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[Fungal keratitis at the Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts: retrospective study of 19 cases].
J Fr Ophtalmol 2002; 25(9):890-6JF

Abstract

PURPOSE

To report the spectrum of fungal keratitis at the Centre Hospitalier National d'Ophtalmologie XV-XX, Paris.

METHODS

We reviewed 19 cases of fungal keratitis from January 1993 to January 2001. We evaluated the different risk factors, fungal identification, topical and systemic antifungal therapy, surgical treatment and outcome.

RESULTS

Nineteen patients were included, 7 women and 12 men, with visual acuity ranging from 9/10 to no perception of light. The mean age was 56.2 years. Patients were hospitalized for an average stay of 16.3 days and all received a diagnostic and therapeutic scraping and 16 received a local antifungal treatment. The most common risk factors were topical steroid treatment (42.1%), corneal graft (31.6%), trauma or foreign body (31.6%). The mean delay between the first signs and fungal keratitis diagnosis was 14 days. Yeast as Candida parapsilosis and albicans were the most frequently isolated fungi (58%), followed by Aspergillus sp. (21%) and Fusarium sp. (21%). The most commonly used topical treatment was amphotericin B, and itraconazole was used as systemic treatment. Five patients had evisceration, 6 had penetrating keratoplasty and 5 retained leukoma.

CONCLUSION

Candida was the most frequently isolated fungi and topical steroid treatment the main risk factor. The prognosis is relatively poor (26% of lost vision) because of a delay in diagnosis and other previous ocular pathology or surgery.

Authors+Show Affiliations

Service 5, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, 28 rue de Charenton, 75012, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

fre

PubMed ID

12515932

Citation

Rondeau, N, et al. "[Fungal Keratitis at the Centre Hospitalier National d'Ophtalmologie Des Quinze-Vingts: Retrospective Study of 19 Cases]." Journal Francais D'ophtalmologie, vol. 25, no. 9, 2002, pp. 890-6.
Rondeau N, Bourcier T, Chaumeil C, et al. [Fungal keratitis at the Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts: retrospective study of 19 cases]. J Fr Ophtalmol. 2002;25(9):890-6.
Rondeau, N., Bourcier, T., Chaumeil, C., Borderie, V., Touzeau, O., Scat, Y., ... Laroche, L. (2002). [Fungal keratitis at the Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts: retrospective study of 19 cases]. Journal Francais D'ophtalmologie, 25(9), pp. 890-6.
Rondeau N, et al. [Fungal Keratitis at the Centre Hospitalier National d'Ophtalmologie Des Quinze-Vingts: Retrospective Study of 19 Cases]. J Fr Ophtalmol. 2002;25(9):890-6. PubMed PMID: 12515932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fungal keratitis at the Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts: retrospective study of 19 cases]. AU - Rondeau,N, AU - Bourcier,T, AU - Chaumeil,C, AU - Borderie,V, AU - Touzeau,O, AU - Scat,Y, AU - Thomas,F, AU - Baudouin,C, AU - Nordmann,J-P, AU - Laroche,L, PY - 2003/1/8/pubmed PY - 2003/2/13/medline PY - 2003/1/8/entrez SP - 890 EP - 6 JF - Journal francais d'ophtalmologie JO - J Fr Ophtalmol VL - 25 IS - 9 N2 - PURPOSE: To report the spectrum of fungal keratitis at the Centre Hospitalier National d'Ophtalmologie XV-XX, Paris. METHODS: We reviewed 19 cases of fungal keratitis from January 1993 to January 2001. We evaluated the different risk factors, fungal identification, topical and systemic antifungal therapy, surgical treatment and outcome. RESULTS: Nineteen patients were included, 7 women and 12 men, with visual acuity ranging from 9/10 to no perception of light. The mean age was 56.2 years. Patients were hospitalized for an average stay of 16.3 days and all received a diagnostic and therapeutic scraping and 16 received a local antifungal treatment. The most common risk factors were topical steroid treatment (42.1%), corneal graft (31.6%), trauma or foreign body (31.6%). The mean delay between the first signs and fungal keratitis diagnosis was 14 days. Yeast as Candida parapsilosis and albicans were the most frequently isolated fungi (58%), followed by Aspergillus sp. (21%) and Fusarium sp. (21%). The most commonly used topical treatment was amphotericin B, and itraconazole was used as systemic treatment. Five patients had evisceration, 6 had penetrating keratoplasty and 5 retained leukoma. CONCLUSION: Candida was the most frequently isolated fungi and topical steroid treatment the main risk factor. The prognosis is relatively poor (26% of lost vision) because of a delay in diagnosis and other previous ocular pathology or surgery. SN - 0181-5512 UR - https://www.unboundmedicine.com/medline/citation/12515932/[Fungal_keratitis_at_the_Centre_Hospitalier_National_d'Ophtalmologie_des_Quinze_Vingts:_retrospective_study_of_19_cases]_ L2 - https://ClinicalTrials.gov/search/term=12515932 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -