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Loci for CETP, LPL, LIPC, and APOC3 affect plasma lipoprotein size and sub-population distribution in Hispanic and non-Hispanic white subjects: the Columbia University BioMarkers Study.
Nutr Metab Cardiovasc Dis. 2002 Aug; 12(4):163-72.NM

Abstract

BACKGROUND AND AIM

The effect of genetic variation on plasma lipoproteins and their subfraction distribution was examined.

METHODS AND RESULTS

Forty Hispanic men and 223 women and 42 non-Hispanic white men and 53 women participated in the study. Genotypes for cholesteryl ester transfer protein (CETP TaqIB), hepatic lipase (LIPC -480 C > T), lipoprotein lipase (LPL S447X), and apolipoprotein CIII (APOC3--455T > C) were determined by polymerase chain reaction. Lipoprotein particle size distribution was determined by nuclear magnetic resonance. For all but APOC3, genotype effects were homogeneous in the ethnic/racial groups and men and women. Effects were seen primarily in the women. Compared to women carriers of the common CETP B1 allele, B2B2 women had significantly higher plasma levels of high-density lipoprotein cholesterol (HDL-C) (16.4.0%, p = 0.001), reflected in the level of larger HDL particles (21.9%, p = 0.001), and larger mean particle size of HDL (2.3%, p = 0.01) and low-density lipoproteins (LDL) (1.3%, p = 0.02). Compared to LPL 447S homozygous women carriers of the LPL 447X allele had significantly lower levels of very-low-density lipoprotein-triglyceride (VLDL-TG) (21.0%, p = 0.02). For APOC3, there was significant gender:genotype interaction with the genotype differences seen only in the men. Compared to men homozygous for the -455T allele, carriers of -455C had higher levels of VLDL-TG (71.4%, p = 0.0001), reflected in a larger mean VLDL particle size (13.7%, p = 0.009). LIPC genotype was not associated with significant effects on any of these traits.

CONCLUSION

These data confirm the role of genetic variants of CETP, LPL and APOC3 in determining the relationship between VLDL, LDL and HDL particles.

Authors+Show Affiliations

Division of Cardiovascular Genetics, Dept. of Medicine, UCL Medical School, Rayne Institute, University Street, London WC1E 6JJ, UK. rmhaseh@ucl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12514935

Citation

Humphries, S E., et al. "Loci for CETP, LPL, LIPC, and APOC3 Affect Plasma Lipoprotein Size and Sub-population Distribution in Hispanic and non-Hispanic White Subjects: the Columbia University BioMarkers Study." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 12, no. 4, 2002, pp. 163-72.
Humphries SE, Berglund L, Isasi CR, et al. Loci for CETP, LPL, LIPC, and APOC3 affect plasma lipoprotein size and sub-population distribution in Hispanic and non-Hispanic white subjects: the Columbia University BioMarkers Study. Nutr Metab Cardiovasc Dis. 2002;12(4):163-72.
Humphries, S. E., Berglund, L., Isasi, C. R., Otvos, J. D., Kaluski, D., Deckelbaum, R. J., Shea, S., & Talmud, P. J. (2002). Loci for CETP, LPL, LIPC, and APOC3 affect plasma lipoprotein size and sub-population distribution in Hispanic and non-Hispanic white subjects: the Columbia University BioMarkers Study. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 12(4), 163-72.
Humphries SE, et al. Loci for CETP, LPL, LIPC, and APOC3 Affect Plasma Lipoprotein Size and Sub-population Distribution in Hispanic and non-Hispanic White Subjects: the Columbia University BioMarkers Study. Nutr Metab Cardiovasc Dis. 2002;12(4):163-72. PubMed PMID: 12514935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Loci for CETP, LPL, LIPC, and APOC3 affect plasma lipoprotein size and sub-population distribution in Hispanic and non-Hispanic white subjects: the Columbia University BioMarkers Study. AU - Humphries,S E, AU - Berglund,L, AU - Isasi,C R, AU - Otvos,J D, AU - Kaluski,D, AU - Deckelbaum,R J, AU - Shea,S, AU - Talmud,P J, PY - 2003/1/8/pubmed PY - 2003/4/19/medline PY - 2003/1/8/entrez SP - 163 EP - 72 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 12 IS - 4 N2 - BACKGROUND AND AIM: The effect of genetic variation on plasma lipoproteins and their subfraction distribution was examined. METHODS AND RESULTS: Forty Hispanic men and 223 women and 42 non-Hispanic white men and 53 women participated in the study. Genotypes for cholesteryl ester transfer protein (CETP TaqIB), hepatic lipase (LIPC -480 C > T), lipoprotein lipase (LPL S447X), and apolipoprotein CIII (APOC3--455T > C) were determined by polymerase chain reaction. Lipoprotein particle size distribution was determined by nuclear magnetic resonance. For all but APOC3, genotype effects were homogeneous in the ethnic/racial groups and men and women. Effects were seen primarily in the women. Compared to women carriers of the common CETP B1 allele, B2B2 women had significantly higher plasma levels of high-density lipoprotein cholesterol (HDL-C) (16.4.0%, p = 0.001), reflected in the level of larger HDL particles (21.9%, p = 0.001), and larger mean particle size of HDL (2.3%, p = 0.01) and low-density lipoproteins (LDL) (1.3%, p = 0.02). Compared to LPL 447S homozygous women carriers of the LPL 447X allele had significantly lower levels of very-low-density lipoprotein-triglyceride (VLDL-TG) (21.0%, p = 0.02). For APOC3, there was significant gender:genotype interaction with the genotype differences seen only in the men. Compared to men homozygous for the -455T allele, carriers of -455C had higher levels of VLDL-TG (71.4%, p = 0.0001), reflected in a larger mean VLDL particle size (13.7%, p = 0.009). LIPC genotype was not associated with significant effects on any of these traits. CONCLUSION: These data confirm the role of genetic variants of CETP, LPL and APOC3 in determining the relationship between VLDL, LDL and HDL particles. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/12514935/Loci_for_CETP_LPL_LIPC_and_APOC3_affect_plasma_lipoprotein_size_and_sub_population_distribution_in_Hispanic_and_non_Hispanic_white_subjects:_the_Columbia_University_BioMarkers_Study_ L2 - https://medlineplus.gov/latinoandhispanicamericanhealth.html DB - PRIME DP - Unbound Medicine ER -