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Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7.
Ann Allergy Asthma Immunol 2003; 90(1):41-4AA

Abstract

BACKGROUND

Several studies have suggested that exposure to house-dust mite (HDM) allergen in infancy increases the risk of developing asthma.

OBJECTIVE

To determine whether exposure to higher levels of dust mite in infants increased the risk of developing bronchial hyperresponsiveness (BHR) or physician-diagnosed asthma by age 6 to 7 years.

METHODS

A health maintenance organization-based cohort of 97 middle class suburban children born from 1987 to 1989 with a high cord blood immunoglobulin E, defined as > or = 0.56 IU/mL, was followed as a part of the Childhood Allergy Study. During the first 2 years of life, monthly bedroom dust samples were collected and analyzed for Der f 1 and Der p 1. Between 6 and 7 years of age, 64 of the original cohort answered a questionnaire used to determine the presence of physician-diagnosed asthma, underwent clinical examination, skin prick testing, and methacholine inhalation challenge. Mann-Whitney tests were used to compare Der f 1 and Der p 1 levels in homes of children with and without BHR, and those with and without physician-diagnosed asthma.

RESULTS

In all, 1,421 dust samples were collected and assayed. No significant differences were seen in either the mean, maximum, or minimum dust mite allergen levels in homes of children with versus without BHR, or children with versus without asthma. However, sensitization to HDM was associated with physician-diagnosed asthma (P < 0.05).

CONCLUSIONS

When compared with other studies, we were able to more accurately estimate the level of dust mite allergen exposure through repeated sampling over a relatively long period, incorporating seasonal variations. Although HDM sensitization and asthma were concurrently related, we were unable to find any relationship between level of HDM allergen exposure in children's bedrooms in early childhood and development of BHR or physician-diagnosed asthma by age 6 to 7 years.

Authors+Show Affiliations

Henry Ford Health System, Division of Allergy, Detroit, Michigan, USA. pmcmd@att.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12546336

Citation

Carter, Paul M., et al. "Relationship of House-dust Mite Allergen Exposure in Children's Bedrooms in Infancy to Bronchial Hyperresponsiveness and Asthma Diagnosis By Age 6 to 7." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 90, no. 1, 2003, pp. 41-4.
Carter PM, Peterson EL, Ownby DR, et al. Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7. Ann Allergy Asthma Immunol. 2003;90(1):41-4.
Carter, P. M., Peterson, E. L., Ownby, D. R., Zoratti, E. M., & Johnson, C. C. (2003). Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 90(1), pp. 41-4.
Carter PM, et al. Relationship of House-dust Mite Allergen Exposure in Children's Bedrooms in Infancy to Bronchial Hyperresponsiveness and Asthma Diagnosis By Age 6 to 7. Ann Allergy Asthma Immunol. 2003;90(1):41-4. PubMed PMID: 12546336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7. AU - Carter,Paul M, AU - Peterson,Edward L, AU - Ownby,Dennis R, AU - Zoratti,Edward M, AU - Johnson,Christine C, PY - 2003/1/28/pubmed PY - 2003/2/22/medline PY - 2003/1/28/entrez SP - 41 EP - 4 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 90 IS - 1 N2 - BACKGROUND: Several studies have suggested that exposure to house-dust mite (HDM) allergen in infancy increases the risk of developing asthma. OBJECTIVE: To determine whether exposure to higher levels of dust mite in infants increased the risk of developing bronchial hyperresponsiveness (BHR) or physician-diagnosed asthma by age 6 to 7 years. METHODS: A health maintenance organization-based cohort of 97 middle class suburban children born from 1987 to 1989 with a high cord blood immunoglobulin E, defined as > or = 0.56 IU/mL, was followed as a part of the Childhood Allergy Study. During the first 2 years of life, monthly bedroom dust samples were collected and analyzed for Der f 1 and Der p 1. Between 6 and 7 years of age, 64 of the original cohort answered a questionnaire used to determine the presence of physician-diagnosed asthma, underwent clinical examination, skin prick testing, and methacholine inhalation challenge. Mann-Whitney tests were used to compare Der f 1 and Der p 1 levels in homes of children with and without BHR, and those with and without physician-diagnosed asthma. RESULTS: In all, 1,421 dust samples were collected and assayed. No significant differences were seen in either the mean, maximum, or minimum dust mite allergen levels in homes of children with versus without BHR, or children with versus without asthma. However, sensitization to HDM was associated with physician-diagnosed asthma (P < 0.05). CONCLUSIONS: When compared with other studies, we were able to more accurately estimate the level of dust mite allergen exposure through repeated sampling over a relatively long period, incorporating seasonal variations. Although HDM sensitization and asthma were concurrently related, we were unable to find any relationship between level of HDM allergen exposure in children's bedrooms in early childhood and development of BHR or physician-diagnosed asthma by age 6 to 7 years. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/12546336/Relationship_of_house_dust_mite_allergen_exposure_in_children's_bedrooms_in_infancy_to_bronchial_hyperresponsiveness_and_asthma_diagnosis_by_age_6_to_7_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)63612-5 DB - PRIME DP - Unbound Medicine ER -