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Diet and sex hormones in girls: findings from a randomized controlled clinical trial.
J Natl Cancer Inst. 2003 Jan 15; 95(2):132-41.JNCI

Abstract

BACKGROUND

Results of several studies have suggested that diet during adolescence may influence the risk of breast cancer in adulthood. We evaluated whether an intervention to lower fat intake among adolescent girls altered their serum concentrations of sex hormones that, in adults, are related to breast cancer development.

METHODS

We conducted an ancillary hormone study among 286 of the 301 girls who participated between 1988 and 1997 in the Dietary Intervention Study in Children, in which healthy, prepubertal, 8- to 10-year-olds with elevated low-density lipoprotein cholesterol were randomly assigned to usual care or to a behavioral intervention that promoted a low-fat diet. Median time on the intervention was 7 years. Blood samples collected before randomization and at the year 1, year 3, year 5, and last visits were assayed to determine the girls' serum levels of sex hormones. All P values are two-sided.

RESULTS

At the year 5 visit, girls in the intervention group had 29.8% (95% confidence interval [CI] = 5.4% to 47.9%; P =.02) lower estradiol, 30.2% (95% CI = 7.0% to 47.7%; P =.02) lower non-sex hormone binding globulin-bound estradiol, 20.7% (95% CI = 4.7% to 34.0%; P =.02) lower estrone, and 28.7% (95% CI = 5.1% to 46.5%; P =.02) lower estrone sulfate levels during the follicular phase of the menstrual cycle and 27.2% (95% CI = 5.7% to 53.1%; P =.01) higher testosterone levels during the luteal phase of the menstrual cycle than did girls in the usual care group. At the last visit, the luteal phase progesterone level was 52.9% (95% CI = 20.0% to 72.3%) lower for girls in the intervention group than for girls in the usual care group (P =.007).

CONCLUSION

Modest reductions in fat intake during puberty are associated with changes in sex hormone concentrations that are consistent with alterations in the function of the hypothalamic-pituitary-ovarian axis. Whether these changes influence breast cancer risk is currently unknown.

Authors+Show Affiliations

Fox Chase Cancer Center, Philadelphia, PA 19111, USA. jf_dorgan@fccc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12529346

Citation

Dorgan, Joanne F., et al. "Diet and Sex Hormones in Girls: Findings From a Randomized Controlled Clinical Trial." Journal of the National Cancer Institute, vol. 95, no. 2, 2003, pp. 132-41.
Dorgan JF, Hunsberger SA, McMahon RP, et al. Diet and sex hormones in girls: findings from a randomized controlled clinical trial. J Natl Cancer Inst. 2003;95(2):132-41.
Dorgan, J. F., Hunsberger, S. A., McMahon, R. P., Kwiterovich, P. O., Lauer, R. M., Van Horn, L., Lasser, N. L., Stevens, V. J., Friedman, L. A., Yanovski, J. A., Greenhut, S. F., Chandler, D. W., Franklin, F. A., Barton, B. A., Buckman, D. W., Snetselaar, L. G., Patterson, B. H., Schatzkin, A., & Taylor, P. R. (2003). Diet and sex hormones in girls: findings from a randomized controlled clinical trial. Journal of the National Cancer Institute, 95(2), 132-41.
Dorgan JF, et al. Diet and Sex Hormones in Girls: Findings From a Randomized Controlled Clinical Trial. J Natl Cancer Inst. 2003 Jan 15;95(2):132-41. PubMed PMID: 12529346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and sex hormones in girls: findings from a randomized controlled clinical trial. AU - Dorgan,Joanne F, AU - Hunsberger,Sally A, AU - McMahon,Robert P, AU - Kwiterovich,Peter O,Jr AU - Lauer,Ronald M, AU - Van Horn,Linda, AU - Lasser,Norman L, AU - Stevens,Victor J, AU - Friedman,Lisa A, AU - Yanovski,Jack A, AU - Greenhut,Susan F, AU - Chandler,Donald Walt, AU - Franklin,Frank A, AU - Barton,Bruce A, AU - Buckman,Dennis W, AU - Snetselaar,Linda G, AU - Patterson,Blossom H, AU - Schatzkin,Arthur, AU - Taylor,Philip R, PY - 2003/1/17/pubmed PY - 2003/2/7/medline PY - 2003/1/17/entrez SP - 132 EP - 41 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 95 IS - 2 N2 - BACKGROUND: Results of several studies have suggested that diet during adolescence may influence the risk of breast cancer in adulthood. We evaluated whether an intervention to lower fat intake among adolescent girls altered their serum concentrations of sex hormones that, in adults, are related to breast cancer development. METHODS: We conducted an ancillary hormone study among 286 of the 301 girls who participated between 1988 and 1997 in the Dietary Intervention Study in Children, in which healthy, prepubertal, 8- to 10-year-olds with elevated low-density lipoprotein cholesterol were randomly assigned to usual care or to a behavioral intervention that promoted a low-fat diet. Median time on the intervention was 7 years. Blood samples collected before randomization and at the year 1, year 3, year 5, and last visits were assayed to determine the girls' serum levels of sex hormones. All P values are two-sided. RESULTS: At the year 5 visit, girls in the intervention group had 29.8% (95% confidence interval [CI] = 5.4% to 47.9%; P =.02) lower estradiol, 30.2% (95% CI = 7.0% to 47.7%; P =.02) lower non-sex hormone binding globulin-bound estradiol, 20.7% (95% CI = 4.7% to 34.0%; P =.02) lower estrone, and 28.7% (95% CI = 5.1% to 46.5%; P =.02) lower estrone sulfate levels during the follicular phase of the menstrual cycle and 27.2% (95% CI = 5.7% to 53.1%; P =.01) higher testosterone levels during the luteal phase of the menstrual cycle than did girls in the usual care group. At the last visit, the luteal phase progesterone level was 52.9% (95% CI = 20.0% to 72.3%) lower for girls in the intervention group than for girls in the usual care group (P =.007). CONCLUSION: Modest reductions in fat intake during puberty are associated with changes in sex hormone concentrations that are consistent with alterations in the function of the hypothalamic-pituitary-ovarian axis. Whether these changes influence breast cancer risk is currently unknown. SN - 0027-8874 UR - https://www.unboundmedicine.com/medline/citation/12529346/Diet_and_sex_hormones_in_girls:_findings_from_a_randomized_controlled_clinical_trial_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/95.2.132 DB - PRIME DP - Unbound Medicine ER -