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Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles.
Hum Reprod. 2003 Jan; 18(1):45-9.HR

Abstract

BACKGROUND

The introduction of GnRH antagonists such as cetrorelix acetate has made possible the simplification of ovarian stimulation. However, the most effective protocol for their administration has not yet been clearly defined.

METHODS

Forty women with male-factor infertility undergoing 40 ICSI cycles were included in the study. Clomiphene citrate at 100 mg a day was given from cycle day 3 through day 7. hMG at 150 IU was given on cycle days 4, 6 and 8, and was adjusted from day 9 according to the follicular and hormone responses. Cetrorelix acetate at 2.5 mg was administered when the leading follicle reached 14 mm. The remaining 0.5 mg was divided into two 0.25 mg injections for possible later use. Serum FSH, LH, estradiol and progesterone levels were measured daily from the day of cetrorelix acetate injection until hCG was given.

RESULTS

Serum LH level was suppressed effectively for 4 days. Four patients (10%) needed one or two additional injections of 0.25 mg cetrorelix acetate. No premature LH surge was detected in any of the women treated. Sixteen women became pregnant (40%), of which 14 pregnancies (35%) were ongoing at the time of writing.

CONCLUSIONS

This study demonstrates that this new protocol is feasible for couples with male-factor infertility undergoing ICSI.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12525439

Citation

Hwang, Jiann-Loung, et al. "Ovarian Stimulation By Clomiphene Citrate and hMG in Combination With Cetrorelix Acetate for ICSI Cycles." Human Reproduction (Oxford, England), vol. 18, no. 1, 2003, pp. 45-9.
Hwang JL, Huang LW, Hsieh BC, et al. Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles. Hum Reprod. 2003;18(1):45-9.
Hwang, J. L., Huang, L. W., Hsieh, B. C., Tsai, Y. L., Huang, S. C., Chen, C. Y., Hsieh, M. L., Chen, P. H., & Lin, Y. H. (2003). Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles. Human Reproduction (Oxford, England), 18(1), 45-9.
Hwang JL, et al. Ovarian Stimulation By Clomiphene Citrate and hMG in Combination With Cetrorelix Acetate for ICSI Cycles. Hum Reprod. 2003;18(1):45-9. PubMed PMID: 12525439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles. AU - Hwang,Jiann-Loung, AU - Huang,Lee-Wen, AU - Hsieh,Bih-Chwen, AU - Tsai,Yieh-Loong, AU - Huang,Shih-Chia, AU - Chen,Chin-Yu, AU - Hsieh,Mei-Ling, AU - Chen,Pei-Hsin, AU - Lin,Yu-Hung, PY - 2003/1/15/pubmed PY - 2003/8/2/medline PY - 2003/1/15/entrez SP - 45 EP - 9 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 18 IS - 1 N2 - BACKGROUND: The introduction of GnRH antagonists such as cetrorelix acetate has made possible the simplification of ovarian stimulation. However, the most effective protocol for their administration has not yet been clearly defined. METHODS: Forty women with male-factor infertility undergoing 40 ICSI cycles were included in the study. Clomiphene citrate at 100 mg a day was given from cycle day 3 through day 7. hMG at 150 IU was given on cycle days 4, 6 and 8, and was adjusted from day 9 according to the follicular and hormone responses. Cetrorelix acetate at 2.5 mg was administered when the leading follicle reached 14 mm. The remaining 0.5 mg was divided into two 0.25 mg injections for possible later use. Serum FSH, LH, estradiol and progesterone levels were measured daily from the day of cetrorelix acetate injection until hCG was given. RESULTS: Serum LH level was suppressed effectively for 4 days. Four patients (10%) needed one or two additional injections of 0.25 mg cetrorelix acetate. No premature LH surge was detected in any of the women treated. Sixteen women became pregnant (40%), of which 14 pregnancies (35%) were ongoing at the time of writing. CONCLUSIONS: This study demonstrates that this new protocol is feasible for couples with male-factor infertility undergoing ICSI. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/12525439/Ovarian_stimulation_by_clomiphene_citrate_and_hMG_in_combination_with_cetrorelix_acetate_for_ICSI_cycles_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deg021 DB - PRIME DP - Unbound Medicine ER -