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Antileukemic principles isolated from euphorbiaceae plants.
Science. 1976 Feb 13; 191(4227):571-2.Sci

Abstract

Extracts of Euphorbia esula L. and Croton tiglium L., two members of the Euphorbiaceae which have been used widely in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice. Systematic fractionation of the extract of Euphorbia esula L. led to characterization of a major antileukemic component as the new diterpenoid diester, ingenol 3,20-dibenzoate. Similar fractionation of Croton oil led to characterization of phorbol 12-tiglate 13-decanoate as an active principle.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1251193

Citation

Kupchan, S M., et al. "Antileukemic Principles Isolated From Euphorbiaceae Plants." Science (New York, N.Y.), vol. 191, no. 4227, 1976, pp. 571-2.
Kupchan SM, Uchida I, Branfman AR, et al. Antileukemic principles isolated from euphorbiaceae plants. Science. 1976;191(4227):571-2.
Kupchan, S. M., Uchida, I., Branfman, A. R., Dailey, R. G., & Fei, B. Y. (1976). Antileukemic principles isolated from euphorbiaceae plants. Science (New York, N.Y.), 191(4227), 571-2.
Kupchan SM, et al. Antileukemic Principles Isolated From Euphorbiaceae Plants. Science. 1976 Feb 13;191(4227):571-2. PubMed PMID: 1251193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antileukemic principles isolated from euphorbiaceae plants. AU - Kupchan,S M, AU - Uchida,I, AU - Branfman,A R, AU - Dailey,R G,Jr AU - Fei,B Y, PY - 1976/2/23/pubmed PY - 2001/3/28/medline PY - 1976/2/23/entrez SP - 571 EP - 2 JF - Science (New York, N.Y.) JO - Science VL - 191 IS - 4227 N2 - Extracts of Euphorbia esula L. and Croton tiglium L., two members of the Euphorbiaceae which have been used widely in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice. Systematic fractionation of the extract of Euphorbia esula L. led to characterization of a major antileukemic component as the new diterpenoid diester, ingenol 3,20-dibenzoate. Similar fractionation of Croton oil led to characterization of phorbol 12-tiglate 13-decanoate as an active principle. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/1251193/Antileukemic_principles_isolated_from_euphorbiaceae_plants_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=1251193 DB - PRIME DP - Unbound Medicine ER -