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Influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers.
Am J Ind Med 2003; 43(2):165-71AJ

Abstract

BACKGROUND

The relationship between delta-aminolevulinic acid dehydratase polymorphism (ALAD) and biomarkers of exposure was investigated in Turkish lead workers in this study.

METHODS

Seventy two male lead battery manufacturing workers were selected for the study. Blood lead (BPb) and urinary lead (UPb) concentrations were determined by atomic absorption spectrometry. Erythrocyte ALAD activity and urinary 5-aminolevulinic acid (UALA) were measured spectrophotometrically. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the genotype of the ALAD gene.

RESULTS

In total, 51 workers (70.8%) had the ALAD 1-1 genotype, whereas 21 workers (29.2%) had the ALAD 1-2 genotype. No significant relationships were found between the two genotypes and BPb, UPb, and ALAD activity. ALAD1 homozygotes showed significantly higher levels of UALA in comparison with those ALAD2 carriers.

CONCLUSIONS

ALAD 1-1 individuals might be an increased risk compared to ALAD2 carriers to disturbance in heme biosynthetic pathway in high lead exposure.

Authors+Show Affiliations

Department of Toxicology, Faculty of Pharmacy, Ankara University, Ankara, Turkey. suzen@pharmacy.ankara.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12541271

Citation

Süzen, H Sinan, et al. "Influence of the Delta-aminolevulinic Acid Dehydratase (ALAD) Polymorphism On Biomarkers of Lead Exposure in Turkish Storage Battery Manufacturing Workers." American Journal of Industrial Medicine, vol. 43, no. 2, 2003, pp. 165-71.
Süzen HS, Duydu Y, Aydin A, et al. Influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers. Am J Ind Med. 2003;43(2):165-71.
Süzen, H. S., Duydu, Y., Aydin, A., Işimer, A., & Vural, N. (2003). Influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers. American Journal of Industrial Medicine, 43(2), pp. 165-71.
Süzen HS, et al. Influence of the Delta-aminolevulinic Acid Dehydratase (ALAD) Polymorphism On Biomarkers of Lead Exposure in Turkish Storage Battery Manufacturing Workers. Am J Ind Med. 2003;43(2):165-71. PubMed PMID: 12541271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers. AU - Süzen,H Sinan, AU - Duydu,Yalçin, AU - Aydin,Ahmet, AU - Işimer,Aşkin, AU - Vural,Nevin, PY - 2003/1/24/pubmed PY - 2003/5/23/medline PY - 2003/1/24/entrez SP - 165 EP - 71 JF - American journal of industrial medicine JO - Am. J. Ind. Med. VL - 43 IS - 2 N2 - BACKGROUND: The relationship between delta-aminolevulinic acid dehydratase polymorphism (ALAD) and biomarkers of exposure was investigated in Turkish lead workers in this study. METHODS: Seventy two male lead battery manufacturing workers were selected for the study. Blood lead (BPb) and urinary lead (UPb) concentrations were determined by atomic absorption spectrometry. Erythrocyte ALAD activity and urinary 5-aminolevulinic acid (UALA) were measured spectrophotometrically. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the genotype of the ALAD gene. RESULTS: In total, 51 workers (70.8%) had the ALAD 1-1 genotype, whereas 21 workers (29.2%) had the ALAD 1-2 genotype. No significant relationships were found between the two genotypes and BPb, UPb, and ALAD activity. ALAD1 homozygotes showed significantly higher levels of UALA in comparison with those ALAD2 carriers. CONCLUSIONS: ALAD 1-1 individuals might be an increased risk compared to ALAD2 carriers to disturbance in heme biosynthetic pathway in high lead exposure. SN - 0271-3586 UR - https://www.unboundmedicine.com/medline/citation/12541271/Influence_of_the_delta_aminolevulinic_acid_dehydratase__ALAD__polymorphism_on_biomarkers_of_lead_exposure_in_Turkish_storage_battery_manufacturing_workers_ L2 - https://doi.org/10.1002/ajim.10158 DB - PRIME DP - Unbound Medicine ER -