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Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches.
J Membr Biol. 2003 Jan 01; 191(1):1-12.JM

Abstract

Copper is an essential trace element that plays a very important role in cell physiology. In humans, disruption of normal copper homeostasis leads to severe disorders, such as Menkes disease and Wilson's disease. Recent genetic, cell biological, and biochemical studies have begun to dissect the molecular mechanisms involved in transmembrane transport and intracellular distribution of copper in mammalian cells. In this review, we summarize the advances that have been made in understanding of structure, function, and regulation of the key human copper transporters, the Menkes disease and Wilson's disease proteins.

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Authors+Show Affiliations

Lutsenko S
Department of Biochemistry and Molecular Biology, Oregon Health & Science University, 3181 Sam Jackson Park Rd, Portland, OR 97201, USA. Lutsenko@ohsu.edu
Petris MJ
No affiliation info available

MeSH

Adenosine TriphosphatasesAmino Acid SequenceAnimalsBiological Transport, ActiveCation Transport ProteinsCopperCopper-Transporting ATPasesHepatolenticular DegenerationHomeostasisHumansMammalsMenkes Kinky Hair SyndromeMolecular Sequence DataProtein ConformationRecombinant Fusion ProteinsStructure-Activity Relationship

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12532272

Citation

Lutsenko, S, and M J. Petris. "Function and Regulation of the Mammalian Copper-transporting ATPases: Insights From Biochemical and Cell Biological Approaches." The Journal of Membrane Biology, vol. 191, no. 1, 2003, pp. 1-12.
Lutsenko S, Petris MJ. Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches. J Membr Biol. 2003;191(1):1-12.
Lutsenko, S., & Petris, M. J. (2003). Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches. The Journal of Membrane Biology, 191(1), 1-12.
Lutsenko S, Petris MJ. Function and Regulation of the Mammalian Copper-transporting ATPases: Insights From Biochemical and Cell Biological Approaches. J Membr Biol. 2003 Jan 1;191(1):1-12. PubMed PMID: 12532272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches. AU - Lutsenko,S, AU - Petris,M J, PY - 2002/05/29/received PY - 2003/1/18/pubmed PY - 2003/10/1/medline PY - 2003/1/18/entrez SP - 1 EP - 12 JF - The Journal of membrane biology JO - J. Membr. Biol. VL - 191 IS - 1 N2 - Copper is an essential trace element that plays a very important role in cell physiology. In humans, disruption of normal copper homeostasis leads to severe disorders, such as Menkes disease and Wilson's disease. Recent genetic, cell biological, and biochemical studies have begun to dissect the molecular mechanisms involved in transmembrane transport and intracellular distribution of copper in mammalian cells. In this review, we summarize the advances that have been made in understanding of structure, function, and regulation of the key human copper transporters, the Menkes disease and Wilson's disease proteins. SN - 0022-2631 UR - https://www.unboundmedicine.com/medline/citation/12532272/Function_and_regulation_of_the_mammalian_copper_transporting_ATPases:_insights_from_biochemical_and_cell_biological_approaches_ L2 - https://dx.doi.org/10.1007/s00232-002-1040-6 DB - PRIME DP - Unbound Medicine ER -