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[Breast calcifications with percutaneous vacuum-assisted biopsy diagnosis of malignancy or atypical hyerplasia: correlations with surgical findings].
Pathologica. 2002 Dec; 94(6):299-305.P

Abstract

Percutaneous, stereotactic, vacuum-assisted biopsy has become a widely used alternative to open surgical biopsy for the initial diagnosis of breast calcifications. We retrospectively assessed the accuracy of the technique in the diagnoses of malignancy and atypical hyperplasia by correlation with the findings of the subsequent surgical excision. We studied 330 consecutive cases of breast calcifications, 216 (65.5%) of which were determined to be benign and 114 (34.5%) to be malignant or atypical at vacuum-assisted biopsy using an 11 gauge instrument. Of the latter 93 were available for comparison with the subsequent surgery, the specific diagnoses as revealed by percutaneous biopsy were as follows: 11 cases of atypical ductal hyperplasia (ADN), 67 cases of ductal carcinoma in situ (DCIS), 6 infiltrating ductal carcinomas (IFDC), 2 cases of atypical lobular hyperplasia and 7 of lobular carcinoma in situ (LCIS). At histological analysis after surgical excision, 3 (27%) of 11 cases previously diagnosed as ADH and 6 (9%) of 67 cases diagnosed as DCIS were shown to actually be higher grade lesions (DCIS/IFDC and IFDC, respectively). Of the 7 lesions diagnosed at vacuum-assisted biopsy as LCIS, surgery and histological analysis showed one infiltrating globular carcinoma and two DCIS. A total of 21 lesions (4 ADH, 14 DCIS, 1 IFDC, 2 LCIS) were completely removed at percutaneous biopsy; the remaining cases were found totally concordant. These data Indicate a substantial accuracy of the percutaneous biopsy: some lesions (particularly those thought to be ADH and DCIS) can be underestimated for sampling error.

Authors+Show Affiliations

Servizio di Anatomia Patologica, Ospedale Civile Maggiore, Azienda Ospedaliera di Verona, Piazzale Stefani 1, I-37126 Verona, Italia. Quirino.Piubello@mail.azosp.vr.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Validation Study

Language

ita

PubMed ID

12540993

Citation

Piubello, Q, et al. "[Breast Calcifications With Percutaneous Vacuum-assisted Biopsy Diagnosis of Malignancy or Atypical Hyerplasia: Correlations With Surgical Findings]." Pathologica, vol. 94, no. 6, 2002, pp. 299-305.
Piubello Q, Montemezzi S, D'Atri C. [Breast calcifications with percutaneous vacuum-assisted biopsy diagnosis of malignancy or atypical hyerplasia: correlations with surgical findings]. Pathologica. 2002;94(6):299-305.
Piubello, Q., Montemezzi, S., & D'Atri, C. (2002). [Breast calcifications with percutaneous vacuum-assisted biopsy diagnosis of malignancy or atypical hyerplasia: correlations with surgical findings]. Pathologica, 94(6), 299-305.
Piubello Q, Montemezzi S, D'Atri C. [Breast Calcifications With Percutaneous Vacuum-assisted Biopsy Diagnosis of Malignancy or Atypical Hyerplasia: Correlations With Surgical Findings]. Pathologica. 2002;94(6):299-305. PubMed PMID: 12540993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Breast calcifications with percutaneous vacuum-assisted biopsy diagnosis of malignancy or atypical hyerplasia: correlations with surgical findings]. AU - Piubello,Q, AU - Montemezzi,S, AU - D'Atri,C, PY - 2003/1/24/pubmed PY - 2003/4/8/medline PY - 2003/1/24/entrez SP - 299 EP - 305 JF - Pathologica JO - Pathologica VL - 94 IS - 6 N2 - Percutaneous, stereotactic, vacuum-assisted biopsy has become a widely used alternative to open surgical biopsy for the initial diagnosis of breast calcifications. We retrospectively assessed the accuracy of the technique in the diagnoses of malignancy and atypical hyperplasia by correlation with the findings of the subsequent surgical excision. We studied 330 consecutive cases of breast calcifications, 216 (65.5%) of which were determined to be benign and 114 (34.5%) to be malignant or atypical at vacuum-assisted biopsy using an 11 gauge instrument. Of the latter 93 were available for comparison with the subsequent surgery, the specific diagnoses as revealed by percutaneous biopsy were as follows: 11 cases of atypical ductal hyperplasia (ADN), 67 cases of ductal carcinoma in situ (DCIS), 6 infiltrating ductal carcinomas (IFDC), 2 cases of atypical lobular hyperplasia and 7 of lobular carcinoma in situ (LCIS). At histological analysis after surgical excision, 3 (27%) of 11 cases previously diagnosed as ADH and 6 (9%) of 67 cases diagnosed as DCIS were shown to actually be higher grade lesions (DCIS/IFDC and IFDC, respectively). Of the 7 lesions diagnosed at vacuum-assisted biopsy as LCIS, surgery and histological analysis showed one infiltrating globular carcinoma and two DCIS. A total of 21 lesions (4 ADH, 14 DCIS, 1 IFDC, 2 LCIS) were completely removed at percutaneous biopsy; the remaining cases were found totally concordant. These data Indicate a substantial accuracy of the percutaneous biopsy: some lesions (particularly those thought to be ADH and DCIS) can be underestimated for sampling error. SN - 0031-2983 UR - https://www.unboundmedicine.com/medline/citation/12540993/[Breast_calcifications_with_percutaneous_vacuum_assisted_biopsy_diagnosis_of_malignancy_or_atypical_hyerplasia:_correlations_with_surgical_findings]_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -