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Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men.
J Urol 2003; 169(2):507-11JU

Abstract

PURPOSE

Herbal remedies high in phytoestrogens have been shown to reduce serum prostate specific antigen (PSA) and have been proposed as a treatment for prostate cancer. Soy proteins used to lower serum cholesterol are rich sources of phytoestrogens. Therefore, we assessed the effect of soy consumption on serum PSA in men who had participated in cholesterol lowering studies.

MATERIALS AND METHODS

For 3 to 4 weeks 46 healthy middle-aged men with a range of starting PSA values took soy (mean 44 gm. soy protein daily, 116 mg. isoflavones daily) or control foods, and a subgroup of men took a lower level of soy supplements for 3 months. PSA was measured at the start and end of each treatment.

RESULTS

Soy had no significant effect on serum total or free PSA, independent of PSA starting value or isoflavone intake. The lack of effect on PSA was seen, although soy intake was sufficient to reduce low-density lipoprotein cholesterol (5.8 +/- 2.2%, p = 0.012), the estimated coronary heart disease risk (6.1 +/- 2.8% for 10 years, p = 0.032) and the serum concentration of oxidized low-density lipoprotein measured as conjugated dienes (9.5 +/- 3.4%, p = 0.008) in the 3 to 4-week study. In addition, the lack of effect of soy on PSA persisted for the 3 months of the extended study.

CONCLUSIONS

At levels of soy intake which reduce low-density lipoprotein cholesterol any potential benefits of soy consumption on prostate cancer are likely to occur for reasons other than alterations in hormone activity.

Authors+Show Affiliations

Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, 61 Queen St. East, Toronto, Ontario, Canada M5C 2T2.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12544298

Citation

Jenkins, David J A., et al. "Soy Consumption and Phytoestrogens: Effect On Serum Prostate Specific Antigen when Blood Lipids and Oxidized Low-density Lipoprotein Are Reduced in Hyperlipidemic Men." The Journal of Urology, vol. 169, no. 2, 2003, pp. 507-11.
Jenkins DJ, Kendall CW, D'Costa MA, et al. Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men. J Urol. 2003;169(2):507-11.
Jenkins, D. J., Kendall, C. W., D'Costa, M. A., Jackson, C. J., Vidgen, E., Singer, W., ... Klotz, L. (2003). Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men. The Journal of Urology, 169(2), pp. 507-11.
Jenkins DJ, et al. Soy Consumption and Phytoestrogens: Effect On Serum Prostate Specific Antigen when Blood Lipids and Oxidized Low-density Lipoprotein Are Reduced in Hyperlipidemic Men. J Urol. 2003;169(2):507-11. PubMed PMID: 12544298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men. AU - Jenkins,David J A, AU - Kendall,Cyril W C, AU - D'Costa,Mario A, AU - Jackson,Chung-Ja, AU - Vidgen,Edward, AU - Singer,William, AU - Silverman,Jason A, AU - Koumbridis,George, AU - Honey,John, AU - Rao,A Venket, AU - Fleshner,Neil, AU - Klotz,Laurence, PY - 2003/1/25/pubmed PY - 2003/2/26/medline PY - 2003/1/25/entrez SP - 507 EP - 11 JF - The Journal of urology JO - J. Urol. VL - 169 IS - 2 N2 - PURPOSE: Herbal remedies high in phytoestrogens have been shown to reduce serum prostate specific antigen (PSA) and have been proposed as a treatment for prostate cancer. Soy proteins used to lower serum cholesterol are rich sources of phytoestrogens. Therefore, we assessed the effect of soy consumption on serum PSA in men who had participated in cholesterol lowering studies. MATERIALS AND METHODS: For 3 to 4 weeks 46 healthy middle-aged men with a range of starting PSA values took soy (mean 44 gm. soy protein daily, 116 mg. isoflavones daily) or control foods, and a subgroup of men took a lower level of soy supplements for 3 months. PSA was measured at the start and end of each treatment. RESULTS: Soy had no significant effect on serum total or free PSA, independent of PSA starting value or isoflavone intake. The lack of effect on PSA was seen, although soy intake was sufficient to reduce low-density lipoprotein cholesterol (5.8 +/- 2.2%, p = 0.012), the estimated coronary heart disease risk (6.1 +/- 2.8% for 10 years, p = 0.032) and the serum concentration of oxidized low-density lipoprotein measured as conjugated dienes (9.5 +/- 3.4%, p = 0.008) in the 3 to 4-week study. In addition, the lack of effect of soy on PSA persisted for the 3 months of the extended study. CONCLUSIONS: At levels of soy intake which reduce low-density lipoprotein cholesterol any potential benefits of soy consumption on prostate cancer are likely to occur for reasons other than alterations in hormone activity. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/12544298/Soy_consumption_and_phytoestrogens:_effect_on_serum_prostate_specific_antigen_when_blood_lipids_and_oxidized_low_density_lipoprotein_are_reduced_in_hyperlipidemic_men_ L2 - https://www.jurology.com/doi/full/10.1097/01.ju.0000046060.59113.57?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -