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Evaluation of the immunochromatographic Binax NOW assay for detection of Streptococcus pneumoniae urinary antigen in a prospective study of community-acquired pneumonia in Spain.
Clin Infect Dis. 2003 Feb 01; 36(3):286-92.CI

Abstract

We evaluated the Binax NOW rapid immunochromatographic membrane test (ICT) for detection of Streptococcus pneumoniae urinary antigen in a population-based prospective study of adults with community-acquired pneumonia (CAP). ICT was performed with urine samples obtained from 452 (91.7%) of 493 patients enrolled. Pneumococcal antigen was detected in 19 (70.4%) of 27 patients with pneumococcal pneumonia. The test results were more frequently positive for patients who had not received antibiotics before testing (26.6% vs. 12.1%; P=.002). Only 16 (10.3%) of 156 samples obtained from patients with nonpneumococcal pneumonia yielded a positive result. Of the 269 patients who had pneumonia with no pathogen identified, antigen was detected in 69 (25.7%). With conventional microbiological criteria used as the "gold standard," the test had a sensitivity of 70.4% and a specificity of 89.7%. Testing concentrated urine samples with the ICT may be a useful technique for rapid diagnosis of pneumococcal pneumonia in adults with CAP.

Authors+Show Affiliations

Infectious Diseases Unit, Internal Medicine Department, Hospital General Universitario de Elche, Alicante, Spain. gutierrez_fel@gva.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

12539069

Citation

Gutiérrez, Félix, et al. "Evaluation of the Immunochromatographic Binax NOW Assay for Detection of Streptococcus Pneumoniae Urinary Antigen in a Prospective Study of Community-acquired Pneumonia in Spain." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 36, no. 3, 2003, pp. 286-92.
Gutiérrez F, Masiá M, Rodríguez JC, et al. Evaluation of the immunochromatographic Binax NOW assay for detection of Streptococcus pneumoniae urinary antigen in a prospective study of community-acquired pneumonia in Spain. Clin Infect Dis. 2003;36(3):286-92.
Gutiérrez, F., Masiá, M., Rodríguez, J. C., Ayelo, A., Soldán, B., Cebrián, L., Mirete, C., Royo, G., & Hidalgo, A. M. (2003). Evaluation of the immunochromatographic Binax NOW assay for detection of Streptococcus pneumoniae urinary antigen in a prospective study of community-acquired pneumonia in Spain. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 36(3), 286-92.
Gutiérrez F, et al. Evaluation of the Immunochromatographic Binax NOW Assay for Detection of Streptococcus Pneumoniae Urinary Antigen in a Prospective Study of Community-acquired Pneumonia in Spain. Clin Infect Dis. 2003 Feb 1;36(3):286-92. PubMed PMID: 12539069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the immunochromatographic Binax NOW assay for detection of Streptococcus pneumoniae urinary antigen in a prospective study of community-acquired pneumonia in Spain. AU - Gutiérrez,Félix, AU - Masiá,Mar, AU - Rodríguez,J Carlos, AU - Ayelo,Antonio, AU - Soldán,Bernardo, AU - Cebrián,Laura, AU - Mirete,Carlos, AU - Royo,Gloria, AU - Hidalgo,Alberto M, Y1 - 2003/01/15/ PY - 2002/06/27/received PY - 2002/10/21/revised PY - 2003/1/23/pubmed PY - 2003/2/8/medline PY - 2003/1/23/entrez SP - 286 EP - 92 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 36 IS - 3 N2 - We evaluated the Binax NOW rapid immunochromatographic membrane test (ICT) for detection of Streptococcus pneumoniae urinary antigen in a population-based prospective study of adults with community-acquired pneumonia (CAP). ICT was performed with urine samples obtained from 452 (91.7%) of 493 patients enrolled. Pneumococcal antigen was detected in 19 (70.4%) of 27 patients with pneumococcal pneumonia. The test results were more frequently positive for patients who had not received antibiotics before testing (26.6% vs. 12.1%; P=.002). Only 16 (10.3%) of 156 samples obtained from patients with nonpneumococcal pneumonia yielded a positive result. Of the 269 patients who had pneumonia with no pathogen identified, antigen was detected in 69 (25.7%). With conventional microbiological criteria used as the "gold standard," the test had a sensitivity of 70.4% and a specificity of 89.7%. Testing concentrated urine samples with the ICT may be a useful technique for rapid diagnosis of pneumococcal pneumonia in adults with CAP. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/12539069/Evaluation_of_the_immunochromatographic_Binax_NOW_assay_for_detection_of_Streptococcus_pneumoniae_urinary_antigen_in_a_prospective_study_of_community_acquired_pneumonia_in_Spain_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/345852 DB - PRIME DP - Unbound Medicine ER -