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Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma.
Blood 2003; 101(9):3407-12Blood

Abstract

The importance of alpha beta versus gamma delta T-cell subset antigen expression in the classification of peripheral T-cell lymphomas is still unclear. The objective of this study was to investigate the prognostic value of T-cell receptor-delta 1 (TCR delta 1) expression in primary cutaneous T-cell lymphomas. TCR delta 1 cellular expression was assessed in skin biopsy specimens of 104 individuals with cutaneous T-cell lymphoma by immunohistochemistry. Both univariate (Kaplan-Meier) and multivariate (Cox regression) analyses were conducted to determine which variables (T-cell subtype, hemophagocytosis, histologic profile, age, sex, and adenopathy) were significantly associated with survival. Univariate analysis indicated that there was a statistically significant difference in survival between the patients with alpha beta cutaneous T-cell lymphoma and patients with gamma delta cutaneous T-cell lymphoma (P <.0001). There was also a statistically significant decrease in survival among patients who had subcutaneous involvement compared with patients who had epidermotropic and/or dermal involvement (P <.0001). Cox model analysis indicated that TCR delta 1 expression was the factor that was most closely associated with decreased survival (P <.0001). Among those patients with cutaneous gamma delta T-cell lymphoma (n = 33), there was a trend for decreased survival for patients who had histologic evidence of subcutaneous fat involvement in comparison with patients who had epidermotropic or dermal patterns of infiltration (P =.067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. TCR delta 1 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival.

Authors+Show Affiliations

Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7231, USA. torojo@exchange.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12522013

Citation

Toro, Jorge R., et al. "Gamma-delta T-cell Phenotype Is Associated With Significantly Decreased Survival in Cutaneous T-cell Lymphoma." Blood, vol. 101, no. 9, 2003, pp. 3407-12.
Toro JR, Liewehr DJ, Pabby N, et al. Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma. Blood. 2003;101(9):3407-12.
Toro, J. R., Liewehr, D. J., Pabby, N., Sorbara, L., Raffeld, M., Steinberg, S. M., & Jaffe, E. S. (2003). Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma. Blood, 101(9), pp. 3407-12.
Toro JR, et al. Gamma-delta T-cell Phenotype Is Associated With Significantly Decreased Survival in Cutaneous T-cell Lymphoma. Blood. 2003 May 1;101(9):3407-12. PubMed PMID: 12522013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma. AU - Toro,Jorge R, AU - Liewehr,David J, AU - Pabby,Nina, AU - Sorbara,Lynn, AU - Raffeld,Mark, AU - Steinberg,Seth M, AU - Jaffe,Elaine S, Y1 - 2003/01/09/ PY - 2003/1/11/pubmed PY - 2003/6/21/medline PY - 2003/1/11/entrez SP - 3407 EP - 12 JF - Blood JO - Blood VL - 101 IS - 9 N2 - The importance of alpha beta versus gamma delta T-cell subset antigen expression in the classification of peripheral T-cell lymphomas is still unclear. The objective of this study was to investigate the prognostic value of T-cell receptor-delta 1 (TCR delta 1) expression in primary cutaneous T-cell lymphomas. TCR delta 1 cellular expression was assessed in skin biopsy specimens of 104 individuals with cutaneous T-cell lymphoma by immunohistochemistry. Both univariate (Kaplan-Meier) and multivariate (Cox regression) analyses were conducted to determine which variables (T-cell subtype, hemophagocytosis, histologic profile, age, sex, and adenopathy) were significantly associated with survival. Univariate analysis indicated that there was a statistically significant difference in survival between the patients with alpha beta cutaneous T-cell lymphoma and patients with gamma delta cutaneous T-cell lymphoma (P <.0001). There was also a statistically significant decrease in survival among patients who had subcutaneous involvement compared with patients who had epidermotropic and/or dermal involvement (P <.0001). Cox model analysis indicated that TCR delta 1 expression was the factor that was most closely associated with decreased survival (P <.0001). Among those patients with cutaneous gamma delta T-cell lymphoma (n = 33), there was a trend for decreased survival for patients who had histologic evidence of subcutaneous fat involvement in comparison with patients who had epidermotropic or dermal patterns of infiltration (P =.067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. TCR delta 1 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/12522013/Gamma_delta_T_cell_phenotype_is_associated_with_significantly_decreased_survival_in_cutaneous_T_cell_lymphoma_ L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&amp;pmid=12522013 DB - PRIME DP - Unbound Medicine ER -