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A prospective study of intake of fish and marine fatty acids and prostate cancer.
Cancer Epidemiol Biomarkers Prev. 2003 Jan; 12(1):64-7.CE

Abstract

Experimental studies suggest that marine fatty acids have an antitumor effect on prostate tumor cells. The aim of this study was to investigate whether high consumption of fish and marine fatty acids reduces the risk of prostate cancer in humans. We followed 47882 men participating in the Health Professionals Follow-up Study. Dietary intake was assessed in 1986, 1990, and 1994, using a validated food frequency questionnaire. During 12 years of follow-up, 2482 cases of prostate cancer were diagnosed, of which 617 were diagnosed as advanced prostate cancer including 278 metastatic prostate cancers. Eating fish more than three times per week was associated with a reduced risk of prostate cancer, and the strongest association was for metastatic cancer (multivariate relative risk, 0.56; 95% confidence interval, 0.37-0.86, compared with infrequent consumption, i.e., less than twice per month). Intake of marine fatty acids from food showed a similar but weaker association. Each additional daily intake of 0.5 g of marine fatty acid from food was associated with a 24% decreased risk of metastatic cancer. We found that men with high consumption of fish had a lower risk of prostate cancer, especially for metastatic cancer. Marine fatty acids may account for part of the effect, but other factors in fish may also play a role.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts, USA. katarina.augustsson@mep.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12540506

Citation

Augustsson, Katarina, et al. "A Prospective Study of Intake of Fish and Marine Fatty Acids and Prostate Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 1, 2003, pp. 64-7.
Augustsson K, Michaud DS, Rimm EB, et al. A prospective study of intake of fish and marine fatty acids and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2003;12(1):64-7.
Augustsson, K., Michaud, D. S., Rimm, E. B., Leitzmann, M. F., Stampfer, M. J., Willett, W. C., & Giovannucci, E. (2003). A prospective study of intake of fish and marine fatty acids and prostate cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(1), 64-7.
Augustsson K, et al. A Prospective Study of Intake of Fish and Marine Fatty Acids and Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2003;12(1):64-7. PubMed PMID: 12540506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of intake of fish and marine fatty acids and prostate cancer. AU - Augustsson,Katarina, AU - Michaud,Dominique S, AU - Rimm,Eric B, AU - Leitzmann,Michael F, AU - Stampfer,Meir J, AU - Willett,Walter C, AU - Giovannucci,Edward, PY - 2003/1/24/pubmed PY - 2003/5/13/medline PY - 2003/1/24/entrez SP - 64 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 12 IS - 1 N2 - Experimental studies suggest that marine fatty acids have an antitumor effect on prostate tumor cells. The aim of this study was to investigate whether high consumption of fish and marine fatty acids reduces the risk of prostate cancer in humans. We followed 47882 men participating in the Health Professionals Follow-up Study. Dietary intake was assessed in 1986, 1990, and 1994, using a validated food frequency questionnaire. During 12 years of follow-up, 2482 cases of prostate cancer were diagnosed, of which 617 were diagnosed as advanced prostate cancer including 278 metastatic prostate cancers. Eating fish more than three times per week was associated with a reduced risk of prostate cancer, and the strongest association was for metastatic cancer (multivariate relative risk, 0.56; 95% confidence interval, 0.37-0.86, compared with infrequent consumption, i.e., less than twice per month). Intake of marine fatty acids from food showed a similar but weaker association. Each additional daily intake of 0.5 g of marine fatty acid from food was associated with a 24% decreased risk of metastatic cancer. We found that men with high consumption of fish had a lower risk of prostate cancer, especially for metastatic cancer. Marine fatty acids may account for part of the effect, but other factors in fish may also play a role. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12540506/A_prospective_study_of_intake_of_fish_and_marine_fatty_acids_and_prostate_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12540506 DB - PRIME DP - Unbound Medicine ER -