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Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study.
Nutrition 2003; 19(1):21-4N

Abstract

OBJECTIVE

We investigated the effect of long-term antioxidant supplementation (lutein and alpha-tocopherol) on serum levels and visual performance in patients with cataracts.

METHODS

Seventeen patients clinically diagnosed with age-related cataracts were randomized in a double-blind study involving dietary supplementation with lutein (15 mg; n = 5), alpha-tocopherol (100 mg; n = 6), or placebo (n = 6), three times a week for up to 2 y. Serum carotenoid and tocopherol concentrations were determined with quality-controlled high-performance liquid chromatography, and visual performance (visual acuity and glare sensitivity) and biochemical and hematologic indexes were monitored every 3 mo throughout the study. Changes in these parameters were assessed by General Linear Model (GLM) repeated measures analysis.

RESULTS

Serum concentrations of lutein and alpha-tocopherol increased with supplementation, although statistical significance was reached only in the lutein group. Visual performance (visual acuity and glare sensitivity) improved in the lutein group, whereas there was a trend toward the maintenance of and decrease in visual acuity with alpha-tocopherol and placebo supplementation, respectively. No significant side effects or changes in biochemical or hematologic profiles were observed in any of the subjects during the study.

CONCLUSIONS

Visual function in patients with age-related cataracts who received the lutein supplements improved, suggesting that a higher intake of lutein, through lutein-rich fruit and vegetables or supplements, may have beneficial effects on the visual performance of people with age-related cataracts.

Authors+Show Affiliations

Unidad de Vitaminas, Sección de Nutrición, Clínica Puerta de Hierro, Madrid, Spain. bolmedilla@hpth.insalud.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12507634

Citation

Olmedilla, B, et al. "Lutein, but Not Alpha-tocopherol, Supplementation Improves Visual Function in Patients With Age-related Cataracts: a 2-y Double-blind, Placebo-controlled Pilot Study." Nutrition (Burbank, Los Angeles County, Calif.), vol. 19, no. 1, 2003, pp. 21-4.
Olmedilla B, Granado F, Blanco I, et al. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. Nutrition. 2003;19(1):21-4.
Olmedilla, B., Granado, F., Blanco, I., & Vaquero, M. (2003). Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. Nutrition (Burbank, Los Angeles County, Calif.), 19(1), pp. 21-4.
Olmedilla B, et al. Lutein, but Not Alpha-tocopherol, Supplementation Improves Visual Function in Patients With Age-related Cataracts: a 2-y Double-blind, Placebo-controlled Pilot Study. Nutrition. 2003;19(1):21-4. PubMed PMID: 12507634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. AU - Olmedilla,B, AU - Granado,F, AU - Blanco,I, AU - Vaquero,M, PY - 2003/1/1/pubmed PY - 2003/5/28/medline PY - 2003/1/1/entrez SP - 21 EP - 4 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 19 IS - 1 N2 - OBJECTIVE: We investigated the effect of long-term antioxidant supplementation (lutein and alpha-tocopherol) on serum levels and visual performance in patients with cataracts. METHODS: Seventeen patients clinically diagnosed with age-related cataracts were randomized in a double-blind study involving dietary supplementation with lutein (15 mg; n = 5), alpha-tocopherol (100 mg; n = 6), or placebo (n = 6), three times a week for up to 2 y. Serum carotenoid and tocopherol concentrations were determined with quality-controlled high-performance liquid chromatography, and visual performance (visual acuity and glare sensitivity) and biochemical and hematologic indexes were monitored every 3 mo throughout the study. Changes in these parameters were assessed by General Linear Model (GLM) repeated measures analysis. RESULTS: Serum concentrations of lutein and alpha-tocopherol increased with supplementation, although statistical significance was reached only in the lutein group. Visual performance (visual acuity and glare sensitivity) improved in the lutein group, whereas there was a trend toward the maintenance of and decrease in visual acuity with alpha-tocopherol and placebo supplementation, respectively. No significant side effects or changes in biochemical or hematologic profiles were observed in any of the subjects during the study. CONCLUSIONS: Visual function in patients with age-related cataracts who received the lutein supplements improved, suggesting that a higher intake of lutein, through lutein-rich fruit and vegetables or supplements, may have beneficial effects on the visual performance of people with age-related cataracts. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/12507634/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899900702008614 DB - PRIME DP - Unbound Medicine ER -