Tags

Type your tag names separated by a space and hit enter

Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH.
Aliment Pharmacol Ther. 2003 Jan; 17(2):243-51.AP

Abstract

BACKGROUND

Omeprazole controls acid but not non-acid reflux. The GABA B agonist baclofen decreases acid reflux through the inhibition of transient lower oesophageal sphincter relaxations (TLESRs) and should similarly decrease non-acid reflux. Using combined multichannel intraluminal impedance and pH (MII/pH), we compared acid and non-acid reflux after placebo and baclofen.

METHODS

Nine healthy volunteers and nine heartburn patients underwent two 2-h studies of combined MII/pH in right lateral decubitus after a refluxogenic meal in random order: on placebo and after baclofen 40 mg p.o. Tracings were analysed for acid and non-acid reflux episodes, re-reflux and symptoms in the heartburn patients.

RESULTS

In normal subjects baclofen significantly reduced the median number of episodes of acid (7 vs. 1, P = 0.02), non-acid (2 vs. 0, P = 0.005), and all reflux combined (10 vs. 2, P = 0.006); re-reflux was not reduced (0 vs. 0, P = N.S.). In heartburn patients, baclofen significantly decreased the median number of episodes of acid (15 vs. 6, P = 0.004), non-acid (4 vs. 2, P = 0.003), re-reflux (2 vs. 0, P = 0.02), and all reflux combined (23 vs. 8, P = 0.004); it also reduced the median number of acid-related (9 vs. 1, P = 0.008) and non-acid-related (1 vs. 0, P = 0.04) symptoms.

CONCLUSIONS

Baclofen reduces post-prandial acid and non-acid reflux and their associated symptoms. GABA B agonists may have a role in treating GERD.

Authors+Show Affiliations

Department of Medicine, Graduate Hospital, Philadelphia, PA, USA. velam@ccf.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12534409

Citation

Vela, M F., et al. "Baclofen Decreases Acid and Non-acid Post-prandial Gastro-oesophageal Reflux Measured By Combined Multichannel Intraluminal Impedance and PH." Alimentary Pharmacology & Therapeutics, vol. 17, no. 2, 2003, pp. 243-51.
Vela MF, Tutuian R, Katz PO, et al. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther. 2003;17(2):243-51.
Vela, M. F., Tutuian, R., Katz, P. O., & Castell, D. O. (2003). Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Alimentary Pharmacology & Therapeutics, 17(2), 243-51.
Vela MF, et al. Baclofen Decreases Acid and Non-acid Post-prandial Gastro-oesophageal Reflux Measured By Combined Multichannel Intraluminal Impedance and PH. Aliment Pharmacol Ther. 2003;17(2):243-51. PubMed PMID: 12534409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. AU - Vela,M F, AU - Tutuian,R, AU - Katz,P O, AU - Castell,D O, PY - 2003/1/22/pubmed PY - 2003/3/26/medline PY - 2003/1/22/entrez SP - 243 EP - 51 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 17 IS - 2 N2 - BACKGROUND: Omeprazole controls acid but not non-acid reflux. The GABA B agonist baclofen decreases acid reflux through the inhibition of transient lower oesophageal sphincter relaxations (TLESRs) and should similarly decrease non-acid reflux. Using combined multichannel intraluminal impedance and pH (MII/pH), we compared acid and non-acid reflux after placebo and baclofen. METHODS: Nine healthy volunteers and nine heartburn patients underwent two 2-h studies of combined MII/pH in right lateral decubitus after a refluxogenic meal in random order: on placebo and after baclofen 40 mg p.o. Tracings were analysed for acid and non-acid reflux episodes, re-reflux and symptoms in the heartburn patients. RESULTS: In normal subjects baclofen significantly reduced the median number of episodes of acid (7 vs. 1, P = 0.02), non-acid (2 vs. 0, P = 0.005), and all reflux combined (10 vs. 2, P = 0.006); re-reflux was not reduced (0 vs. 0, P = N.S.). In heartburn patients, baclofen significantly decreased the median number of episodes of acid (15 vs. 6, P = 0.004), non-acid (4 vs. 2, P = 0.003), re-reflux (2 vs. 0, P = 0.02), and all reflux combined (23 vs. 8, P = 0.004); it also reduced the median number of acid-related (9 vs. 1, P = 0.008) and non-acid-related (1 vs. 0, P = 0.04) symptoms. CONCLUSIONS: Baclofen reduces post-prandial acid and non-acid reflux and their associated symptoms. GABA B agonists may have a role in treating GERD. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/12534409/Baclofen_decreases_acid_and_non_acid_post_prandial_gastro_oesophageal_reflux_measured_by_combined_multichannel_intraluminal_impedance_and_pH_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2003&volume=17&issue=2&spage=243 DB - PRIME DP - Unbound Medicine ER -