in epsilon4. The corresponding frequencies in control subjects were 4.0% in epsilon2, 91.0% in epsilon3 and 5.0% in epsilon4. There were no significant differences in the distribution of APOE genotypes between fatty liver patients and controls. APOE epsilon2 and epsilon4 allele frequencies in fatty liver patients were more than those in controls. However, there was no significant differences in APOE epsilon2 and epsilon4 allele frequencies.

CONCLUSIONS

These results suggest that APOE alleles seem not to be directly associated with the pathogenesis of fatty liver disease.

Authors+Show Affiliations

Lee DM
Department of Internal Medicine, Chonbuk National University College of Medicine, Chonju, Korea. daeghonkim@moak.chonbuk.ac.kr
Lee SO
No affiliation info available
Mun BS
No affiliation info available
Ahn HS
No affiliation info available
Park HY
No affiliation info available
Lee HS
No affiliation info available
Kim DG
No affiliation info available

MeSH

AdultAgedApolipoproteins EFatty LiverFemaleGene FrequencyHumansMaleMiddle AgedPolymorphism, Genetic

Pub Type(s)

English Abstract
Journal Article

Language

kor

PubMed ID

12506239

Citation

Lee, Dong-Min, et al. "[Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Fatty Liver Disease]." Taehan Kan Hakhoe Chi = the Korean Journal of Hepatology, vol. 8, no. 4, 2002, pp. 355-62.
Lee DM, Lee SO, Mun BS, et al. [Relation of apolipoprotein E polymorphism to clinically diagnosed fatty liver disease]. Taehan Kan Hakhoe Chi. 2002;8(4):355-62.
Lee, D. M., Lee, S. O., Mun, B. S., Ahn, H. S., Park, H. Y., Lee, H. S., & Kim, D. G. (2002). [Relation of apolipoprotein E polymorphism to clinically diagnosed fatty liver disease]. Taehan Kan Hakhoe Chi = the Korean Journal of Hepatology, 8(4), 355-62.
Lee DM, et al. [Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Fatty Liver Disease]. Taehan Kan Hakhoe Chi. 2002;8(4):355-62. PubMed PMID: 12506239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relation of apolipoprotein E polymorphism to clinically diagnosed fatty liver disease]. AU - Lee,Dong-Min, AU - Lee,Seung-Ok, AU - Mun,Byoung-Sik, AU - Ahn,Heok-Soo, AU - Park,Hye-Young, AU - Lee,Hye-Soo, AU - Kim,Dae-Ghon, PY - 2002/12/31/pubmed PY - 2004/4/16/medline PY - 2002/12/31/entrez SP - 355 EP - 62 JF - Taehan Kan Hakhoe chi = The Korean journal of hepatology JO - Taehan Kan Hakhoe Chi VL - 8 IS - 4 N2 - BACKGROUND/AIMS: Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three common allelic forms, epsilon2, epsilon3, and epsilon4 at the APO E locus. The goal of this study was to examine the association between polymorphisms in the apolipoprotein E gene (APOE) and fatty liver disease. METHODS: We examined the distribution of APOE alleles from 116 fatty liver patients and 50 controls in Korea. RESULTS: The frequencies of APOE alleles in fatty liver patients were 6.5% in epsilon2, 85.7% in epsilon3 and 7.8% in epsilon4. The corresponding frequencies in control subjects were 4.0% in epsilon2, 91.0% in epsilon3 and 5.0% in epsilon4. There were no significant differences in the distribution of APOE genotypes between fatty liver patients and controls. APOE epsilon2 and epsilon4 allele frequencies in fatty liver patients were more than those in controls. However, there was no significant differences in APOE epsilon2 and epsilon4 allele frequencies. CONCLUSIONS: These results suggest that APOE alleles seem not to be directly associated with the pathogenesis of fatty liver disease. SN - 1226-0479 UR - https://www.unboundmedicine.com/medline/citation/12506239/[Relation_of_apolipoprotein_E_polymorphism_to_clinically_diagnosed_fatty_liver_disease]_ DB - PRIME DP - Unbound Medicine ER -