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Lifetime principal occupation and risk of Alzheimer's disease in the Kungsholmen project.
Am J Ind Med. 2003 Feb; 43(2):204-11.AJ

Abstract

BACKGROUND

Some studies suggest that manual work is associated with dementia. This study is aimed at identifying the specific occupational categories that may be related to dementia.

METHODS

A cohort of 913 non-demented subjects aged 75 + years was longitudinally examined twice over 6 years to detect incident dementia using the DSM-III-R diagnostic criteria. The lifetime longest occupations of all subjects were divided into different categories according to the occupation-based classification system. Data were analyzed with Cox models.

RESULTS

During the follow-up period, 260 subjects were diagnosed with dementia (197 with Alzheimer's disease). Manual work was associated with an increased risk of dementia, and the association was dependent on educational level. Compared with non-manual work, manual work involving goods production had a multi-adjusted relative risk (95% CI) of 1.6 (1.0-2.5, P = 0.046) for Alzheimer's disease and 1.4 (0.9-2.1) for dementia.

CONCLUSIONS

An association between goods production, manual work and Alzheimer's disease found in this study suggests that factors in the mid-twentieth century goods production environment may be involved in the development of Alzheimer's disease.

Authors+Show Affiliations

Qiu C
Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and the Stockholm Gerontology Research Center, Sweden. chengxuan.qui@neurotec.ki.se
Karp A
No affiliation info available
von Strauss E
No affiliation info available
Winblad B
No affiliation info available
Fratiglioni L
No affiliation info available
Bellander T
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseCohort StudiesConfidence IntervalsDementiaEducational StatusFemaleHumansIncidenceLogistic ModelsLongitudinal StudiesMaleOccupationsOdds RatioProportional Hazards ModelsRegression AnalysisRetrospective StudiesRisk AssessmentSex FactorsSurveys and QuestionnairesSweden

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12541276

Citation

Qiu, Chengxuan, et al. "Lifetime Principal Occupation and Risk of Alzheimer's Disease in the Kungsholmen Project." American Journal of Industrial Medicine, vol. 43, no. 2, 2003, pp. 204-11.
Qiu C, Karp A, von Strauss E, et al. Lifetime principal occupation and risk of Alzheimer's disease in the Kungsholmen project. Am J Ind Med. 2003;43(2):204-11.
Qiu, C., Karp, A., von Strauss, E., Winblad, B., Fratiglioni, L., & Bellander, T. (2003). Lifetime principal occupation and risk of Alzheimer's disease in the Kungsholmen project. American Journal of Industrial Medicine, 43(2), 204-11.
Qiu C, et al. Lifetime Principal Occupation and Risk of Alzheimer's Disease in the Kungsholmen Project. Am J Ind Med. 2003;43(2):204-11. PubMed PMID: 12541276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifetime principal occupation and risk of Alzheimer's disease in the Kungsholmen project. AU - Qiu,Chengxuan, AU - Karp,Anita, AU - von Strauss,Eva, AU - Winblad,Bengt, AU - Fratiglioni,Laura, AU - Bellander,Tom, PY - 2003/1/24/pubmed PY - 2003/5/23/medline PY - 2003/1/24/entrez SP - 204 EP - 11 JF - American journal of industrial medicine JO - Am J Ind Med VL - 43 IS - 2 N2 - BACKGROUND: Some studies suggest that manual work is associated with dementia. This study is aimed at identifying the specific occupational categories that may be related to dementia. METHODS: A cohort of 913 non-demented subjects aged 75 + years was longitudinally examined twice over 6 years to detect incident dementia using the DSM-III-R diagnostic criteria. The lifetime longest occupations of all subjects were divided into different categories according to the occupation-based classification system. Data were analyzed with Cox models. RESULTS: During the follow-up period, 260 subjects were diagnosed with dementia (197 with Alzheimer's disease). Manual work was associated with an increased risk of dementia, and the association was dependent on educational level. Compared with non-manual work, manual work involving goods production had a multi-adjusted relative risk (95% CI) of 1.6 (1.0-2.5, P = 0.046) for Alzheimer's disease and 1.4 (0.9-2.1) for dementia. CONCLUSIONS: An association between goods production, manual work and Alzheimer's disease found in this study suggests that factors in the mid-twentieth century goods production environment may be involved in the development of Alzheimer's disease. SN - 0271-3586 UR - https://www.unboundmedicine.com/medline/citation/12541276/Lifetime_principal_occupation_and_risk_of_Alzheimer's_disease_in_the_Kungsholmen_project_ DB - PRIME DP - Unbound Medicine ER -