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Osteopenia and osteoporosis in anorexia nervosa.
Adolesc Med 2003; 14(1):97-108AM

Abstract

Osteopenia is a frequent and severe complication of anorexia nervosa. Once established, it is difficult to treat and is only partially reversible. Osteoporosis is a preventable disease, and intervention should begin during childhood and adolescence. Optimizing peak bone mass accrual during adolescence is essential, and an episode of anorexia nervosa during adolescence interferes with that process. In anorexia nervosa, results with hormone replacement therapy have been disappointing. Calcium and vitamin D supplementation should be prescribed where necessary. Excessive exercise should be avoided and moderate weight-bearing exercise encouraged. Ongoing research studying newer modalities such as IGF-1, DHEA, and bisphosphonates looks promising. Until more effective treatment regimens become available, the mainstay of treatment remains weight gain, nutritional rehabilitation, and spontaneous resumption of menses.

Authors+Show Affiliations

Eating Disorders Center, Division of Adolescent Medicine, Schneider Children's Hospital, New Hyde Park, New York, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12529194

Citation

Golden, Neville H.. "Osteopenia and Osteoporosis in Anorexia Nervosa." Adolescent Medicine (Philadelphia, Pa.), vol. 14, no. 1, 2003, pp. 97-108.
Golden NH. Osteopenia and osteoporosis in anorexia nervosa. Adolesc Med. 2003;14(1):97-108.
Golden, N. H. (2003). Osteopenia and osteoporosis in anorexia nervosa. Adolescent Medicine (Philadelphia, Pa.), 14(1), pp. 97-108.
Golden NH. Osteopenia and Osteoporosis in Anorexia Nervosa. Adolesc Med. 2003;14(1):97-108. PubMed PMID: 12529194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteopenia and osteoporosis in anorexia nervosa. A1 - Golden,Neville H, PY - 2003/1/17/pubmed PY - 2003/8/28/medline PY - 2003/1/17/entrez SP - 97 EP - 108 JF - Adolescent medicine (Philadelphia, Pa.) JO - Adolesc Med VL - 14 IS - 1 N2 - Osteopenia is a frequent and severe complication of anorexia nervosa. Once established, it is difficult to treat and is only partially reversible. Osteoporosis is a preventable disease, and intervention should begin during childhood and adolescence. Optimizing peak bone mass accrual during adolescence is essential, and an episode of anorexia nervosa during adolescence interferes with that process. In anorexia nervosa, results with hormone replacement therapy have been disappointing. Calcium and vitamin D supplementation should be prescribed where necessary. Excessive exercise should be avoided and moderate weight-bearing exercise encouraged. Ongoing research studying newer modalities such as IGF-1, DHEA, and bisphosphonates looks promising. Until more effective treatment regimens become available, the mainstay of treatment remains weight gain, nutritional rehabilitation, and spontaneous resumption of menses. SN - 1041-3499 UR - https://www.unboundmedicine.com/medline/citation/12529194/Osteopenia_and_osteoporosis_in_anorexia_nervosa_ L2 - http://www.diseaseinfosearch.org/result/9059 DB - PRIME DP - Unbound Medicine ER -