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Testis histopathology in boys with cryptorchidism correlates with future fertility potential.
J Urol. 2003 Feb; 169(2):659-62.JU

Abstract

PURPOSE

We studied the ability of testis biopsy to predict eventual fertility potential.

MATERIALS AND METHODS

A total of 25 patients with unilateral undescended testis and 11 with bilateral undescended testes who previously underwent orchiopexy at a median age of 9 years were followed until after age 18 years. Semen analysis, testicular volume, follicle-stimulating hormone, luteinizing hormone, testosterone and inhibin B were compared to previously obtained biopsies of each testis. Biopsies were graded as mild, moderate or severe histology based on published data for normal and undescended testis histology.

RESULTS

Patients with unilateral undescended testis and moderate histology were more likely to have a sperm density of greater than 20 million per cc than those with severe histology (p = 0.006), although no difference in hormonal parameters was noted. Patients with bilateral undescended testes and moderate histology were more likely to have normal follicle-stimulating hormone and inhibin B than those with severe histology (p = 0.05 and 0.002, respectively), although no difference in semen analysis was observed. Overall 7 of the 9 patients with bilateral undescended testes had less than 20 million sperm per cc.

CONCLUSIONS

Testis biopsy provides useful prognostic information about semen analysis in patients with unilateral undescended testis. In the 9 patients with bilateral undescended testes testis biopsy divided them into normal and abnormal groups in terms of hormonal parameters. Testis biopsy was not able to provide additional prognostic information on semen analysis in patients with bilateral undescended testes since they were uniformly poor.

Authors+Show Affiliations

Divisions of Pediatric Urology, Pathology and Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12544338

Citation

Rusnack, Susan L., et al. "Testis Histopathology in Boys With Cryptorchidism Correlates With Future Fertility Potential." The Journal of Urology, vol. 169, no. 2, 2003, pp. 659-62.
Rusnack SL, Wu HY, Huff DS, et al. Testis histopathology in boys with cryptorchidism correlates with future fertility potential. J Urol. 2003;169(2):659-62.
Rusnack, S. L., Wu, H. Y., Huff, D. S., Snyder, H. M., Carr, M. C., Bellah, R. D., Zderic, S. A., & Canning, D. A. (2003). Testis histopathology in boys with cryptorchidism correlates with future fertility potential. The Journal of Urology, 169(2), 659-62.
Rusnack SL, et al. Testis Histopathology in Boys With Cryptorchidism Correlates With Future Fertility Potential. J Urol. 2003;169(2):659-62. PubMed PMID: 12544338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Testis histopathology in boys with cryptorchidism correlates with future fertility potential. AU - Rusnack,Susan L, AU - Wu,Hsi-Yang, AU - Huff,Dale S, AU - Snyder,Howard M,3rd AU - Carr,Michael C, AU - Bellah,Richard D, AU - Zderic,Stephen A, AU - Canning,Douglas A, PY - 2003/1/25/pubmed PY - 2003/2/26/medline PY - 2003/1/25/entrez SP - 659 EP - 62 JF - The Journal of urology JO - J. Urol. VL - 169 IS - 2 N2 - PURPOSE: We studied the ability of testis biopsy to predict eventual fertility potential. MATERIALS AND METHODS: A total of 25 patients with unilateral undescended testis and 11 with bilateral undescended testes who previously underwent orchiopexy at a median age of 9 years were followed until after age 18 years. Semen analysis, testicular volume, follicle-stimulating hormone, luteinizing hormone, testosterone and inhibin B were compared to previously obtained biopsies of each testis. Biopsies were graded as mild, moderate or severe histology based on published data for normal and undescended testis histology. RESULTS: Patients with unilateral undescended testis and moderate histology were more likely to have a sperm density of greater than 20 million per cc than those with severe histology (p = 0.006), although no difference in hormonal parameters was noted. Patients with bilateral undescended testes and moderate histology were more likely to have normal follicle-stimulating hormone and inhibin B than those with severe histology (p = 0.05 and 0.002, respectively), although no difference in semen analysis was observed. Overall 7 of the 9 patients with bilateral undescended testes had less than 20 million sperm per cc. CONCLUSIONS: Testis biopsy provides useful prognostic information about semen analysis in patients with unilateral undescended testis. In the 9 patients with bilateral undescended testes testis biopsy divided them into normal and abnormal groups in terms of hormonal parameters. Testis biopsy was not able to provide additional prognostic information on semen analysis in patients with bilateral undescended testes since they were uniformly poor. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/12544338/Testis_histopathology_in_boys_with_cryptorchidism_correlates_with_future_fertility_potential_ L2 - https://www.jurology.com/doi/full/10.1097/01.ju.0000047501.25854.f3?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -