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Familial clustering of selective IgA deficiency.

Abstract

Serum IgA levels of 35 healthy IgA-deficient index cases, of their 180 first-degree relatives, and of 31 other family members were studied. IgA deficiency was detected in 7.2% of the first-degree relatives, which is significantly more than the 0.25% frequency of IgA deficiency in healthy Finnish blood donors. Subnormal serum IgA levels were found in additional 13 (7.2%) first-degree relatives. The familial clustering of IgA deficiency seemed to be controlled by multigenic factors. IgA-deficient persons and their family members were tested for antinuclear and antithyroid antibodies, for rheumatoid factor (by latex test) and for other anti-IgG antibodies (by Ripley test). Antibodies against bovine milk were also studied. The relatives of IgA-deficient persons did not have more of these antibodies than the controls. It is suggested that various serological abnormalities are a consequence of the IgA deficiency rather than of genetic defects per se.

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    Source

    Vox sanguinis 30:3 1976 pg 181-90

    MeSH

    Autoantibodies
    Dysgammaglobulinemia
    Female
    Finland
    Genetics, Population
    Humans
    Immunoglobulin A
    Immunoglobulin G
    Immunoglobulin M
    Immunologic Deficiency Syndromes
    Male
    Pedigree

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    1251582

    Citation

    Koistinen, J. "Familial Clustering of Selective IgA Deficiency." Vox Sanguinis, vol. 30, no. 3, 1976, pp. 181-90.
    Koistinen J. Familial clustering of selective IgA deficiency. Vox Sang. 1976;30(3):181-90.
    Koistinen, J. (1976). Familial clustering of selective IgA deficiency. Vox Sanguinis, 30(3), pp. 181-90.
    Koistinen J. Familial Clustering of Selective IgA Deficiency. Vox Sang. 1976;30(3):181-90. PubMed PMID: 1251582.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Familial clustering of selective IgA deficiency. A1 - Koistinen,J, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 181 EP - 90 JF - Vox sanguinis JO - Vox Sang. VL - 30 IS - 3 N2 - Serum IgA levels of 35 healthy IgA-deficient index cases, of their 180 first-degree relatives, and of 31 other family members were studied. IgA deficiency was detected in 7.2% of the first-degree relatives, which is significantly more than the 0.25% frequency of IgA deficiency in healthy Finnish blood donors. Subnormal serum IgA levels were found in additional 13 (7.2%) first-degree relatives. The familial clustering of IgA deficiency seemed to be controlled by multigenic factors. IgA-deficient persons and their family members were tested for antinuclear and antithyroid antibodies, for rheumatoid factor (by latex test) and for other anti-IgG antibodies (by Ripley test). Antibodies against bovine milk were also studied. The relatives of IgA-deficient persons did not have more of these antibodies than the controls. It is suggested that various serological abnormalities are a consequence of the IgA deficiency rather than of genetic defects per se. SN - 0042-9007 UR - https://www.unboundmedicine.com/medline/citation/1251582/Familial_clustering_of_selective_IgA_deficiency_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0042-9007&date=1976&volume=30&issue=3&spage=181 DB - PRIME DP - Unbound Medicine ER -