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Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease.
Mod Pathol. 2003 Jan; 16(1):49-56.MP

Abstract

Steatohepatitis, of either alcoholic or nonalcoholic etiologies, is ultimately diagnosed by clinical-pathologic correlation and is characterized histologically by lesions that differ from the portal-based chronic inflammation and fibrosis of most other forms of chronic liver disease. With the increasing prevalence of steatohepatitis in our society, it is likely that some patients will have coexistent clinical and/or histopathologic findings of steatohepatitis concurrently with another form of liver disease. The aim of this study was to document clinical and histologic findings in biopsies in an academic referral center. Ninety-three non-allograft liver biopsies with lesions of both steatohepatitis and another liver disease were retrospectively identified in 85 patients. The finding of coexisting disease represented 5.5% of all hepatitis C biopsies and 4.0% of other forms of chronic liver disease in the 34 month time period. Clinical chart review of patients with concurrent disease showed the following: Group 1, patients with hepatitis C (n = 54); Group 2, patients with hepatitis C and prior or current history of more than 80 g/d alcohol consumption (n = 20); Group 3, patients with other forms of chronic liver disease (n = 11). Groups 1 and 3 had <10 g/d alcohol use. Obesity (body mass index >30) was noted in 75%, 60%, and 33% respectively, while 94%, 87% and 100% of patients were considered overweight (body mass index > or = 25). Diabetes was reported in 35%, 25%, and 9%. The concurrence of clinical and histologic features of steatohepatitis with another chronic liver disease may be a reflection of the frequency of steatohepatitis in the population at large.

Authors+Show Affiliations

Saint Louis University Liver Center Department of Pathology, Saint Louis University Health Sciences Center, St Louis, Missouri, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12527713

Citation

Brunt, Elizabeth M., et al. "Concurrence of Histologic Features of Steatohepatitis With Other Forms of Chronic Liver Disease." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 16, no. 1, 2003, pp. 49-56.
Brunt EM, Ramrakhiani S, Cordes BG, et al. Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease. Mod Pathol. 2003;16(1):49-56.
Brunt, E. M., Ramrakhiani, S., Cordes, B. G., Neuschwander-Tetri, B. A., Janney, C. G., Bacon, B. R., & Di Bisceglie, A. M. (2003). Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 16(1), 49-56.
Brunt EM, et al. Concurrence of Histologic Features of Steatohepatitis With Other Forms of Chronic Liver Disease. Mod Pathol. 2003;16(1):49-56. PubMed PMID: 12527713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease. AU - Brunt,Elizabeth M, AU - Ramrakhiani,Sunil, AU - Cordes,Barry G, AU - Neuschwander-Tetri,Brent A, AU - Janney,Christine G, AU - Bacon,Bruce R, AU - Di Bisceglie,Adrian M, PY - 2003/1/16/pubmed PY - 2003/7/11/medline PY - 2003/1/16/entrez SP - 49 EP - 56 JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc JO - Mod Pathol VL - 16 IS - 1 N2 - Steatohepatitis, of either alcoholic or nonalcoholic etiologies, is ultimately diagnosed by clinical-pathologic correlation and is characterized histologically by lesions that differ from the portal-based chronic inflammation and fibrosis of most other forms of chronic liver disease. With the increasing prevalence of steatohepatitis in our society, it is likely that some patients will have coexistent clinical and/or histopathologic findings of steatohepatitis concurrently with another form of liver disease. The aim of this study was to document clinical and histologic findings in biopsies in an academic referral center. Ninety-three non-allograft liver biopsies with lesions of both steatohepatitis and another liver disease were retrospectively identified in 85 patients. The finding of coexisting disease represented 5.5% of all hepatitis C biopsies and 4.0% of other forms of chronic liver disease in the 34 month time period. Clinical chart review of patients with concurrent disease showed the following: Group 1, patients with hepatitis C (n = 54); Group 2, patients with hepatitis C and prior or current history of more than 80 g/d alcohol consumption (n = 20); Group 3, patients with other forms of chronic liver disease (n = 11). Groups 1 and 3 had <10 g/d alcohol use. Obesity (body mass index >30) was noted in 75%, 60%, and 33% respectively, while 94%, 87% and 100% of patients were considered overweight (body mass index > or = 25). Diabetes was reported in 35%, 25%, and 9%. The concurrence of clinical and histologic features of steatohepatitis with another chronic liver disease may be a reflection of the frequency of steatohepatitis in the population at large. SN - 0893-3952 UR - https://www.unboundmedicine.com/medline/citation/12527713/Concurrence_of_histologic_features_of_steatohepatitis_with_other_forms_of_chronic_liver_disease_ L2 - https://doi.org/10.1097/01.MP.0000042420.21088.C7 DB - PRIME DP - Unbound Medicine ER -