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125-I-labeled fibrinogen scanning. Use in the diagnosis of venous thrombosis.
JAMA. 1975 Sep 01; 233(9):970-3.JAMA

Abstract

Venous thrombosis is often asymptomatic in patients in whom major pulmonary embolism develops. When used expectantly, iodine 125-labeled fibrinogen scanning is a very sensitive method for detecting subclinical leg vein thrombi. Fibrinogen scanning is less useful for the diagnosis of established venous thrombosis, but is valuable for detecting extension of venographically diagnosed calf vein thrombosis. The technique is safe if fibrinogen is obtained from carefully screened donors. The limitations of the method include its inability to distinguish between superficial and deep venous thrombi, and its sensitivity to fibrin in hematoma and inflammatory exudates. Though the results agree closely with those of phlebography, scanning seems less reliable for detecting femoral vein than calf vein thrombi and is insensitive to thrombi above the inguinal ligament. Screening for these major thrombi may be improved by combining fibrinogen scanning with impedance plethysmography or ultrasonic examination.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

125351

Citation

Hirsh, J, and A S. Gallus. "125-I-labeled Fibrinogen Scanning. Use in the Diagnosis of Venous Thrombosis." JAMA, vol. 233, no. 9, 1975, pp. 970-3.
Hirsh J, Gallus AS. 125-I-labeled fibrinogen scanning. Use in the diagnosis of venous thrombosis. JAMA. 1975;233(9):970-3.
Hirsh, J., & Gallus, A. S. (1975). 125-I-labeled fibrinogen scanning. Use in the diagnosis of venous thrombosis. JAMA, 233(9), 970-3.
Hirsh J, Gallus AS. 125-I-labeled Fibrinogen Scanning. Use in the Diagnosis of Venous Thrombosis. JAMA. 1975 Sep 1;233(9):970-3. PubMed PMID: 125351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 125-I-labeled fibrinogen scanning. Use in the diagnosis of venous thrombosis. AU - Hirsh,J, AU - Gallus,A S, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 970 EP - 3 JF - JAMA JO - JAMA VL - 233 IS - 9 N2 - Venous thrombosis is often asymptomatic in patients in whom major pulmonary embolism develops. When used expectantly, iodine 125-labeled fibrinogen scanning is a very sensitive method for detecting subclinical leg vein thrombi. Fibrinogen scanning is less useful for the diagnosis of established venous thrombosis, but is valuable for detecting extension of venographically diagnosed calf vein thrombosis. The technique is safe if fibrinogen is obtained from carefully screened donors. The limitations of the method include its inability to distinguish between superficial and deep venous thrombi, and its sensitivity to fibrin in hematoma and inflammatory exudates. Though the results agree closely with those of phlebography, scanning seems less reliable for detecting femoral vein than calf vein thrombi and is insensitive to thrombi above the inguinal ligament. Screening for these major thrombi may be improved by combining fibrinogen scanning with impedance plethysmography or ultrasonic examination. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/125351/125_I_labeled_fibrinogen_scanning__Use_in_the_diagnosis_of_venous_thrombosis_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/233/pg/970 DB - PRIME DP - Unbound Medicine ER -