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Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men.
N Engl J Med 2003; 348(2):109-18NEJM

Abstract

BACKGROUND

Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear.

METHODS

We studied the association of alcohol consumption with the risk of myocardial infarction among 38,077 male health professionals who were free of cardiovascular disease and cancer at base line. We assessed the consumption of beer, red wine, white wine, and liquor individually every four years using validated food-frequency questionnaires. We documented cases of nonfatal myocardial infarction and fatal coronary heart disease from 1986 to 1998.

RESULTS

During 12 years of follow-up, there were 1418 cases of myocardial infarction. As compared with men who consumed alcohol less than once per week, men who consumed alcohol three to four or five to seven days per week had decreased risks of myocardial infarction (multivariate relative risk, 0.68 [95 percent confidence interval, 0.55 to 0.84] and 0.63 [95 percent confidence interval, 0.54 to 0.74], respectively). The risk was similar among men who consumed less than 10 g of alcohol per drinking day and those who consumed 30 g or more. No single type of beverage conferred additional benefit, nor did consumption with meals. A 12.5-g increase in daily alcohol consumption over a four-year follow-up period was associated with a relative risk of myocardial infarction of 0.78 (95 percent confidence interval, 0.62 to 0.99).

CONCLUSIONS

Among men, consumption of alcohol at least three to four days per week was inversely associated with the risk of myocardial infarction. Neither the type of beverage nor the proportion consumed with meals substantially altered this association. Men who increased their alcohol consumption by a moderate amount during follow-up had a decreased risk of myocardial infarction.

Authors+Show Affiliations

Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. kmukamal@caregroup.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12519921

Citation

Mukamal, Kenneth J., et al. "Roles of Drinking Pattern and Type of Alcohol Consumed in Coronary Heart Disease in Men." The New England Journal of Medicine, vol. 348, no. 2, 2003, pp. 109-18.
Mukamal KJ, Conigrave KM, Mittleman MA, et al. Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med. 2003;348(2):109-18.
Mukamal, K. J., Conigrave, K. M., Mittleman, M. A., Camargo, C. A., Stampfer, M. J., Willett, W. C., & Rimm, E. B. (2003). Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. The New England Journal of Medicine, 348(2), pp. 109-18.
Mukamal KJ, et al. Roles of Drinking Pattern and Type of Alcohol Consumed in Coronary Heart Disease in Men. N Engl J Med. 2003 Jan 9;348(2):109-18. PubMed PMID: 12519921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. AU - Mukamal,Kenneth J, AU - Conigrave,Katherine M, AU - Mittleman,Murray A, AU - Camargo,Carlos A,Jr AU - Stampfer,Meir J, AU - Willett,Walter C, AU - Rimm,Eric B, PY - 2003/1/10/pubmed PY - 2003/1/16/medline PY - 2003/1/10/entrez SP - 109 EP - 18 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 348 IS - 2 N2 - BACKGROUND: Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear. METHODS: We studied the association of alcohol consumption with the risk of myocardial infarction among 38,077 male health professionals who were free of cardiovascular disease and cancer at base line. We assessed the consumption of beer, red wine, white wine, and liquor individually every four years using validated food-frequency questionnaires. We documented cases of nonfatal myocardial infarction and fatal coronary heart disease from 1986 to 1998. RESULTS: During 12 years of follow-up, there were 1418 cases of myocardial infarction. As compared with men who consumed alcohol less than once per week, men who consumed alcohol three to four or five to seven days per week had decreased risks of myocardial infarction (multivariate relative risk, 0.68 [95 percent confidence interval, 0.55 to 0.84] and 0.63 [95 percent confidence interval, 0.54 to 0.74], respectively). The risk was similar among men who consumed less than 10 g of alcohol per drinking day and those who consumed 30 g or more. No single type of beverage conferred additional benefit, nor did consumption with meals. A 12.5-g increase in daily alcohol consumption over a four-year follow-up period was associated with a relative risk of myocardial infarction of 0.78 (95 percent confidence interval, 0.62 to 0.99). CONCLUSIONS: Among men, consumption of alcohol at least three to four days per week was inversely associated with the risk of myocardial infarction. Neither the type of beverage nor the proportion consumed with meals substantially altered this association. Men who increased their alcohol consumption by a moderate amount during follow-up had a decreased risk of myocardial infarction. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/12519921/Roles_of_drinking_pattern_and_type_of_alcohol_consumed_in_coronary_heart_disease_in_men_ L2 - http://www.nejm.org/doi/full/10.1056/NEJMoa022095?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -