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Refractive errors, intraocular pressure, and glaucoma in a white population.
Ophthalmology 2003; 110(1):211-7O

Abstract

OBJECTIVE

To examine the relation of refractive errors to glaucoma and intraocular pressure (IOP) in a defined white population.

DESIGN

Population-based cross-sectional and follow-up study.

PARTICIPANTS

Persons aged 43 to 86 years living in Beaver Dam, Wisconsin (n = 4926).

METHODS

All participants received a standardized assessment of refraction, IOP, and glaucoma at baseline (1988-1990), with IOP remeasured 5 years later (1993-1995). Refraction was defined at baseline as follows: myopia as spherical equivalent of -1.00 diopters (D) or less, emmetropia as -0.75 to +0.75 D, and hyperopia as +1.00 D or more.

MAIN OUTCOME MEASURES

Relation of baseline refraction to prevalent glaucoma (defined from IOP, optic disc, and visual field criteria) and incident ocular hypertension (defined as IOP more than 21 mmHg at the 5-year examination in eyes with IOP of 21 mmHg or less at baseline).

RESULTS

A myopic refraction was correlated with increasing IOP at baseline (P < 0.001). After controlling for age and gender, persons with myopia were 60% more likely to have prevalent glaucoma than those with emmetropia (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.1, 2.3). In contrast, controlling for age, gender, and baseline IOP, persons with hyperopia were 40% more likely to have incident ocular hypertension than those who were emmetropic at baseline (OR, 1.4; 95% CI, 1.0, 2.0). Myopia was not related to incident ocular hypertension.

CONCLUSIONS

In these population-based data, there was a cross-sectional association of myopia with higher IOP and prevalent glaucoma. Similar associations have been found in previous studies. Hyperopia may be associated with 5-year risk of ocular hypertension, a finding that needs further investigation.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12511368

Citation

Wong, Tien Yin, et al. "Refractive Errors, Intraocular Pressure, and Glaucoma in a White Population." Ophthalmology, vol. 110, no. 1, 2003, pp. 211-7.
Wong TY, Klein BE, Klein R, et al. Refractive errors, intraocular pressure, and glaucoma in a white population. Ophthalmology. 2003;110(1):211-7.
Wong, T. Y., Klein, B. E., Klein, R., Knudtson, M., & Lee, K. E. (2003). Refractive errors, intraocular pressure, and glaucoma in a white population. Ophthalmology, 110(1), pp. 211-7.
Wong TY, et al. Refractive Errors, Intraocular Pressure, and Glaucoma in a White Population. Ophthalmology. 2003;110(1):211-7. PubMed PMID: 12511368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Refractive errors, intraocular pressure, and glaucoma in a white population. AU - Wong,Tien Yin, AU - Klein,Barbara E K, AU - Klein,Ronald, AU - Knudtson,Michael, AU - Lee,Kristine E, PY - 2003/1/4/pubmed PY - 2003/1/17/medline PY - 2003/1/4/entrez SP - 211 EP - 7 JF - Ophthalmology JO - Ophthalmology VL - 110 IS - 1 N2 - OBJECTIVE: To examine the relation of refractive errors to glaucoma and intraocular pressure (IOP) in a defined white population. DESIGN: Population-based cross-sectional and follow-up study. PARTICIPANTS: Persons aged 43 to 86 years living in Beaver Dam, Wisconsin (n = 4926). METHODS: All participants received a standardized assessment of refraction, IOP, and glaucoma at baseline (1988-1990), with IOP remeasured 5 years later (1993-1995). Refraction was defined at baseline as follows: myopia as spherical equivalent of -1.00 diopters (D) or less, emmetropia as -0.75 to +0.75 D, and hyperopia as +1.00 D or more. MAIN OUTCOME MEASURES: Relation of baseline refraction to prevalent glaucoma (defined from IOP, optic disc, and visual field criteria) and incident ocular hypertension (defined as IOP more than 21 mmHg at the 5-year examination in eyes with IOP of 21 mmHg or less at baseline). RESULTS: A myopic refraction was correlated with increasing IOP at baseline (P < 0.001). After controlling for age and gender, persons with myopia were 60% more likely to have prevalent glaucoma than those with emmetropia (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.1, 2.3). In contrast, controlling for age, gender, and baseline IOP, persons with hyperopia were 40% more likely to have incident ocular hypertension than those who were emmetropic at baseline (OR, 1.4; 95% CI, 1.0, 2.0). Myopia was not related to incident ocular hypertension. CONCLUSIONS: In these population-based data, there was a cross-sectional association of myopia with higher IOP and prevalent glaucoma. Similar associations have been found in previous studies. Hyperopia may be associated with 5-year risk of ocular hypertension, a finding that needs further investigation. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/12511368/Refractive_errors_intraocular_pressure_and_glaucoma_in_a_white_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(02)01260-5 DB - PRIME DP - Unbound Medicine ER -