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Antimutagenicity of mono-, di-, and tricaffeoylquinic acid derivatives isolated from sweetpotato (Ipomoea batatas L.) leaf.
Biosci Biotechnol Biochem. 2002 Nov; 66(11):2336-41.BB

Abstract

The caffeoylquinic acid derivatives, 3-mono-O-caffeoylquinic acid (chlorogenic acid, ChA), 3,4-di-O-caffeoylquinic acid (3,4-diCQA), 3,5-di-O-caffeoylquinic acid (3,5-diCQA), 4,5-di-O-caffeoylquinic acid (4,5-diCQA) and 3,4,5-tri-O-caffeoylquinic acid (3,4,5-triCQA), and caffeic acid (CA) were isolated from the sweetpotato (Ipomoea batatas L.) leaf. We examined the antimutagenicity of these caffeoylquinic acid compounds to promote new uses of the sweetpotato leaf. These caffeoylquinic acid derivatives effectively inhibited the reverse mutation induced by Trp-P-1 on Salmonella typhimurium TA 98. The antimutagenicity of these derivatives was 3,4,5-triCQA > 3,4-diCQA = 3,5-diCQA = 4,5-diCQA > ChA in this order. There was no difference in the antimutagenicity of all dicaffeoylquinic acid derivatives. A comparison of the activities and structures of these compounds suggested that the number of caffeoyl groups bound to quinic acid played a role in the antimutagenicity of the caffeoylquinic acid derivatives. The sweetpotato leaves contained distinctive polyphenolic components with a high content of mono-, di-, and tricaffeoylquinic acid derivatives and could be a source of physiological functions.

Authors+Show Affiliations

Department of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region, Miyakonojo, Miyazaki 885-0091, Japan. mak825@affrc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12506969

Citation

Yoshimoto, Makoto, et al. "Antimutagenicity of Mono-, Di-, and Tricaffeoylquinic Acid Derivatives Isolated From Sweetpotato (Ipomoea Batatas L.) Leaf." Bioscience, Biotechnology, and Biochemistry, vol. 66, no. 11, 2002, pp. 2336-41.
Yoshimoto M, Yahara S, Okuno S, et al. Antimutagenicity of mono-, di-, and tricaffeoylquinic acid derivatives isolated from sweetpotato (Ipomoea batatas L.) leaf. Biosci Biotechnol Biochem. 2002;66(11):2336-41.
Yoshimoto, M., Yahara, S., Okuno, S., Islam, M. S., Ishiguro, K., & Yamakawa, O. (2002). Antimutagenicity of mono-, di-, and tricaffeoylquinic acid derivatives isolated from sweetpotato (Ipomoea batatas L.) leaf. Bioscience, Biotechnology, and Biochemistry, 66(11), 2336-41.
Yoshimoto M, et al. Antimutagenicity of Mono-, Di-, and Tricaffeoylquinic Acid Derivatives Isolated From Sweetpotato (Ipomoea Batatas L.) Leaf. Biosci Biotechnol Biochem. 2002;66(11):2336-41. PubMed PMID: 12506969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimutagenicity of mono-, di-, and tricaffeoylquinic acid derivatives isolated from sweetpotato (Ipomoea batatas L.) leaf. AU - Yoshimoto,Makoto, AU - Yahara,Shoji, AU - Okuno,Shigenori, AU - Islam,Md Shahidul, AU - Ishiguro,Koji, AU - Yamakawa,Osamu, PY - 2003/1/1/pubmed PY - 2003/7/8/medline PY - 2003/1/1/entrez SP - 2336 EP - 41 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 66 IS - 11 N2 - The caffeoylquinic acid derivatives, 3-mono-O-caffeoylquinic acid (chlorogenic acid, ChA), 3,4-di-O-caffeoylquinic acid (3,4-diCQA), 3,5-di-O-caffeoylquinic acid (3,5-diCQA), 4,5-di-O-caffeoylquinic acid (4,5-diCQA) and 3,4,5-tri-O-caffeoylquinic acid (3,4,5-triCQA), and caffeic acid (CA) were isolated from the sweetpotato (Ipomoea batatas L.) leaf. We examined the antimutagenicity of these caffeoylquinic acid compounds to promote new uses of the sweetpotato leaf. These caffeoylquinic acid derivatives effectively inhibited the reverse mutation induced by Trp-P-1 on Salmonella typhimurium TA 98. The antimutagenicity of these derivatives was 3,4,5-triCQA > 3,4-diCQA = 3,5-diCQA = 4,5-diCQA > ChA in this order. There was no difference in the antimutagenicity of all dicaffeoylquinic acid derivatives. A comparison of the activities and structures of these compounds suggested that the number of caffeoyl groups bound to quinic acid played a role in the antimutagenicity of the caffeoylquinic acid derivatives. The sweetpotato leaves contained distinctive polyphenolic components with a high content of mono-, di-, and tricaffeoylquinic acid derivatives and could be a source of physiological functions. SN - 0916-8451 UR - https://www.unboundmedicine.com/medline/citation/12506969/Antimutagenicity_of_mono__di__and_tricaffeoylquinic_acid_derivatives_isolated_from_sweetpotato__Ipomoea_batatas_L___leaf_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/66.2336?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -