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Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance.
Anticancer Res 2002 Nov-Dec; 22(6A):3309-18AR

Abstract

The triterpenoid fraction (100 and 200 mg/kg) of the fruit bodies of Ganoderma lucidum inhibited primary solid-tumor growth in the spleen, liver metastasis and secondary metastatic tumor growth in the liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice. In addition, the triterpenoid fraction (800 micrograms/mL) inhibited angiogenesis induced by Matrigel (a soluble basement membrane extract of the Engelbreth-Holm-Swam (EHS) tumor) supplemented with vascular endothelial growth factor (VEGF) and heparin in an in vivo model. This suggested that the antitumor and antimetastatic activities of the triterpenoid fraction of G. lucidum might be due to the inhibition of tumor-induced angiogenesis. Next, we attempted to isolate the active substance(s) using the in vivo assay system of Matrigel-induced angiogenesis. The acidic fraction of the triterpenoid fraction inhibited the Matrigel-induced angiogenesis. Compound I was isolated from the acidic fraction as an active substance that inhibited the Martigel-induced angiogenesis. Compound I was identified as ganoderic acid F based on the data of IR, 1H- and 13C-NMR and MS analyses.

Authors+Show Affiliations

Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-095, Japan. yokim@m.ehimeu.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12530080

Citation

Kimura, Yoshiyuki, et al. "Antitumor and Antimetastatic Effects On Liver of Triterpenoid Fractions of Ganoderma Lucidum: Mechanism of Action and Isolation of an Active Substance." Anticancer Research, vol. 22, no. 6A, 2002, pp. 3309-18.
Kimura Y, Taniguchi M, Baba K. Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res. 2002;22(6A):3309-18.
Kimura, Y., Taniguchi, M., & Baba, K. (2002). Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Research, 22(6A), pp. 3309-18.
Kimura Y, Taniguchi M, Baba K. Antitumor and Antimetastatic Effects On Liver of Triterpenoid Fractions of Ganoderma Lucidum: Mechanism of Action and Isolation of an Active Substance. Anticancer Res. 2002;22(6A):3309-18. PubMed PMID: 12530080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. AU - Kimura,Yoshiyuki, AU - Taniguchi,Masahiko, AU - Baba,Kimiye, PY - 2003/1/18/pubmed PY - 2003/2/1/medline PY - 2003/1/18/entrez SP - 3309 EP - 18 JF - Anticancer research JO - Anticancer Res. VL - 22 IS - 6A N2 - The triterpenoid fraction (100 and 200 mg/kg) of the fruit bodies of Ganoderma lucidum inhibited primary solid-tumor growth in the spleen, liver metastasis and secondary metastatic tumor growth in the liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice. In addition, the triterpenoid fraction (800 micrograms/mL) inhibited angiogenesis induced by Matrigel (a soluble basement membrane extract of the Engelbreth-Holm-Swam (EHS) tumor) supplemented with vascular endothelial growth factor (VEGF) and heparin in an in vivo model. This suggested that the antitumor and antimetastatic activities of the triterpenoid fraction of G. lucidum might be due to the inhibition of tumor-induced angiogenesis. Next, we attempted to isolate the active substance(s) using the in vivo assay system of Matrigel-induced angiogenesis. The acidic fraction of the triterpenoid fraction inhibited the Matrigel-induced angiogenesis. Compound I was isolated from the acidic fraction as an active substance that inhibited the Martigel-induced angiogenesis. Compound I was identified as ganoderic acid F based on the data of IR, 1H- and 13C-NMR and MS analyses. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/12530080/Antitumor_and_antimetastatic_effects_on_liver_of_triterpenoid_fractions_of_Ganoderma_lucidum:_mechanism_of_action_and_isolation_of_an_active_substance_ DB - PRIME DP - Unbound Medicine ER -