Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches.J Membr Biol. 2003 Jan 01; 191(1):1-12.JM
Abstract
Copper is an essential trace element that plays a very important role in cell physiology. In humans, disruption of normal copper homeostasis leads to severe disorders, such as Menkes disease and Wilson's disease. Recent genetic, cell biological, and biochemical studies have begun to dissect the molecular mechanisms involved in transmembrane transport and intracellular distribution of copper in mammalian cells. In this review, we summarize the advances that have been made in understanding of structure, function, and regulation of the key human copper transporters, the Menkes disease and Wilson's disease proteins.
Links
MeSH
Adenosine TriphosphatasesAmino Acid SequenceAnimalsBiological Transport, ActiveCation Transport ProteinsCopperCopper-Transporting ATPasesHepatolenticular DegenerationHomeostasisHumansMammalsMenkes Kinky Hair SyndromeMolecular Sequence DataProtein ConformationRecombinant Fusion ProteinsStructure-Activity Relationship
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Language
eng
PubMed ID
12532272
Citation
Lutsenko, S, and M J. Petris. "Function and Regulation of the Mammalian Copper-transporting ATPases: Insights From Biochemical and Cell Biological Approaches." The Journal of Membrane Biology, vol. 191, no. 1, 2003, pp. 1-12.
Lutsenko S, Petris MJ. Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches. J Membr Biol. 2003;191(1):1-12.
Lutsenko, S., & Petris, M. J. (2003). Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches. The Journal of Membrane Biology, 191(1), 1-12.
Lutsenko S, Petris MJ. Function and Regulation of the Mammalian Copper-transporting ATPases: Insights From Biochemical and Cell Biological Approaches. J Membr Biol. 2003 Jan 1;191(1):1-12. PubMed PMID: 12532272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches.
AU - Lutsenko,S,
AU - Petris,M J,
PY - 2002/05/29/received
PY - 2003/1/18/pubmed
PY - 2003/10/1/medline
PY - 2003/1/18/entrez
SP - 1
EP - 12
JF - The Journal of membrane biology
JO - J Membr Biol
VL - 191
IS - 1
N2 - Copper is an essential trace element that plays a very important role in cell physiology. In humans, disruption of normal copper homeostasis leads to severe disorders, such as Menkes disease and Wilson's disease. Recent genetic, cell biological, and biochemical studies have begun to dissect the molecular mechanisms involved in transmembrane transport and intracellular distribution of copper in mammalian cells. In this review, we summarize the advances that have been made in understanding of structure, function, and regulation of the key human copper transporters, the Menkes disease and Wilson's disease proteins.
SN - 0022-2631
UR - https://www.unboundmedicine.com/medline/citation/12532272/Function_and_regulation_of_the_mammalian_copper_transporting_ATPases:_insights_from_biochemical_and_cell_biological_approaches_
L2 - https://dx.doi.org/10.1007/s00232-002-1040-6
DB - PRIME
DP - Unbound Medicine
ER -