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[Recommendations for the management of women with an increased genetic risk of gynaecological cancer].
Ned Tijdschr Geneeskd. 2002 Dec 14; 146(50):2414-8.NT

Abstract

About 5% of all ovarian-cancer cases are caused by a genetic predisposition, in particular as a component of the autosomal dominant hereditary breast-ovarian-cancer syndrome. This syndrome is usually due to germline mutations in the BRCA1- or BRCA2-gene. Ovarian and endometrial cancer also occur in families with hereditary non-polyposis colorectal cancer (HNPCC). This syndrome is caused by germline mutations in DNA mismatch-repair genes. Women at high risk of gynaecological cancer based upon familial clustering of disease or a demonstrated pathogenic germ-line mutation are candidates for surveillance: annual gynaecological examinations, including vaginal echoscopy and serum carcinoma antigen CA125 testing. Prophylactic surgery in the form of adnexectomy leads to a marked, but not complete, reduction of ovarian-cancer risk in high-risk cases. There is insufficient evidence to advise against the use of oral contraceptives or hormonal substitution after adnexectomy for healthy women with a genetic predisposition to breast cancer. Recommendations for surveillance and prevention should only be given after genetic-risk counselling, based on a detailed family study and DNA-based diagnosis.

Authors+Show Affiliations

Afd. Verloskunde en Gynaecologie, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam. r.verheijen@vumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

12518519

Citation

Verheijen, R H M., et al. "[Recommendations for the Management of Women With an Increased Genetic Risk of Gynaecological Cancer]." Nederlands Tijdschrift Voor Geneeskunde, vol. 146, no. 50, 2002, pp. 2414-8.
Verheijen RH, Boonstra H, Menko FH, et al. [Recommendations for the management of women with an increased genetic risk of gynaecological cancer]. Ned Tijdschr Geneeskd. 2002;146(50):2414-8.
Verheijen, R. H., Boonstra, H., Menko, F. H., de Graaff, J., Vasen, H. F., & Kenter, G. G. (2002). [Recommendations for the management of women with an increased genetic risk of gynaecological cancer]. Nederlands Tijdschrift Voor Geneeskunde, 146(50), 2414-8.
Verheijen RH, et al. [Recommendations for the Management of Women With an Increased Genetic Risk of Gynaecological Cancer]. Ned Tijdschr Geneeskd. 2002 Dec 14;146(50):2414-8. PubMed PMID: 12518519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Recommendations for the management of women with an increased genetic risk of gynaecological cancer]. AU - Verheijen,R H M, AU - Boonstra,H, AU - Menko,F H, AU - de Graaff,J, AU - Vasen,H F A, AU - Kenter,G G, PY - 2003/1/10/pubmed PY - 2003/4/4/medline PY - 2003/1/10/entrez SP - 2414 EP - 8 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 146 IS - 50 N2 - About 5% of all ovarian-cancer cases are caused by a genetic predisposition, in particular as a component of the autosomal dominant hereditary breast-ovarian-cancer syndrome. This syndrome is usually due to germline mutations in the BRCA1- or BRCA2-gene. Ovarian and endometrial cancer also occur in families with hereditary non-polyposis colorectal cancer (HNPCC). This syndrome is caused by germline mutations in DNA mismatch-repair genes. Women at high risk of gynaecological cancer based upon familial clustering of disease or a demonstrated pathogenic germ-line mutation are candidates for surveillance: annual gynaecological examinations, including vaginal echoscopy and serum carcinoma antigen CA125 testing. Prophylactic surgery in the form of adnexectomy leads to a marked, but not complete, reduction of ovarian-cancer risk in high-risk cases. There is insufficient evidence to advise against the use of oral contraceptives or hormonal substitution after adnexectomy for healthy women with a genetic predisposition to breast cancer. Recommendations for surveillance and prevention should only be given after genetic-risk counselling, based on a detailed family study and DNA-based diagnosis. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/12518519/[Recommendations_for_the_management_of_women_with_an_increased_genetic_risk_of_gynaecological_cancer]_ L2 - https://medlineplus.gov/ovariancancer.html DB - PRIME DP - Unbound Medicine ER -