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Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children.
Pediatr Infect Dis J 2003; 22(1):28-34PI

Abstract

BACKGROUND

The cold-adapted, trivalent influenza vaccine (CAIV-T) may become an option for annual vaccination. However, there is little information regarding the immune response to repeated immunization with CAIV-T.

OBJECTIVE

To determine the antibody response to repeated immunization with CAIV-T and to compare this with the response after the first CAIV-T immunization.

DESIGN AND METHODS

Healthy children were offered CAIV-T immunization for 4 consecutive years, and blood samples were taken from a subset in Years 1, 2 and 4. In Year 4, 156 similarly aged children who had not received influenza vaccine previously were immunized with the same CAIV-T.

RESULTS

The H3N2 and B components of the CAIV-T induced high antibody titers in Year 1 that were maintained during 4 years. The H1N1 titers were lower than the H3N2 or B titers. Comparison of the group immunized for 4 consecutive years with the group immunized for the first time revealed the following: (1) before immunization yearly immunized subjects were more likely to be seropositive to each of the three vaccine strains than those immunized for the first time (P < 0.05 for each); (2) after immunization the percentage of seropositive subjects to each of the strains was similar; (3) after immunization titers were higher in the subjects immunized for the first time than those immunized yearly (P < 0.05 for H3N2 and B).

CONCLUSION

Yearly vaccination with CAIV-T induced high antibody titers, especially to the H3N2 and B strains in the vaccines. The titers in those immunized with CAIV-T for the first time were higher than in those immunized for 4 consecutive years.

Authors+Show Affiliations

Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, OH, USA. david.bernstein@chmcc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12544405

Citation

Bernstein, David I., et al. "Effect of Yearly Vaccinations With Live, Attenuated, Cold-adapted, Trivalent, Intranasal Influenza Vaccines On Antibody Responses in Children." The Pediatric Infectious Disease Journal, vol. 22, no. 1, 2003, pp. 28-34.
Bernstein DI, Yan L, Treanor J, et al. Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children. Pediatr Infect Dis J. 2003;22(1):28-34.
Bernstein, D. I., Yan, L., Treanor, J., Mendelman, P. M., & Belshe, R. (2003). Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children. The Pediatric Infectious Disease Journal, 22(1), pp. 28-34.
Bernstein DI, et al. Effect of Yearly Vaccinations With Live, Attenuated, Cold-adapted, Trivalent, Intranasal Influenza Vaccines On Antibody Responses in Children. Pediatr Infect Dis J. 2003;22(1):28-34. PubMed PMID: 12544405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children. AU - Bernstein,David I, AU - Yan,Lihan, AU - Treanor,John, AU - Mendelman,Paul M, AU - Belshe,Robert, AU - ,, PY - 2003/1/25/pubmed PY - 2003/3/14/medline PY - 2003/1/25/entrez SP - 28 EP - 34 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 22 IS - 1 N2 - BACKGROUND: The cold-adapted, trivalent influenza vaccine (CAIV-T) may become an option for annual vaccination. However, there is little information regarding the immune response to repeated immunization with CAIV-T. OBJECTIVE: To determine the antibody response to repeated immunization with CAIV-T and to compare this with the response after the first CAIV-T immunization. DESIGN AND METHODS: Healthy children were offered CAIV-T immunization for 4 consecutive years, and blood samples were taken from a subset in Years 1, 2 and 4. In Year 4, 156 similarly aged children who had not received influenza vaccine previously were immunized with the same CAIV-T. RESULTS: The H3N2 and B components of the CAIV-T induced high antibody titers in Year 1 that were maintained during 4 years. The H1N1 titers were lower than the H3N2 or B titers. Comparison of the group immunized for 4 consecutive years with the group immunized for the first time revealed the following: (1) before immunization yearly immunized subjects were more likely to be seropositive to each of the three vaccine strains than those immunized for the first time (P < 0.05 for each); (2) after immunization the percentage of seropositive subjects to each of the strains was similar; (3) after immunization titers were higher in the subjects immunized for the first time than those immunized yearly (P < 0.05 for H3N2 and B). CONCLUSION: Yearly vaccination with CAIV-T induced high antibody titers, especially to the H3N2 and B strains in the vaccines. The titers in those immunized with CAIV-T for the first time were higher than in those immunized for 4 consecutive years. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/12544405/Effect_of_yearly_vaccinations_with_live_attenuated_cold_adapted_trivalent_intranasal_influenza_vaccines_on_antibody_responses_in_children_ L2 - http://Insights.ovid.com/pubmed?pmid=12544405 DB - PRIME DP - Unbound Medicine ER -