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Cobalamin-binding proteins in normal and cobalamin-deficient older subjects.
Ann Clin Biochem 2003; 40(Pt 1):65-9AC

Abstract

BACKGROUND

The causes of cobalamin (vitamin B(12)) deficiency in older people are only partly understood. We investigated the role of the cobalamin-binding proteins and tested the hypothesis that low saturated transcobalamin concentration is an early marker of cobalamin deficiency.

METHODS

We measured saturated (holo) and unsaturated (apo) transcobalamin and haptocorrin concentrations in healthy middle-aged volunteers, healthy older volunteers, cobalamin-deficient older volunteers and cobalamin-deficient older patients.

RESULTS

Holo and apo concentrations of transcobalamin and haptocorrin were similar in healthy middle-aged and older subjects. Holotranscobalamin concentrations were significantly decreased in cobalamin-deficient subjects but did not differ between healthy volunteers and patients. Furthermore, the relative amount of cobalamin on transcobalamin (i.e. holotranscobalamin/holotranscobalamin + holohaptocorrin) was similar in all four groups.

CONCLUSIONS

Abnormalities of the cobalamin-binding proteins are not a cause of cobalamin deficiency in the aged. Plasma holotranscobalamin concentration did not differ between stages of cobalamin deficiency in older persons. Therefore, plasma holotranscobalamin is not an early marker of cobalamin deficiency in older people and has no additional value in the diagnostic work-up of reduced plasma cobalamin concentrations in older people.

Authors+Show Affiliations

Geriatric Medicine, University Medical Centre Nijmegen, Nijmegen, The Netherlands. Dieneke.van.Asselt@znb.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12542912

Citation

van Asselt, Dieneke Z B., et al. "Cobalamin-binding Proteins in Normal and Cobalamin-deficient Older Subjects." Annals of Clinical Biochemistry, vol. 40, no. Pt 1, 2003, pp. 65-9.
van Asselt DZ, Thomas CM, Segers MF, et al. Cobalamin-binding proteins in normal and cobalamin-deficient older subjects. Ann Clin Biochem. 2003;40(Pt 1):65-9.
van Asselt, D. Z., Thomas, C. M., Segers, M. F., Blom, H. J., Wevers, R. A., & Hoefnagels, W. H. (2003). Cobalamin-binding proteins in normal and cobalamin-deficient older subjects. Annals of Clinical Biochemistry, 40(Pt 1), pp. 65-9.
van Asselt DZ, et al. Cobalamin-binding Proteins in Normal and Cobalamin-deficient Older Subjects. Ann Clin Biochem. 2003;40(Pt 1):65-9. PubMed PMID: 12542912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cobalamin-binding proteins in normal and cobalamin-deficient older subjects. AU - van Asselt,Dieneke Z B, AU - Thomas,Chris M G, AU - Segers,Martin F G, AU - Blom,Henk J, AU - Wevers,Ron A, AU - Hoefnagels,Willibrord H L, PY - 2003/1/25/pubmed PY - 2003/6/26/medline PY - 2003/1/25/entrez SP - 65 EP - 9 JF - Annals of clinical biochemistry JO - Ann. Clin. Biochem. VL - 40 IS - Pt 1 N2 - BACKGROUND: The causes of cobalamin (vitamin B(12)) deficiency in older people are only partly understood. We investigated the role of the cobalamin-binding proteins and tested the hypothesis that low saturated transcobalamin concentration is an early marker of cobalamin deficiency. METHODS: We measured saturated (holo) and unsaturated (apo) transcobalamin and haptocorrin concentrations in healthy middle-aged volunteers, healthy older volunteers, cobalamin-deficient older volunteers and cobalamin-deficient older patients. RESULTS: Holo and apo concentrations of transcobalamin and haptocorrin were similar in healthy middle-aged and older subjects. Holotranscobalamin concentrations were significantly decreased in cobalamin-deficient subjects but did not differ between healthy volunteers and patients. Furthermore, the relative amount of cobalamin on transcobalamin (i.e. holotranscobalamin/holotranscobalamin + holohaptocorrin) was similar in all four groups. CONCLUSIONS: Abnormalities of the cobalamin-binding proteins are not a cause of cobalamin deficiency in the aged. Plasma holotranscobalamin concentration did not differ between stages of cobalamin deficiency in older persons. Therefore, plasma holotranscobalamin is not an early marker of cobalamin deficiency in older people and has no additional value in the diagnostic work-up of reduced plasma cobalamin concentrations in older people. SN - 0004-5632 UR - https://www.unboundmedicine.com/medline/citation/12542912/Cobalamin_binding_proteins_in_normal_and_cobalamin_deficient_older_subjects_ L2 - http://journals.sagepub.com/doi/full/10.1258/000456303321016187?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -