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New bioactive rosigenin analogues and aromatic polyketide metabolites from the freshwater aquatic fungus Massarina tunicata.
J Nat Prod. 2003 Jan; 66(1):73-9.JN

Abstract

Four new rosigenin analogues (massarigenins A-D; 1-4) and two new aromatic polyketide-derived secondary metabolites (massarinins A and B; 6, 7) and have been isolated from the freshwater aquatic fungus Massarina tunicata. The structures of these compounds were determined primarily by analysis of NMR data, and that of compound 1 was verified by X-ray crystallography. The known compound 4-(2-hydroxybutynoxy)benzoic acid (11) was also obtained, and its absolute stereochemistry was assigned. Several of these metabolites showed antibiotic activity against Gram-positive bacteria.

Authors+Show Affiliations

Oh H
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Swenson DC
No affiliation info available
Gloer JB
No affiliation info available
Shearer CA
No affiliation info available

MeSH

AscomycotaAspergillusBacillus subtilisCandida albicansCrystallography, X-RayFuransFusariumGram-Negative BacteriaModels, MolecularMolecular ConformationMolecular StructureNuclear Magnetic Resonance, BiomolecularSesquiterpenesSpiro CompoundsStaphylococcus aureusStereoisomerismWisconsin

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12542349

Citation

Oh, Hyuncheol, et al. "New Bioactive Rosigenin Analogues and Aromatic Polyketide Metabolites From the Freshwater Aquatic Fungus Massarina Tunicata." Journal of Natural Products, vol. 66, no. 1, 2003, pp. 73-9.
Oh H, Swenson DC, Gloer JB, et al. New bioactive rosigenin analogues and aromatic polyketide metabolites from the freshwater aquatic fungus Massarina tunicata. J Nat Prod. 2003;66(1):73-9.
Oh, H., Swenson, D. C., Gloer, J. B., & Shearer, C. A. (2003). New bioactive rosigenin analogues and aromatic polyketide metabolites from the freshwater aquatic fungus Massarina tunicata. Journal of Natural Products, 66(1), 73-9.
Oh H, et al. New Bioactive Rosigenin Analogues and Aromatic Polyketide Metabolites From the Freshwater Aquatic Fungus Massarina Tunicata. J Nat Prod. 2003;66(1):73-9. PubMed PMID: 12542349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New bioactive rosigenin analogues and aromatic polyketide metabolites from the freshwater aquatic fungus Massarina tunicata. AU - Oh,Hyuncheol, AU - Swenson,Dale C, AU - Gloer,James B, AU - Shearer,Carol A, PY - 2003/1/25/pubmed PY - 2003/6/21/medline PY - 2003/1/25/entrez SP - 73 EP - 9 JF - Journal of natural products JO - J Nat Prod VL - 66 IS - 1 N2 - Four new rosigenin analogues (massarigenins A-D; 1-4) and two new aromatic polyketide-derived secondary metabolites (massarinins A and B; 6, 7) and have been isolated from the freshwater aquatic fungus Massarina tunicata. The structures of these compounds were determined primarily by analysis of NMR data, and that of compound 1 was verified by X-ray crystallography. The known compound 4-(2-hydroxybutynoxy)benzoic acid (11) was also obtained, and its absolute stereochemistry was assigned. Several of these metabolites showed antibiotic activity against Gram-positive bacteria. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/12542349/New_bioactive_rosigenin_analogues_and_aromatic_polyketide_metabolites_from_the_freshwater_aquatic_fungus_Massarina_tunicata_ DB - PRIME DP - Unbound Medicine ER -