Tags

Type your tag names separated by a space and hit enter

Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects.
Metabolism. 2003 Jan; 52(1):50-9.M

Abstract

In this study, we concurrently examined the effects of 8 and 40 weeks of growth hormone replacement (GHR) on lipids, lipoprotein composition, low-density lipoprotein (LDL) size, very-low-density lipoprotein (VLDL) apolipoprotein (apo)B kinetics and LDL apoB kinetics. Eight weeks of GHR did not alter lipid profiles. Forty weeks of GHR increased high-density lipoprotein-cholesterol (HDL-C) concentration (P =.01), nonsignificantly reduced LDL-C (P =.06), and reduced the HDL/LDL-C ratio (P =.04). Forty weeks of GHR increased HDL free cholesterol (P =.03), total cholesterol (P =.01), and cholesterol ester (P <.01) concentrations. No other significant changes in VLDL, LDL, or HDL composition or LDL size were noted at any time. Eight weeks of GHR reduced VLDL apoB absolute secretion rate (ASR, P =.03), with nonsignificant reductions in fractional secretion rate (FSR, P =.09) and pool size (P =.09). After 40 weeks of GHR, the VLDL apoB ASR, FSR, and pool size were not significantly different from baseline. Forty weeks of GHR increased both LDL apoB FSR (P =.02) and LDL apoB ASR (P =.04), with a small decrease in pool size. Thus, GHR may have important antiatherogenic effects; HDL-C increased, LDL-C was nonsignificantly reduced, the total/HDL-C ratio was reduced, VLDL apoB production was reduced, and LDL apoB turnover was increased.

Authors+Show Affiliations

Department of Metabolic Medicine, St. Mary's Hospital Campus, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12524662

Citation

Kearney, Tara, et al. "Effects of Short- and Long-term Growth Hormone Replacement On Lipoprotein Composition and On Very-low-density Lipoprotein and Low-density Lipoprotein Apolipoprotein B100 Kinetics in Growth Hormone-deficient Hypopituitary Subjects." Metabolism: Clinical and Experimental, vol. 52, no. 1, 2003, pp. 50-9.
Kearney T, de Gallegos CN, Proudler A, et al. Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects. Metab Clin Exp. 2003;52(1):50-9.
Kearney, T., de Gallegos, C. N., Proudler, A., Parker, K., Anayaoku, V., Bannister, P., Venkatesan, S., & Johnston, D. G. (2003). Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects. Metabolism: Clinical and Experimental, 52(1), 50-9.
Kearney T, et al. Effects of Short- and Long-term Growth Hormone Replacement On Lipoprotein Composition and On Very-low-density Lipoprotein and Low-density Lipoprotein Apolipoprotein B100 Kinetics in Growth Hormone-deficient Hypopituitary Subjects. Metab Clin Exp. 2003;52(1):50-9. PubMed PMID: 12524662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects. AU - Kearney,Tara, AU - de Gallegos,Carmen Navas, AU - Proudler,Anthony, AU - Parker,Kim, AU - Anayaoku,Victor, AU - Bannister,Peter, AU - Venkatesan,Soundararajan, AU - Johnston,Desmond G, PY - 2003/1/14/pubmed PY - 2003/2/1/medline PY - 2003/1/14/entrez SP - 50 EP - 9 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 52 IS - 1 N2 - In this study, we concurrently examined the effects of 8 and 40 weeks of growth hormone replacement (GHR) on lipids, lipoprotein composition, low-density lipoprotein (LDL) size, very-low-density lipoprotein (VLDL) apolipoprotein (apo)B kinetics and LDL apoB kinetics. Eight weeks of GHR did not alter lipid profiles. Forty weeks of GHR increased high-density lipoprotein-cholesterol (HDL-C) concentration (P =.01), nonsignificantly reduced LDL-C (P =.06), and reduced the HDL/LDL-C ratio (P =.04). Forty weeks of GHR increased HDL free cholesterol (P =.03), total cholesterol (P =.01), and cholesterol ester (P <.01) concentrations. No other significant changes in VLDL, LDL, or HDL composition or LDL size were noted at any time. Eight weeks of GHR reduced VLDL apoB absolute secretion rate (ASR, P =.03), with nonsignificant reductions in fractional secretion rate (FSR, P =.09) and pool size (P =.09). After 40 weeks of GHR, the VLDL apoB ASR, FSR, and pool size were not significantly different from baseline. Forty weeks of GHR increased both LDL apoB FSR (P =.02) and LDL apoB ASR (P =.04), with a small decrease in pool size. Thus, GHR may have important antiatherogenic effects; HDL-C increased, LDL-C was nonsignificantly reduced, the total/HDL-C ratio was reduced, VLDL apoB production was reduced, and LDL apoB turnover was increased. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/12524662/Effects_of_short__and_long_term_growth_hormone_replacement_on_lipoprotein_composition_and_on_very_low_density_lipoprotein_and_low_density_lipoprotein_apolipoprotein_B100_kinetics_in_growth_hormone_deficient_hypopituitary_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049503500117 DB - PRIME DP - Unbound Medicine ER -