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Hemodilution is common in patients with advanced heart failure.
Circulation. 2003 Jan 21; 107(2):226-9.Circ

Abstract

BACKGROUND

Anemia frequently occurs in chronic heart failure (CHF) patients and is associated with a poor prognosis. A low hematocrit may result from an increased plasma volume (hemodilution) or from reduced red blood cell volume (true anemia). The prevalence and clinical outcome of CHF patients with hemodilution is unknown.

METHODS AND RESULTS

The prevalence of anemia and its effect on outcome was examined in 196 patients with CHF. The prevalence of hemodilution was assessed in a subset of 37 ambulatory anemic patients with I131-tagged albumin to measure red blood cell and plasma volume. Clinical outcome was monitored. Sixty-one percent of the CHF patients were anemic. The prevalence of anemia increased from 33% in patients with New York Heart Association class II heart failure to 68% in class IV CHF patients. Survival was reduced in anemic patients compared with patients with a normal hematocrit (P<0.05). In the subset of 37 anemic patients, 17 patients (46%) had hemodilution and 20 patients (54%) had a true anemia. Nine patients with hemodilution died or underwent urgent transplant compared with 4 patients in the true anemia group (P<0.04).

CONCLUSION

Hemodilution is common in CHF patients. Anemia is associated with a poor prognosis in CHF. Patients with hemodilution tend to do worse than patients with true anemia, which suggests that volume overload may be an important mechanism contributing to the poor outcome in anemic CHF patients.

Authors+Show Affiliations

Department of Medicine, Columbia University, New York, NY, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12538419

Citation

Androne, Ana-Silvia, et al. "Hemodilution Is Common in Patients With Advanced Heart Failure." Circulation, vol. 107, no. 2, 2003, pp. 226-9.
Androne AS, Katz SD, Lund L, et al. Hemodilution is common in patients with advanced heart failure. Circulation. 2003;107(2):226-9.
Androne, A. S., Katz, S. D., Lund, L., LaManca, J., Hudaihed, A., Hryniewicz, K., & Mancini, D. M. (2003). Hemodilution is common in patients with advanced heart failure. Circulation, 107(2), 226-9.
Androne AS, et al. Hemodilution Is Common in Patients With Advanced Heart Failure. Circulation. 2003 Jan 21;107(2):226-9. PubMed PMID: 12538419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemodilution is common in patients with advanced heart failure. AU - Androne,Ana-Silvia, AU - Katz,Stuart D, AU - Lund,Lars, AU - LaManca,John, AU - Hudaihed,Alhakam, AU - Hryniewicz,Katarzyna, AU - Mancini,Donna M, PY - 2003/1/23/pubmed PY - 2003/1/29/medline PY - 2003/1/23/entrez SP - 226 EP - 9 JF - Circulation JO - Circulation VL - 107 IS - 2 N2 - BACKGROUND: Anemia frequently occurs in chronic heart failure (CHF) patients and is associated with a poor prognosis. A low hematocrit may result from an increased plasma volume (hemodilution) or from reduced red blood cell volume (true anemia). The prevalence and clinical outcome of CHF patients with hemodilution is unknown. METHODS AND RESULTS: The prevalence of anemia and its effect on outcome was examined in 196 patients with CHF. The prevalence of hemodilution was assessed in a subset of 37 ambulatory anemic patients with I131-tagged albumin to measure red blood cell and plasma volume. Clinical outcome was monitored. Sixty-one percent of the CHF patients were anemic. The prevalence of anemia increased from 33% in patients with New York Heart Association class II heart failure to 68% in class IV CHF patients. Survival was reduced in anemic patients compared with patients with a normal hematocrit (P<0.05). In the subset of 37 anemic patients, 17 patients (46%) had hemodilution and 20 patients (54%) had a true anemia. Nine patients with hemodilution died or underwent urgent transplant compared with 4 patients in the true anemia group (P<0.04). CONCLUSION: Hemodilution is common in CHF patients. Anemia is associated with a poor prognosis in CHF. Patients with hemodilution tend to do worse than patients with true anemia, which suggests that volume overload may be an important mechanism contributing to the poor outcome in anemic CHF patients. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/12538419/Hemodilution_is_common_in_patients_with_advanced_heart_failure_ L2 - https://www.ahajournals.org/doi/10.1161/01.cir.0000052623.16194.80?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -