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Reference range for gastrointestinal oxalate absorption measured with a standardized [13C2]oxalate absorption test.
J Urol 2003; 169(2):687-90JU

Abstract

PURPOSE

Hyperoxaluria is a prominent risk factor for calcium oxalate urinary stones. Oxalate in urine is synthesized in the body or absorbed from food in the gastrointestinal tract. The amount of oxalate absorbed by patients with calcium oxalate stones may vary from a few percent to 50% of the dietary intake. Reference values for oxalate absorption measured under a standardized diet have never been attained in sufficient numbers from healthy individuals. Therefore, to our knowledge we collected for the first time the values required to interpret test results in patients with recurrent urinary stones.

MATERIALS AND METHODS

A total of 120 healthy volunteers, including 60 females and 60 males, received an identical standard diet on 2 consecutive days. On the morning of day 2 a capsule containing 0.37 mmol. sodium [13C2]oxalate (not radioactive) was ingested with water. Urinary oxalate was measured by gas chromatography-mass spectrometry. Absorption at a fixed 800 mg. daily Ca input is expressed as a percent of the labeled oxalate dose.

RESULTS

For the standardized [13C2]oxalate absorption test the reference range in 95% of the 120 volunteers was 2.2% to 18.5% (mean +/- SD 7.9% +/- 4.0%). The repeatability of the standardized test was determined in 26 of the 120 volunteers by repeating the test twice. The mean intra-individual SD was 3.39% +/- 1.68%.

CONCLUSIONS

We assessed reference values of intestinal oxalate absorption using a standardized diet. Interindividual and intra-individual variance was high.

Authors+Show Affiliations

Departments of Internal Medicine I and Urology (Division of Experimental Urology), University of Bonn, Bonn, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12544343

Citation

von Unruh, Gerd E., et al. "Reference Range for Gastrointestinal Oxalate Absorption Measured With a Standardized [13C2]oxalate Absorption Test." The Journal of Urology, vol. 169, no. 2, 2003, pp. 687-90.
von Unruh GE, Voss S, Sauerbruch T, et al. Reference range for gastrointestinal oxalate absorption measured with a standardized [13C2]oxalate absorption test. J Urol. 2003;169(2):687-90.
von Unruh, G. E., Voss, S., Sauerbruch, T., & Hesse, A. (2003). Reference range for gastrointestinal oxalate absorption measured with a standardized [13C2]oxalate absorption test. The Journal of Urology, 169(2), pp. 687-90.
von Unruh GE, et al. Reference Range for Gastrointestinal Oxalate Absorption Measured With a Standardized [13C2]oxalate Absorption Test. J Urol. 2003;169(2):687-90. PubMed PMID: 12544343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reference range for gastrointestinal oxalate absorption measured with a standardized [13C2]oxalate absorption test. AU - von Unruh,Gerd E, AU - Voss,Susanne, AU - Sauerbruch,Tilman, AU - Hesse,Albrecht, PY - 2003/1/25/pubmed PY - 2003/2/26/medline PY - 2003/1/25/entrez SP - 687 EP - 90 JF - The Journal of urology JO - J. Urol. VL - 169 IS - 2 N2 - PURPOSE: Hyperoxaluria is a prominent risk factor for calcium oxalate urinary stones. Oxalate in urine is synthesized in the body or absorbed from food in the gastrointestinal tract. The amount of oxalate absorbed by patients with calcium oxalate stones may vary from a few percent to 50% of the dietary intake. Reference values for oxalate absorption measured under a standardized diet have never been attained in sufficient numbers from healthy individuals. Therefore, to our knowledge we collected for the first time the values required to interpret test results in patients with recurrent urinary stones. MATERIALS AND METHODS: A total of 120 healthy volunteers, including 60 females and 60 males, received an identical standard diet on 2 consecutive days. On the morning of day 2 a capsule containing 0.37 mmol. sodium [13C2]oxalate (not radioactive) was ingested with water. Urinary oxalate was measured by gas chromatography-mass spectrometry. Absorption at a fixed 800 mg. daily Ca input is expressed as a percent of the labeled oxalate dose. RESULTS: For the standardized [13C2]oxalate absorption test the reference range in 95% of the 120 volunteers was 2.2% to 18.5% (mean +/- SD 7.9% +/- 4.0%). The repeatability of the standardized test was determined in 26 of the 120 volunteers by repeating the test twice. The mean intra-individual SD was 3.39% +/- 1.68%. CONCLUSIONS: We assessed reference values of intestinal oxalate absorption using a standardized diet. Interindividual and intra-individual variance was high. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/12544343/Reference_range_for_gastrointestinal_oxalate_absorption_measured_with_a_standardized_[13C2]oxalate_absorption_test_ L2 - https://www.jurology.com/doi/full/10.1097/01.ju.0000051637.63068.92?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -