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Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects.
Metabolism. 2003 Jan; 52(1):50-9.M

Abstract

In this study, we concurrently examined the effects of 8 and 40 weeks of growth hormone replacement (GHR) on lipids, lipoprotein composition, low-density lipoprotein (LDL) size, very-low-density lipoprotein (VLDL) apolipoprotein (apo)B kinetics and LDL apoB kinetics. Eight weeks of GHR did not alter lipid profiles. Forty weeks of GHR increased high-density lipoprotein-cholesterol (HDL-C) concentration (P =.01), nonsignificantly reduced LDL-C (P =.06), and reduced the HDL/LDL-C ratio (P =.04). Forty weeks of GHR increased HDL free cholesterol (P =.03), total cholesterol (P =.01), and cholesterol ester (P <.01) concentrations. No other significant changes in VLDL, LDL, or HDL composition or LDL size were noted at any time. Eight weeks of GHR reduced VLDL apoB absolute secretion rate (ASR, P =.03), with nonsignificant reductions in fractional secretion rate (FSR, P =.09) and pool size (P =.09). After 40 weeks of GHR, the VLDL apoB ASR, FSR, and pool size were not significantly different from baseline. Forty weeks of GHR increased both LDL apoB FSR (P =.02) and LDL apoB ASR (P =.04), with a small decrease in pool size. Thus, GHR may have important antiatherogenic effects; HDL-C increased, LDL-C was nonsignificantly reduced, the total/HDL-C ratio was reduced, VLDL apoB production was reduced, and LDL apoB turnover was increased.

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Authors+Show Affiliations

Kearney T
Department of Metabolic Medicine, St. Mary's Hospital Campus, London, UK.
de Gallegos CN
No affiliation info available
Proudler A
No affiliation info available
Parker K
No affiliation info available
Anayaoku V
No affiliation info available
Bannister P
No affiliation info available
Venkatesan S
No affiliation info available
Johnston DG
No affiliation info available

MeSH

AdultAgedAlgorithmsApolipoproteins BBody Mass IndexDouble-Blind MethodFemaleGrowth HormoneHuman Growth HormoneHumansHypopituitarismKeto AcidsKineticsLipoproteinsLipoproteins, LDLLipoproteins, VLDLMaleMiddle AgedParticle SizeReceptors, Somatotropin

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12524662

Citation

Kearney, Tara, et al. "Effects of Short- and Long-term Growth Hormone Replacement On Lipoprotein Composition and On Very-low-density Lipoprotein and Low-density Lipoprotein Apolipoprotein B100 Kinetics in Growth Hormone-deficient Hypopituitary Subjects." Metabolism: Clinical and Experimental, vol. 52, no. 1, 2003, pp. 50-9.
Kearney T, de Gallegos CN, Proudler A, et al. Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects. Metabolism. 2003;52(1):50-9.
Kearney, T., de Gallegos, C. N., Proudler, A., Parker, K., Anayaoku, V., Bannister, P., Venkatesan, S., & Johnston, D. G. (2003). Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects. Metabolism: Clinical and Experimental, 52(1), 50-9.
Kearney T, et al. Effects of Short- and Long-term Growth Hormone Replacement On Lipoprotein Composition and On Very-low-density Lipoprotein and Low-density Lipoprotein Apolipoprotein B100 Kinetics in Growth Hormone-deficient Hypopituitary Subjects. Metabolism. 2003;52(1):50-9. PubMed PMID: 12524662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects. AU - Kearney,Tara, AU - de Gallegos,Carmen Navas, AU - Proudler,Anthony, AU - Parker,Kim, AU - Anayaoku,Victor, AU - Bannister,Peter, AU - Venkatesan,Soundararajan, AU - Johnston,Desmond G, PY - 2003/1/14/pubmed PY - 2003/2/1/medline PY - 2003/1/14/entrez SP - 50 EP - 9 JF - Metabolism: clinical and experimental JO - Metabolism VL - 52 IS - 1 N2 - In this study, we concurrently examined the effects of 8 and 40 weeks of growth hormone replacement (GHR) on lipids, lipoprotein composition, low-density lipoprotein (LDL) size, very-low-density lipoprotein (VLDL) apolipoprotein (apo)B kinetics and LDL apoB kinetics. Eight weeks of GHR did not alter lipid profiles. Forty weeks of GHR increased high-density lipoprotein-cholesterol (HDL-C) concentration (P =.01), nonsignificantly reduced LDL-C (P =.06), and reduced the HDL/LDL-C ratio (P =.04). Forty weeks of GHR increased HDL free cholesterol (P =.03), total cholesterol (P =.01), and cholesterol ester (P <.01) concentrations. No other significant changes in VLDL, LDL, or HDL composition or LDL size were noted at any time. Eight weeks of GHR reduced VLDL apoB absolute secretion rate (ASR, P =.03), with nonsignificant reductions in fractional secretion rate (FSR, P =.09) and pool size (P =.09). After 40 weeks of GHR, the VLDL apoB ASR, FSR, and pool size were not significantly different from baseline. Forty weeks of GHR increased both LDL apoB FSR (P =.02) and LDL apoB ASR (P =.04), with a small decrease in pool size. Thus, GHR may have important antiatherogenic effects; HDL-C increased, LDL-C was nonsignificantly reduced, the total/HDL-C ratio was reduced, VLDL apoB production was reduced, and LDL apoB turnover was increased. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/12524662/Effects_of_short__and_long_term_growth_hormone_replacement_on_lipoprotein_composition_and_on_very_low_density_lipoprotein_and_low_density_lipoprotein_apolipoprotein_B100_kinetics_in_growth_hormone_deficient_hypopituitary_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049503500117 DB - PRIME DP - Unbound Medicine ER -