Tags

Type your tag names separated by a space and hit enter

Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus.
Int J Cancer. 2003 Mar 01; 103(6):815-21.IJ

Abstract

Infection with Helicobacter pylori (H. pylori), especially CagA+ strains, has been associated with an increased risk of noncardia gastric adenocarcinoma. The relationship with junctional cancer (adenocarcinomas of the esophagus and gastric cardia combined) has not been adequately investigated, although some studies have reported a reduced risk associated with H. pylori and CagA seroseropositivity. We investigated this question in a subset of cases and controls from a recently completed, large population-based case-control study of gastric and esophageal adenocarcinomas in Los Angeles County. Using established antigen-specific ELISAs, serum IgG antibodies to H. pylori whole-cell antigens (Helico-G) and CagA were measured in population controls (n = 356) and patients with incident esophageal adenocarcinoma (n = 80), gastric cardia cancer (n = 87) or distal gastric cancers (noncardia gastric adenocarcinoma) (n = 127). After controlling for demographic characteristics (age, gender, race, birthplace, education), smoking and body mass index, seropositivity for H. pylori was associated with a statistically significant increased risk of distal gastric cancer (adjusted odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.03, 3.32) but the risk of junctional cancer was not increased (adjusted OR = 1.26, 95% CI = 0.82, 1.94). The risk of junctional cancer was not changed when CagA and H. pylori were both considered, but the risk of distal gastric cancer was further increased. Subjects who were seropositive for both CagA and H. pylori compared to those who were seronegative for H. pylori showed a risk of 2.20 (95% CI = 1.13, 4.26) for distal gastric cancer and 0.86 (95% CI = 0.47, 1.59) for junctional cancer. Although tests for interaction between smoking and H. pylori were not statistically significant for junctional or distal gastric cancers, risk for both tumor types tended to be higher among current smokers who were also H. pylori seropositive. In conclusion, we find no evidence that infection with CagA+ strains of H. pylori reduces risk of esophageal and gastric cardia adenocarcinoma in this population. Our findings confirm the positive association between risk of distal gastric cancer and infection with H. pylori infection, especially CagA+ strains.

Authors+Show Affiliations

Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089-9175, USA. annawu@hsc.usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12516104

Citation

Wu, Anna H., et al. "Role of Helicobacter Pylori CagA+ Strains and Risk of Adenocarcinoma of the Stomach and Esophagus." International Journal of Cancer, vol. 103, no. 6, 2003, pp. 815-21.
Wu AH, Crabtree JE, Bernstein L, et al. Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus. Int J Cancer. 2003;103(6):815-21.
Wu, A. H., Crabtree, J. E., Bernstein, L., Hawtin, P., Cockburn, M., Tseng, C. C., & Forman, D. (2003). Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus. International Journal of Cancer, 103(6), 815-21.
Wu AH, et al. Role of Helicobacter Pylori CagA+ Strains and Risk of Adenocarcinoma of the Stomach and Esophagus. Int J Cancer. 2003 Mar 1;103(6):815-21. PubMed PMID: 12516104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus. AU - Wu,Anna H, AU - Crabtree,Jean E, AU - Bernstein,Leslie, AU - Hawtin,Peter, AU - Cockburn,Myles, AU - Tseng,Chiu-chen, AU - Forman,David, PY - 2003/1/8/pubmed PY - 2003/2/13/medline PY - 2003/1/8/entrez SP - 815 EP - 21 JF - International journal of cancer JO - Int J Cancer VL - 103 IS - 6 N2 - Infection with Helicobacter pylori (H. pylori), especially CagA+ strains, has been associated with an increased risk of noncardia gastric adenocarcinoma. The relationship with junctional cancer (adenocarcinomas of the esophagus and gastric cardia combined) has not been adequately investigated, although some studies have reported a reduced risk associated with H. pylori and CagA seroseropositivity. We investigated this question in a subset of cases and controls from a recently completed, large population-based case-control study of gastric and esophageal adenocarcinomas in Los Angeles County. Using established antigen-specific ELISAs, serum IgG antibodies to H. pylori whole-cell antigens (Helico-G) and CagA were measured in population controls (n = 356) and patients with incident esophageal adenocarcinoma (n = 80), gastric cardia cancer (n = 87) or distal gastric cancers (noncardia gastric adenocarcinoma) (n = 127). After controlling for demographic characteristics (age, gender, race, birthplace, education), smoking and body mass index, seropositivity for H. pylori was associated with a statistically significant increased risk of distal gastric cancer (adjusted odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.03, 3.32) but the risk of junctional cancer was not increased (adjusted OR = 1.26, 95% CI = 0.82, 1.94). The risk of junctional cancer was not changed when CagA and H. pylori were both considered, but the risk of distal gastric cancer was further increased. Subjects who were seropositive for both CagA and H. pylori compared to those who were seronegative for H. pylori showed a risk of 2.20 (95% CI = 1.13, 4.26) for distal gastric cancer and 0.86 (95% CI = 0.47, 1.59) for junctional cancer. Although tests for interaction between smoking and H. pylori were not statistically significant for junctional or distal gastric cancers, risk for both tumor types tended to be higher among current smokers who were also H. pylori seropositive. In conclusion, we find no evidence that infection with CagA+ strains of H. pylori reduces risk of esophageal and gastric cardia adenocarcinoma in this population. Our findings confirm the positive association between risk of distal gastric cancer and infection with H. pylori infection, especially CagA+ strains. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/12516104/Role_of_Helicobacter_pylori_CagA+_strains_and_risk_of_adenocarcinoma_of_the_stomach_and_esophagus_ L2 - https://doi.org/10.1002/ijc.10887 DB - PRIME DP - Unbound Medicine ER -