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Autoantibodies to malondialdehyde-modified low-density lipoprotein in patients with angiographically confirmed coronary artery disease.
J Pharm Pharmacol. 2002 Dec; 54(12):1651-7.JP

Abstract

Oxidised low-density lipoprotein (LDL) has physicochemical properties that are pivotal in atherosclerotic plaque formation. As a consequence, antioxidant regimens may prove an important therapy in the prevention and treatment of cardiovascular disease. Since oxidised LDL is immunogenic, the aims of our study were to measure serum IgG titres to malondialdehyde-modified LDL (MDA-LDL) in patients with coronary artery disease (CAD) and control subjects and assess their potential as a clinical marker for coronary atherosclerosis and, consequently, antioxidant intervention. Serum IgG titres to MDA-LDL were measured in patients with angiographically confirmed CAD (n = 40) and aged-matched controls (n = 40) by enzyme-linked immunosorbant assay (ELISA). Titres were calculated and expressed as both the difference and the ratio of blanked absorbance units (AU) for IgG binding to MDA-LDL and native LDL. For the control population, median IgG titres were 0.26 AU (interquartile range (IQR) 0.20-0.46 AU) and 5.34 (IQR 3.40-8.58), respectively, while the patient population had median IgG titres of 0.30 AU (IQR 0.20-0.47 AU) and 5.08 (IQR 3.30-9.66), respectively. Both sets of calculated titre values were not significantly different between the two groups (P = 0.60 and 0.82, respectively). In conclusion, this study could not establish any significant association between circulating autoantibody titres to MDA-LDL and coronary atherosclerosis. Therefore, the diagnostic value of autoantibodies to oxidised LDL remains unclear.

Authors+Show Affiliations

School of Biology and Biochemistry, Queen's University, Belfast, BT9 7BL, Northern Ireland, UK. a.mcdowell@qub.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12542895

Citation

McDowell, A, et al. "Autoantibodies to Malondialdehyde-modified Low-density Lipoprotein in Patients With Angiographically Confirmed Coronary Artery Disease." The Journal of Pharmacy and Pharmacology, vol. 54, no. 12, 2002, pp. 1651-7.
McDowell A, Young IS, Wisdom GB. Autoantibodies to malondialdehyde-modified low-density lipoprotein in patients with angiographically confirmed coronary artery disease. J Pharm Pharmacol. 2002;54(12):1651-7.
McDowell, A., Young, I. S., & Wisdom, G. B. (2002). Autoantibodies to malondialdehyde-modified low-density lipoprotein in patients with angiographically confirmed coronary artery disease. The Journal of Pharmacy and Pharmacology, 54(12), 1651-7.
McDowell A, Young IS, Wisdom GB. Autoantibodies to Malondialdehyde-modified Low-density Lipoprotein in Patients With Angiographically Confirmed Coronary Artery Disease. J Pharm Pharmacol. 2002;54(12):1651-7. PubMed PMID: 12542895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoantibodies to malondialdehyde-modified low-density lipoprotein in patients with angiographically confirmed coronary artery disease. AU - McDowell,A, AU - Young,I S, AU - Wisdom,G B, PY - 2003/1/25/pubmed PY - 2003/6/17/medline PY - 2003/1/25/entrez SP - 1651 EP - 7 JF - The Journal of pharmacy and pharmacology JO - J. Pharm. Pharmacol. VL - 54 IS - 12 N2 - Oxidised low-density lipoprotein (LDL) has physicochemical properties that are pivotal in atherosclerotic plaque formation. As a consequence, antioxidant regimens may prove an important therapy in the prevention and treatment of cardiovascular disease. Since oxidised LDL is immunogenic, the aims of our study were to measure serum IgG titres to malondialdehyde-modified LDL (MDA-LDL) in patients with coronary artery disease (CAD) and control subjects and assess their potential as a clinical marker for coronary atherosclerosis and, consequently, antioxidant intervention. Serum IgG titres to MDA-LDL were measured in patients with angiographically confirmed CAD (n = 40) and aged-matched controls (n = 40) by enzyme-linked immunosorbant assay (ELISA). Titres were calculated and expressed as both the difference and the ratio of blanked absorbance units (AU) for IgG binding to MDA-LDL and native LDL. For the control population, median IgG titres were 0.26 AU (interquartile range (IQR) 0.20-0.46 AU) and 5.34 (IQR 3.40-8.58), respectively, while the patient population had median IgG titres of 0.30 AU (IQR 0.20-0.47 AU) and 5.08 (IQR 3.30-9.66), respectively. Both sets of calculated titre values were not significantly different between the two groups (P = 0.60 and 0.82, respectively). In conclusion, this study could not establish any significant association between circulating autoantibody titres to MDA-LDL and coronary atherosclerosis. Therefore, the diagnostic value of autoantibodies to oxidised LDL remains unclear. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/12542895/Autoantibodies_to_malondialdehyde_modified_low_density_lipoprotein_in_patients_with_angiographically_confirmed_coronary_artery_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3573&date=2002&volume=54&issue=12&spage=1651 DB - PRIME DP - Unbound Medicine ER -