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Association of cigarette smoking with extraprostatic prostate cancer in young men.
J Urol. 2003 Feb; 169(2):512-6; discussion 516.JU

Abstract

PURPOSE

A few recent studies have revealed that cumulative or recent smoking is associated with death from prostate cancer suggesting that smoking may influence progression to more advanced disease. We evaluate the association of cigarette smoking with extraprostatic and/or Gleason sum 7 or greater prostate cancer in young men.

MATERIALS AND METHODS

The study included men who underwent radical prostatectomy before age 55 years for prostate cancer between 1992 and 1999. A survey soliciting cigarette smoking history and other exposures was mailed to 498 eligible men. The response rate was 73%. Cases were defined as men with Gleason sum 7 or greater, extraprostatic or Gleason sum 7 or greater/extraprostatic disease based on pathologic analysis. All remaining participants were considered noncases for each case definition. We used logistic regression modeling to estimate the odds ratio (OR) for Gleason sum 7 or greater, extraprostatic and Gleason sum 7 or greater/extraprostatic disease with cigarette smoking.

RESULTS

Of the 352 respondents with a cigarette smoking history 5.4% were current smokers and 44.6% were former smokers at the time of surgery. The odds ratios of extraprostatic and Gleason sum 7 or greater/extraprostatic disease were 3.85 (95% CI 1.44-10.33) and 3.17 (95% CI = 1.13-8.85), respectively, for current smokers compared to men who never smoked. Evidence of an association of smoking with Gleason sum 7 or greater disease was limited. Risk of extraprostatic (p = 0.005) and Gleason sum 7 or greater/extraprostatic (p = 0.003) disease increased with increasing cumulative pack-years smoked. Higher cumulative smoking in the 10 years before surgery was associated with an increased risk of extraprostatic (p = 0.004) and Gleason sum 7 or greater/extraprostatic (p = 0.005) disease.

CONCLUSIONS

Cigarette smoking may influence the risk of extraprostatic prostate cancer in young men.

Authors+Show Affiliations

The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, the Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12544299

Citation

Roberts, William W., et al. "Association of Cigarette Smoking With Extraprostatic Prostate Cancer in Young Men." The Journal of Urology, vol. 169, no. 2, 2003, pp. 512-6; discussion 516.
Roberts WW, Platz EA, Walsh PC. Association of cigarette smoking with extraprostatic prostate cancer in young men. J Urol. 2003;169(2):512-6; discussion 516.
Roberts, W. W., Platz, E. A., & Walsh, P. C. (2003). Association of cigarette smoking with extraprostatic prostate cancer in young men. The Journal of Urology, 169(2), 512-6; discussion 516.
Roberts WW, Platz EA, Walsh PC. Association of Cigarette Smoking With Extraprostatic Prostate Cancer in Young Men. J Urol. 2003;169(2):512-6; discussion 516. PubMed PMID: 12544299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of cigarette smoking with extraprostatic prostate cancer in young men. AU - Roberts,William W, AU - Platz,Elizabeth A, AU - Walsh,Patrick C, PY - 2003/1/25/pubmed PY - 2003/2/26/medline PY - 2003/1/25/entrez SP - 512-6; discussion 516 JF - The Journal of urology JO - J Urol VL - 169 IS - 2 N2 - PURPOSE: A few recent studies have revealed that cumulative or recent smoking is associated with death from prostate cancer suggesting that smoking may influence progression to more advanced disease. We evaluate the association of cigarette smoking with extraprostatic and/or Gleason sum 7 or greater prostate cancer in young men. MATERIALS AND METHODS: The study included men who underwent radical prostatectomy before age 55 years for prostate cancer between 1992 and 1999. A survey soliciting cigarette smoking history and other exposures was mailed to 498 eligible men. The response rate was 73%. Cases were defined as men with Gleason sum 7 or greater, extraprostatic or Gleason sum 7 or greater/extraprostatic disease based on pathologic analysis. All remaining participants were considered noncases for each case definition. We used logistic regression modeling to estimate the odds ratio (OR) for Gleason sum 7 or greater, extraprostatic and Gleason sum 7 or greater/extraprostatic disease with cigarette smoking. RESULTS: Of the 352 respondents with a cigarette smoking history 5.4% were current smokers and 44.6% were former smokers at the time of surgery. The odds ratios of extraprostatic and Gleason sum 7 or greater/extraprostatic disease were 3.85 (95% CI 1.44-10.33) and 3.17 (95% CI = 1.13-8.85), respectively, for current smokers compared to men who never smoked. Evidence of an association of smoking with Gleason sum 7 or greater disease was limited. Risk of extraprostatic (p = 0.005) and Gleason sum 7 or greater/extraprostatic (p = 0.003) disease increased with increasing cumulative pack-years smoked. Higher cumulative smoking in the 10 years before surgery was associated with an increased risk of extraprostatic (p = 0.004) and Gleason sum 7 or greater/extraprostatic (p = 0.005) disease. CONCLUSIONS: Cigarette smoking may influence the risk of extraprostatic prostate cancer in young men. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/12544299/Association_of_cigarette_smoking_with_extraprostatic_prostate_cancer_in_young_men_ L2 - https://www.jurology.com/doi/10.1097/01.ju.0000046160.80804.7f?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -