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Immunohistochemical study of the pancreatic endocrine cells in the BALB/c mice: an unique distributional pattern of glucagon.
J Vet Sci. 2002 Sep; 3(3):167-73.JV

Abstract

The regional distribution and relative frequency of insulin-, glucagon-, somatostatin- and pancreatic polypeptide (PP)-producing endocrine cells in the pancreas of BALB/c mouse were investigated by immunohistochemical method. The pancreas of mice was divided into two portions; pancreatic islets and exocrine portions, and pancreatic islets were further subdivided into two regions (central and peripheral regions) and the relative frequency and regional distribution of immunoreactive cells against insulin, glucagon, somatostatin and PP antisera were monitored. In the pancreatic islet portions, insulin-immunoreactive cells were located in the central regions and they were randomly dispersed in the whole pancreatic islets in some case of the small islets. Quite different from those of other mammals, glucagon-immunoreactive cells were dispersed throughout central to peripheral regions in case of large islets and in the smaller ones, most of these cells were situated in the peripheral regions. Somatostatin-immunoreactive cells were detected in the peripheral regions with various frequencies. Although some cells were demonstrated in the central regions of pancreatic islets, most of PP-immunoreactive cells were located in the peripheral regions. In the exocrine portions, all four types of immunoreactive cells were demonstrated in the BALB/c mouse. Some peculiar distributional patterns of pancreatic endocrine cells were found in BALB/c mouse, especially in case of glucagon-immunoreactive cells.

Authors+Show Affiliations

Pharmacology & Toxicology Laboratory, Central Research Laboratories, Dong-Wha Pharm Ind Co, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12514327

Citation

Ku, Sae-Kwang, et al. "Immunohistochemical Study of the Pancreatic Endocrine Cells in the BALB/c Mice: an Unique Distributional Pattern of Glucagon." Journal of Veterinary Science, vol. 3, no. 3, 2002, pp. 167-73.
Ku SK, Lee HS, Lee JH. Immunohistochemical study of the pancreatic endocrine cells in the BALB/c mice: an unique distributional pattern of glucagon. J Vet Sci. 2002;3(3):167-73.
Ku, S. K., Lee, H. S., & Lee, J. H. (2002). Immunohistochemical study of the pancreatic endocrine cells in the BALB/c mice: an unique distributional pattern of glucagon. Journal of Veterinary Science, 3(3), 167-73.
Ku SK, Lee HS, Lee JH. Immunohistochemical Study of the Pancreatic Endocrine Cells in the BALB/c Mice: an Unique Distributional Pattern of Glucagon. J Vet Sci. 2002;3(3):167-73. PubMed PMID: 12514327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical study of the pancreatic endocrine cells in the BALB/c mice: an unique distributional pattern of glucagon. AU - Ku,Sae-Kwang, AU - Lee,Hyeung-Sik, AU - Lee,Jae-Hyun, PY - 2003/1/7/pubmed PY - 2003/3/6/medline PY - 2003/1/7/entrez SP - 167 EP - 73 JF - Journal of veterinary science JO - J Vet Sci VL - 3 IS - 3 N2 - The regional distribution and relative frequency of insulin-, glucagon-, somatostatin- and pancreatic polypeptide (PP)-producing endocrine cells in the pancreas of BALB/c mouse were investigated by immunohistochemical method. The pancreas of mice was divided into two portions; pancreatic islets and exocrine portions, and pancreatic islets were further subdivided into two regions (central and peripheral regions) and the relative frequency and regional distribution of immunoreactive cells against insulin, glucagon, somatostatin and PP antisera were monitored. In the pancreatic islet portions, insulin-immunoreactive cells were located in the central regions and they were randomly dispersed in the whole pancreatic islets in some case of the small islets. Quite different from those of other mammals, glucagon-immunoreactive cells were dispersed throughout central to peripheral regions in case of large islets and in the smaller ones, most of these cells were situated in the peripheral regions. Somatostatin-immunoreactive cells were detected in the peripheral regions with various frequencies. Although some cells were demonstrated in the central regions of pancreatic islets, most of PP-immunoreactive cells were located in the peripheral regions. In the exocrine portions, all four types of immunoreactive cells were demonstrated in the BALB/c mouse. Some peculiar distributional patterns of pancreatic endocrine cells were found in BALB/c mouse, especially in case of glucagon-immunoreactive cells. SN - 1229-845X UR - https://www.unboundmedicine.com/medline/citation/12514327/Immunohistochemical_study_of_the_pancreatic_endocrine_cells_in_the_BALB/c_mice:_an_unique_distributional_pattern_of_glucagon_ DB - PRIME DP - Unbound Medicine ER -