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Prospects for cannabinoids as anti-inflammatory agents.

Abstract

The marijuana plant (Cannabis sativa) and preparations derived from it have been used for medicinal purposes for thousands of years. It is likely that the therapeutic benefits of smoked marijuana are due to some combination of its more than 60 cannabinoids and 200-250 non-cannabinoid constituents. Several marijuana constituents, the carboxylic acid metabolites of tetrahydrocannabinol, and synthetic analogs are free of cannabimimetic central nervous system activity, do not produce behavioral changes in humans, and are effective antiinflammatory and analgesic agents. One cannabinoid acid in particular, ajulemic acid, has been studied extensively in in vitro systems and animal models of inflammation and immune responses. This commentary reviews a portion of the work done by investigators interested in separating the medicinal properties of marijuana from its psychoactive effects. Understanding the mechanisms of the therapeutic effects of nonpsychoactive cannabinoids should lead to development of safe effective treatment for several diseases, and may render moot the debate about "medical marijuana".

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, USA. robert.zurier@umassmed.edu

    Source

    Journal of cellular biochemistry 88:3 2003 Feb 15 pg 462-6

    MeSH

    Animals
    Anti-Inflammatory Agents
    Behavior
    Cannabinoids
    Cannabis
    Humans
    Inflammation
    Molecular Structure

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12532323

    Citation

    Zurier, Robert B.. "Prospects for Cannabinoids as Anti-inflammatory Agents." Journal of Cellular Biochemistry, vol. 88, no. 3, 2003, pp. 462-6.
    Zurier RB. Prospects for cannabinoids as anti-inflammatory agents. J Cell Biochem. 2003;88(3):462-6.
    Zurier, R. B. (2003). Prospects for cannabinoids as anti-inflammatory agents. Journal of Cellular Biochemistry, 88(3), pp. 462-6.
    Zurier RB. Prospects for Cannabinoids as Anti-inflammatory Agents. J Cell Biochem. 2003 Feb 15;88(3):462-6. PubMed PMID: 12532323.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospects for cannabinoids as anti-inflammatory agents. A1 - Zurier,Robert B, PY - 2003/1/18/pubmed PY - 2004/3/24/medline PY - 2003/1/18/entrez SP - 462 EP - 6 JF - Journal of cellular biochemistry JO - J. Cell. Biochem. VL - 88 IS - 3 N2 - The marijuana plant (Cannabis sativa) and preparations derived from it have been used for medicinal purposes for thousands of years. It is likely that the therapeutic benefits of smoked marijuana are due to some combination of its more than 60 cannabinoids and 200-250 non-cannabinoid constituents. Several marijuana constituents, the carboxylic acid metabolites of tetrahydrocannabinol, and synthetic analogs are free of cannabimimetic central nervous system activity, do not produce behavioral changes in humans, and are effective antiinflammatory and analgesic agents. One cannabinoid acid in particular, ajulemic acid, has been studied extensively in in vitro systems and animal models of inflammation and immune responses. This commentary reviews a portion of the work done by investigators interested in separating the medicinal properties of marijuana from its psychoactive effects. Understanding the mechanisms of the therapeutic effects of nonpsychoactive cannabinoids should lead to development of safe effective treatment for several diseases, and may render moot the debate about "medical marijuana". SN - 0730-2312 UR - https://www.unboundmedicine.com/medline/citation/12532323/Prospects_for_cannabinoids_as_anti_inflammatory_agents_ L2 - https://doi.org/10.1002/jcb.10291 DB - PRIME DP - Unbound Medicine ER -