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[Thyroid peroxidase antibodies and thyroid diseases in children and adolescents with newly diagnosed type I diabetes].
Przegl Lek. 2002; 59(7):509-13.PL

Abstract

The objective of the authors was to evaluate the prevalence of TPO Ab and thyroid diseases in children with newly diagnosed type 1 diabetes. The examination included 153 patients (85/55.6% girls) from southeast Poland aged 11 months to do 17.4 years (mean age 9.5 +/- 3.9 years). Apart from clinical assessment, all children had determinations made of serum TPO Ab, FT4 and TSH, while thyroid ultra sound was performed in each patients with abnormal thyroid morphology and/or positive TPO Ab titter. Positive TPO Ab was detected in 45 patients (29.4%). In this group 26 had isolated serum TPO Ab elevation, 18 had Hashimoto's disease, 1 Graves's disease. Another 12 children (7.8%) were demonstrated to have euthyroid goiter. Thyroid abnormalities were thus seen in 37.2% children with newly diagnosed type 1 diabetes. No association was demonstrated between the prevalence of thyroid abnormalities and sex. Children with subclinical stage of autoimmune thyreoiditis were significantly younger in comparison to patients with Hashimoto's disease (8.9 +/- 4.2 vs. 12.0 +/- 3.1 years) and had significantly lower serum TPO Ab and TSH levels (314.2 +/- 232.4 vs. 2076.8 +/- 1300.8 U/ml, 1.7 +/- 0.82 vs. 4.1 +/- 2.9 ulU/ml, respectively). Thyroid dysfunction was detected in 7 (4.6%) children with newly diagnosed type 1 diabetes. In comparison to the entire group with positive serum TPO Ab titer in these 7 children the percentage of patients with thyroid dysfunction was significantly higher (15.5%). Six patients were hypothyroid and 1 had hyperthyreosis. The present results justify the need for comprehensive screening for thyroid disorders in all children with newly diagnosed type 1 diabetes.

Authors+Show Affiliations

Klinika Endokrynologii Dzieci i Młodziezy Katedry Pediatrii, Polsko-Amerykańskiego Instytutu Pediatrii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie Były Kierownik Kliniki Endokrynologii Dzieci i Młodziezy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

12516239

Citation

Kalicka-Kasperczyk, Anna, et al. "[Thyroid Peroxidase Antibodies and Thyroid Diseases in Children and Adolescents With Newly Diagnosed Type I Diabetes]." Przeglad Lekarski, vol. 59, no. 7, 2002, pp. 509-13.
Kalicka-Kasperczyk A, Dziatkowiak H, Bartnik-Mikuta A, et al. [Thyroid peroxidase antibodies and thyroid diseases in children and adolescents with newly diagnosed type I diabetes]. Prz Lek. 2002;59(7):509-13.
Kalicka-Kasperczyk, A., Dziatkowiak, H., Bartnik-Mikuta, A., Pituch-Noworolska, A., Kasperczyk, K., Nazim, J., Sztefko, K., & Starzyk, J. (2002). [Thyroid peroxidase antibodies and thyroid diseases in children and adolescents with newly diagnosed type I diabetes]. Przeglad Lekarski, 59(7), 509-13.
Kalicka-Kasperczyk A, et al. [Thyroid Peroxidase Antibodies and Thyroid Diseases in Children and Adolescents With Newly Diagnosed Type I Diabetes]. Prz Lek. 2002;59(7):509-13. PubMed PMID: 12516239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Thyroid peroxidase antibodies and thyroid diseases in children and adolescents with newly diagnosed type I diabetes]. AU - Kalicka-Kasperczyk,Anna, AU - Dziatkowiak,Hanna, AU - Bartnik-Mikuta,Anna, AU - Pituch-Noworolska,Anna, AU - Kasperczyk,Krzysztof, AU - Nazim,Joanna, AU - Sztefko,Krystyna, AU - Starzyk,Jerzy, PY - 2003/1/9/pubmed PY - 2003/2/1/medline PY - 2003/1/9/entrez SP - 509 EP - 13 JF - Przeglad lekarski JO - Prz. Lek. VL - 59 IS - 7 N2 - The objective of the authors was to evaluate the prevalence of TPO Ab and thyroid diseases in children with newly diagnosed type 1 diabetes. The examination included 153 patients (85/55.6% girls) from southeast Poland aged 11 months to do 17.4 years (mean age 9.5 +/- 3.9 years). Apart from clinical assessment, all children had determinations made of serum TPO Ab, FT4 and TSH, while thyroid ultra sound was performed in each patients with abnormal thyroid morphology and/or positive TPO Ab titter. Positive TPO Ab was detected in 45 patients (29.4%). In this group 26 had isolated serum TPO Ab elevation, 18 had Hashimoto's disease, 1 Graves's disease. Another 12 children (7.8%) were demonstrated to have euthyroid goiter. Thyroid abnormalities were thus seen in 37.2% children with newly diagnosed type 1 diabetes. No association was demonstrated between the prevalence of thyroid abnormalities and sex. Children with subclinical stage of autoimmune thyreoiditis were significantly younger in comparison to patients with Hashimoto's disease (8.9 +/- 4.2 vs. 12.0 +/- 3.1 years) and had significantly lower serum TPO Ab and TSH levels (314.2 +/- 232.4 vs. 2076.8 +/- 1300.8 U/ml, 1.7 +/- 0.82 vs. 4.1 +/- 2.9 ulU/ml, respectively). Thyroid dysfunction was detected in 7 (4.6%) children with newly diagnosed type 1 diabetes. In comparison to the entire group with positive serum TPO Ab titer in these 7 children the percentage of patients with thyroid dysfunction was significantly higher (15.5%). Six patients were hypothyroid and 1 had hyperthyreosis. The present results justify the need for comprehensive screening for thyroid disorders in all children with newly diagnosed type 1 diabetes. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/12516239/[Thyroid_peroxidase_antibodies_and_thyroid_diseases_in_children_and_adolescents_with_newly_diagnosed_type_I_diabetes]_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -