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    Blood pressure, hematologic and erythrocyte fragility changes in children suffering from sickle cell anemia following ascorbic acid supplementation.

    Abstract

    The effect of ascorbic acid supplementation (100 mg/day for 6 weeks) on blood pressure, packed cell volume, irreversibly sickled cells, per cent fetal hemoglobin, hemoglobin concentration, and erythrocyte osmotic fragility was assessed in children suffering from sickle cell anemia. Fifteen children whose ages ranged from 4 to 11 years (7.5 +/- 0.75 years) were studied. Ascorbic acid supplementation reduced systolic blood pressure by 10.9 +/- 3.4 mmHg (p < 0.01), diastolic blood pressure by 7.3 +/- 2.0 mmHg (p < 0.01) and mean arterial pressure by 9.4 +/- 2.6 mmHg (p < 0.01). It significantly increased packed cell volume (p < 0.001), hemoglobin concentration (p < 0.001) and per cent fetal hemoglobin (p < 0.001), but reduced per cent irreversibly sickled cells (p < 0.001). Ascorbic acid supplementation also abolished the long tail of the erythrocyte osmotic fragiligram and increased the resistance of the cells to lysis.

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    Authors

    Jaja SI
    ,
    Ikotun AR
    ,
    Gbenebitse S
    ,
    Temiye EO

    Source

    Journal of tropical pediatrics 48:6 2002 Dec pg 366-70

    MeSH

    Anemia, Sickle Cell
    Ascorbic Acid
    Blood Pressure
    Child
    Child, Preschool
    Data Interpretation, Statistical
    Erythrocytes, Abnormal
    Female
    Fetal Hemoglobin
    Hematocrit
    Humans
    Male
    Nigeria
    Osmotic Fragility

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12521281

    Citation

    TY - JOUR T1 - Blood pressure, hematologic and erythrocyte fragility changes in children suffering from sickle cell anemia following ascorbic acid supplementation. AU - Jaja,S I, AU - Ikotun,A R, AU - Gbenebitse,S, AU - Temiye,E O, PY - 2003/1/11/pubmed PY - 2003/2/13/medline PY - 2003/1/11/entrez SP - 366 EP - 70 JF - Journal of tropical pediatrics JO - J. Trop. Pediatr. VL - 48 IS - 6 N2 - The effect of ascorbic acid supplementation (100 mg/day for 6 weeks) on blood pressure, packed cell volume, irreversibly sickled cells, per cent fetal hemoglobin, hemoglobin concentration, and erythrocyte osmotic fragility was assessed in children suffering from sickle cell anemia. Fifteen children whose ages ranged from 4 to 11 years (7.5 +/- 0.75 years) were studied. Ascorbic acid supplementation reduced systolic blood pressure by 10.9 +/- 3.4 mmHg (p < 0.01), diastolic blood pressure by 7.3 +/- 2.0 mmHg (p < 0.01) and mean arterial pressure by 9.4 +/- 2.6 mmHg (p < 0.01). It significantly increased packed cell volume (p < 0.001), hemoglobin concentration (p < 0.001) and per cent fetal hemoglobin (p < 0.001), but reduced per cent irreversibly sickled cells (p < 0.001). Ascorbic acid supplementation also abolished the long tail of the erythrocyte osmotic fragiligram and increased the resistance of the cells to lysis. SN - 0142-6338 UR - https://www.unboundmedicine.com/medline/citation/12521281/full_citation L2 - http://tropej.oxfordjournals.org/cgi/pmidlookup?view=long&amp;pmid=12521281 ER -