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Presence of platelet-activating factor in nasal polyps and eosinophils.
Acta Otolaryngol. 2002 Dec; 122(8):872-6.AO

Abstract

Platelet-activating factor (PAF) has been reported to play a role in allergy and inflammatory reactions but its role in the pathogenesis of nasal polyps remains unclear. In this study, we examined both PAF and peptide leukotrienes (peptLTs) in individual preparations from nasal polyps. The amounts of PAF were much greater than those of peptLTs in all preparations. Nasal polyps were divided into two groups according to the severity of eosinophil infiltration: a severe group (eosinophil count > or = 50/mm2) and a mild group (eosinophil count < 50/mm2). The amounts of PAF in the nasal polyps were significantly higher in the severe group than in the mild group (p < 0.01). PAF activity correlated with tissue eosinophilia and polyps obtained from patients with aspirin-sensitive asthma contained relatively large amounts of PAF, with enriched infiltration of eosinophils.

Authors+Show Affiliations

Furukawa M
Department of Otolaryngology, Kansai Medical University, Osaka, Japan. furukawam@uasy6.com
Ogura M
No affiliation info available
Tsutsumi T
No affiliation info available
Tsuji H
No affiliation info available
Yamashita T
No affiliation info available

MeSH

AspirinAsthmaChromatography, Thin LayerDrug HypersensitivityEosinophilsHumansLeukocyte CountLeukotrienesNasal MucosaNasal PolypsPlatelet Activating FactorRadioimmunoassay

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12542208

Citation

Furukawa, Masayuki, et al. "Presence of Platelet-activating Factor in Nasal Polyps and Eosinophils." Acta Oto-laryngologica, vol. 122, no. 8, 2002, pp. 872-6.
Furukawa M, Ogura M, Tsutsumi T, et al. Presence of platelet-activating factor in nasal polyps and eosinophils. Acta Otolaryngol. 2002;122(8):872-6.
Furukawa, M., Ogura, M., Tsutsumi, T., Tsuji, H., & Yamashita, T. (2002). Presence of platelet-activating factor in nasal polyps and eosinophils. Acta Oto-laryngologica, 122(8), 872-6.
Furukawa M, et al. Presence of Platelet-activating Factor in Nasal Polyps and Eosinophils. Acta Otolaryngol. 2002;122(8):872-6. PubMed PMID: 12542208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presence of platelet-activating factor in nasal polyps and eosinophils. AU - Furukawa,Masayuki, AU - Ogura,Manabu, AU - Tsutsumi,Toshiyuki, AU - Tsuji,Hiroyuki, AU - Yamashita,Toshio, PY - 2003/1/25/pubmed PY - 2003/4/11/medline PY - 2003/1/25/entrez SP - 872 EP - 6 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 122 IS - 8 N2 - Platelet-activating factor (PAF) has been reported to play a role in allergy and inflammatory reactions but its role in the pathogenesis of nasal polyps remains unclear. In this study, we examined both PAF and peptide leukotrienes (peptLTs) in individual preparations from nasal polyps. The amounts of PAF were much greater than those of peptLTs in all preparations. Nasal polyps were divided into two groups according to the severity of eosinophil infiltration: a severe group (eosinophil count > or = 50/mm2) and a mild group (eosinophil count < 50/mm2). The amounts of PAF in the nasal polyps were significantly higher in the severe group than in the mild group (p < 0.01). PAF activity correlated with tissue eosinophilia and polyps obtained from patients with aspirin-sensitive asthma contained relatively large amounts of PAF, with enriched infiltration of eosinophils. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/12542208/Presence_of_platelet_activating_factor_in_nasal_polyps_and_eosinophils_ DB - PRIME DP - Unbound Medicine ER -