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A direct catalytic asymmetric mannich-type reaction to syn-amino alcohols.
J Am Chem Soc. 2003 Jan 15; 125(2):338-9.JA

Abstract

The Mannich reaction is one of the most widely utilized chemical transformations for the construction of nitrogen-containing compounds. With the increasing occurrence of nitrogen in drugs and natural products, highly asymmetric variants of the Mannich reaction are desirable. In this communication, we report the application of our dinuclear zinc catalyst to a highly asymmetric Mannich-type reaction to generate syn 1,2-amino alcohols.

Authors+Show Affiliations

Department of Chemistry, Stanford University, California 94305-5080, USA. bmtrost@stanford.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12517138

Citation

Trost, Barry M., and Lamont R. Terrell. "A Direct Catalytic Asymmetric Mannich-type Reaction to Syn-amino Alcohols." Journal of the American Chemical Society, vol. 125, no. 2, 2003, pp. 338-9.
Trost BM, Terrell LR. A direct catalytic asymmetric mannich-type reaction to syn-amino alcohols. J Am Chem Soc. 2003;125(2):338-9.
Trost, B. M., & Terrell, L. R. (2003). A direct catalytic asymmetric mannich-type reaction to syn-amino alcohols. Journal of the American Chemical Society, 125(2), 338-9.
Trost BM, Terrell LR. A Direct Catalytic Asymmetric Mannich-type Reaction to Syn-amino Alcohols. J Am Chem Soc. 2003 Jan 15;125(2):338-9. PubMed PMID: 12517138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A direct catalytic asymmetric mannich-type reaction to syn-amino alcohols. AU - Trost,Barry M, AU - Terrell,Lamont R, PY - 2003/1/9/pubmed PY - 2003/3/15/medline PY - 2003/1/9/entrez SP - 338 EP - 9 JF - Journal of the American Chemical Society JO - J Am Chem Soc VL - 125 IS - 2 N2 - The Mannich reaction is one of the most widely utilized chemical transformations for the construction of nitrogen-containing compounds. With the increasing occurrence of nitrogen in drugs and natural products, highly asymmetric variants of the Mannich reaction are desirable. In this communication, we report the application of our dinuclear zinc catalyst to a highly asymmetric Mannich-type reaction to generate syn 1,2-amino alcohols. SN - 0002-7863 UR - https://www.unboundmedicine.com/medline/citation/12517138/A_direct_catalytic_asymmetric_mannich_type_reaction_to_syn_amino_alcohols_ L2 - https://doi.org/10.1021/ja028782e DB - PRIME DP - Unbound Medicine ER -
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