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Psychosocial risk factors for heart disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME).
Int J Epidemiol 2002; 31(6):1227-34IJ

Abstract

BACKGROUND

France has a substantially lower level of premature mortality from cardiovascular diseases (CVD) relative to its comparators. Compared with Northern Ireland, France has one-half the rate, despite having a similar cardiovascular risk profile to Northern Ireland. In this prospective longitudinal study the psychosocial risk hypothesis for CVD was tested.

METHOD

A cohort of 9758 men (7359 in France and 2399 in Northern Ireland) aged 50-59 years who were initially free of any CVD were recruited. At baseline the subjects completed a psychosocial questionnaire, measuring hostility, depression, social support, and the Type A behaviour pattern. At 5-years follow-up their clinical status was determined.

RESULTS

Multivariate analysis indicated that, contrary to prediction, France had a substantially more negative psychosocial risk profile than Northern Ireland. The psychosocial risk factors were not successful at predicting at 5-years follow-up the hard clinical endpoint of definite fatal/non-fatal myocardial infarction. In the case of the softer clinical endpoint, angina pectoris/unstable angina, only depression predicted outcome with a small effect size.

CONCLUSION

The findings provide little support for the psychosocial risk hypothesis. The psychosocial risk profile was more negative in France, the opposite of that predicted. The finding of a relationship between depression and angina may reflect a tendency for individuals who respond negatively on mood state to report more cardiac symptoms irrespective of physical disease state.

Authors+Show Affiliations

School of Psychology, Department of Epidemiology and Public Health, Queen's University, Belfast BT7 1NN, Northern Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

12540727

Citation

Sykes, D H., et al. "Psychosocial Risk Factors for Heart Disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME)." International Journal of Epidemiology, vol. 31, no. 6, 2002, pp. 1227-34.
Sykes D, Arveiler D, Salters CP, et al. Psychosocial risk factors for heart disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Int J Epidemiol. 2002;31(6):1227-34.
Sykes, D., Arveiler, D., Salters, C. P., Ferrieres, J., McCrum, E., Amouyel, P., ... Evans, A. E. (2002). Psychosocial risk factors for heart disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). International Journal of Epidemiology, 31(6), pp. 1227-34.
Sykes D, et al. Psychosocial Risk Factors for Heart Disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Int J Epidemiol. 2002;31(6):1227-34. PubMed PMID: 12540727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychosocial risk factors for heart disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). AU - Sykes,D H, AU - Arveiler,D, AU - Salters,C P, AU - Ferrieres,J, AU - McCrum,E, AU - Amouyel,P, AU - Bingham,A, AU - Montaye,M, AU - Ruidavets,J-B, AU - Haas,B, AU - Ducimetiere,P, AU - Evans,A E, PY - 2003/1/24/pubmed PY - 2003/5/21/medline PY - 2003/1/24/entrez SP - 1227 EP - 34 JF - International journal of epidemiology JO - Int J Epidemiol VL - 31 IS - 6 N2 - BACKGROUND: France has a substantially lower level of premature mortality from cardiovascular diseases (CVD) relative to its comparators. Compared with Northern Ireland, France has one-half the rate, despite having a similar cardiovascular risk profile to Northern Ireland. In this prospective longitudinal study the psychosocial risk hypothesis for CVD was tested. METHOD: A cohort of 9758 men (7359 in France and 2399 in Northern Ireland) aged 50-59 years who were initially free of any CVD were recruited. At baseline the subjects completed a psychosocial questionnaire, measuring hostility, depression, social support, and the Type A behaviour pattern. At 5-years follow-up their clinical status was determined. RESULTS: Multivariate analysis indicated that, contrary to prediction, France had a substantially more negative psychosocial risk profile than Northern Ireland. The psychosocial risk factors were not successful at predicting at 5-years follow-up the hard clinical endpoint of definite fatal/non-fatal myocardial infarction. In the case of the softer clinical endpoint, angina pectoris/unstable angina, only depression predicted outcome with a small effect size. CONCLUSION: The findings provide little support for the psychosocial risk hypothesis. The psychosocial risk profile was more negative in France, the opposite of that predicted. The finding of a relationship between depression and angina may reflect a tendency for individuals who respond negatively on mood state to report more cardiac symptoms irrespective of physical disease state. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/12540727/Psychosocial_risk_factors_for_heart_disease_in_France_and_Northern_Ireland:_the_Prospective_Epidemiological_Study_of_Myocardial_Infarction__PRIME__ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/31.6.1227 DB - PRIME DP - Unbound Medicine ER -