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Clinical factors influencing the eosinophil infiltration of nasal polyps.
Rhinology. 2002 Dec; 40(4):173-8.R

Abstract

AIMS AND METHODS

Our study, based on a retrospective chart analysis, was aimed 1) to describe the varying degree of eosinophil infiltration in a series of 263 adult patients operated on diffuse and bilateral nasal polyposis (NPS) after failure of medical treatment, in 15 cystic fibrosis patients with bilateral nasal polyps, and in 31 patients with chronic sinusitis without polyps (18 bilateral, 13 unilateral) 2) to search for clinical factors that might influence the degree of eosinophil infiltration. Eosinophil infiltration was expressed semi-quantativity as a percentage of inflammatory cells.

RESULTS

Our study confirms that eosinophil infiltration is a striking feature of nasal polyposis. All patients with chronic sinusitis showed less than 10% eosinophils (mean +/- SEM = 2 +/- 2%) whereas 88% of patients with NPS showed more than 10% eosinophils (50 +/- 2%). Cystic fibrosis lied in between with 40% of patients showing more than 10% eosinophils. In idiopathic bilateral NPS the number of eosinophils was increased in patients with asthma (58 +/- 3%) and even more in Widal's triad (75 +/- 4%). Atopic patients did not have more eosinophils (52 +/- 5%). Patients treated with systemic steroids within two months before surgery showed decreased eosinophil infiltration (22 +/- 3% vs 50 +/- 2 for treated versus untreated) whereas patients treated with topical steroids did not (47 +/- 2%).

CONCLUSIONS

Thus, a link might exist between clinical presentation and eosinophil infiltration. Chronic sinusitis and nasal polyps are probably not the same disease. Eosinophils appear as a link between nasal polyps, asthma and aspirin intolerance. Atopic status does not modify eosinophil infiltration of nasal polyps. Systemic steroids appear significantly more effective to reduce the eosinophil infiltrate than topical steroids in our selected group of operated patients.

Authors+Show Affiliations

Jankowski R
Department of Otorhinolaryngology, Henri Poincaré University, CHU-Central Hospital, Nancy, France. r.jankowski@chu-nancy.fr
Bouchoua F
No affiliation info available
Coffinet L
No affiliation info available
Vignaud JM
No affiliation info available

MeSH

AdolescentAdultAgedChildEosinophilsFemaleHumansMaleMiddle AgedNasal PolypsRetrospective Studies

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12526243

Citation

Jankowski, R, et al. "Clinical Factors Influencing the Eosinophil Infiltration of Nasal Polyps." Rhinology, vol. 40, no. 4, 2002, pp. 173-8.
Jankowski R, Bouchoua F, Coffinet L, et al. Clinical factors influencing the eosinophil infiltration of nasal polyps. Rhinology. 2002;40(4):173-8.
Jankowski, R., Bouchoua, F., Coffinet, L., & Vignaud, J. M. (2002). Clinical factors influencing the eosinophil infiltration of nasal polyps. Rhinology, 40(4), 173-8.
Jankowski R, et al. Clinical Factors Influencing the Eosinophil Infiltration of Nasal Polyps. Rhinology. 2002;40(4):173-8. PubMed PMID: 12526243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical factors influencing the eosinophil infiltration of nasal polyps. AU - Jankowski,R, AU - Bouchoua,F, AU - Coffinet,L, AU - Vignaud,J M, PY - 2003/1/16/pubmed PY - 2003/4/16/medline PY - 2003/1/16/entrez SP - 173 EP - 8 JF - Rhinology JO - Rhinology VL - 40 IS - 4 N2 - AIMS AND METHODS: Our study, based on a retrospective chart analysis, was aimed 1) to describe the varying degree of eosinophil infiltration in a series of 263 adult patients operated on diffuse and bilateral nasal polyposis (NPS) after failure of medical treatment, in 15 cystic fibrosis patients with bilateral nasal polyps, and in 31 patients with chronic sinusitis without polyps (18 bilateral, 13 unilateral) 2) to search for clinical factors that might influence the degree of eosinophil infiltration. Eosinophil infiltration was expressed semi-quantativity as a percentage of inflammatory cells. RESULTS: Our study confirms that eosinophil infiltration is a striking feature of nasal polyposis. All patients with chronic sinusitis showed less than 10% eosinophils (mean +/- SEM = 2 +/- 2%) whereas 88% of patients with NPS showed more than 10% eosinophils (50 +/- 2%). Cystic fibrosis lied in between with 40% of patients showing more than 10% eosinophils. In idiopathic bilateral NPS the number of eosinophils was increased in patients with asthma (58 +/- 3%) and even more in Widal's triad (75 +/- 4%). Atopic patients did not have more eosinophils (52 +/- 5%). Patients treated with systemic steroids within two months before surgery showed decreased eosinophil infiltration (22 +/- 3% vs 50 +/- 2 for treated versus untreated) whereas patients treated with topical steroids did not (47 +/- 2%). CONCLUSIONS: Thus, a link might exist between clinical presentation and eosinophil infiltration. Chronic sinusitis and nasal polyps are probably not the same disease. Eosinophils appear as a link between nasal polyps, asthma and aspirin intolerance. Atopic status does not modify eosinophil infiltration of nasal polyps. Systemic steroids appear significantly more effective to reduce the eosinophil infiltrate than topical steroids in our selected group of operated patients. SN - 0300-0729 UR - https://www.unboundmedicine.com/medline/citation/12526243/Clinical_factors_influencing_the_eosinophil_infiltration_of_nasal_polyps_ DB - PRIME DP - Unbound Medicine ER -